FERNANDA MARCIANO CONSOLIM COLOMBO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
- Posicionamento Brasileiro sobre Hipertensao Arterial Resistente - 2020 (vol 114, pg 576, 2020)(2020) YUGAR-TOLEDO, Juan Carlos; MORENO JUNIOR, Heitor; GUS, Miguel; ROSITO, Guido Bernardo Aranha; SCALA, Luiz Cesar Nazario; MUXFELDT, Elizabeth Silaid; ALESSI, Alexandre; BRANDAO, Andrea Araujo; MOREIRA FILHO, Osni; FEITOSA, Audes Diogenes de Magalhaes; PASSARELLI JUNIOR, Oswaldo; SOUZA, Dilma do Socorro Moraes de; AMODEO, Celso; BARROSO, Weimar Kunz Sebba; GOMES, Marco Antonio Mota; PAIVA, Annelise Machado Gomes de; BARBOSA, Eduardo Costa Duarte; MIRANDA, Roberto Dischinger; VILELA-MARTIN, Jose Fernando; NADRUZ JUNIOR, Wilson; RODRIGUES, Cibele Isaac Saad; DRAGER, Luciano Ferreira; BORTOLOTTO, Luiz Aparecido; CONSOLIM-COLOMBO, Fernanda Marciano; SOUSA, Marcio Goncalves de; BORELLI, Flavio Antonio de Oliveira; KAISER, Sergio Emanuel; SALLES, Gil Fernando; AZEVEDO, Maria de Fatima de; MAGALHAES, Lucelia Batista Neves Cunha; POVOA, Rui Manoel dos Santos; MALACHIAS, Marcus Vinicius Bolivar; NOGUEIRA, Armando da Rocha; JARDIM, Paulo Cesar Brandao Veiga; JARDIM, Thiago de Souza Veiga
- Does Obstructive Sleep Apnea Influence Blood Pressure and Arterial Stiffness in Response to Antihypertensive Treatment?(2018) FATURETO-BORGES, Fernanda; JENNER, Raimundo; COSTA-HONG, Valeria; LOPES, Heno F.; TEIXEIRA, Sandra H.; MARUM, Elias; GIORGI, Dante A. M.; CONSOLIM-COLOMBO, Fernanda M.; BORTOLOTTO, Luiz A.; LORENZI-FILHO, Geraldo; KRIEGER, Eduardo M.; DRAGER, Luciano F.Untreated obstructive sleep apnea (OSA) is common in patients with hypertension and may impair blood pressure (BP) and target-organ damage responses to antihypertensive therapy. In this study, we recruited hypertensive patients who underwent treatment with a 30-day regimen of hydrochlorothiazide 25 mg plus enalapril (20 mg BID) or losartan (50 mg BID) and were assessed with a baseline clinical evaluation, polysomnography, 24-hour ambulatory BP monitoring, and carotid-femoral pulse wave velocity. All the examinations except for polysomnography were repeated at 6 and 18 months of follow-up. We studied 94 hypertensive patients (mean age, 55 +/- 9 years). The frequency of OSA was 55%. Compared with baseline, we did not observe significant differences between groups in 24-hour BP, daytime systolic and diastolic BPs, or night-time systolic BP at 6 and 18 months. The BP control rate at 24 hours (<130/80 mmHg) was similar between the groups (baseline, 42.3% versus 45.2%; 6 months, 46.9% versus 57.5%; 18 months, 66.7% versus 61.5%). However, patients with OSA had higher night-time diastolic BP decrease than did the non-OSA group (6 months, -4.9 +/- 11.8 versus -0.3 +/- 10.3 mmHg; 18 months, -6.7 +/- 11.1 versus -1.2 +/- 10.6 mmHg; P=0.027). There were no differences in the number and class of antihypertensive medications prescribed during follow-up. In terms of arterial stiffness, patients with OSA had higher pulse wave velocity than did patients without OSA at baseline (10.3 +/- 1.9 versus 9.2 +/- 1.7 m/s; P=0.024), but both groups had similar decreases in pulse wave velocity during follow-up. In conclusion, with combined antihypertensive treatment aimed at controlling BP, hypertensive patients with OSA had similar 24-hour BP and arterial stiffness to those without OSA.
- Intra-individual Variability of Serum Aldosterone and Implications for Primary Aldosteronism Screening(2023) MACIEL, Ana Alice W.; FREITAS, Thais C.; FAGUNDES, Gustavo F. C.; PETENUCI, Janaina; VILELA, Leticia A. P.; BRITO, Luciana P.; GOLDBAUM, Tatiana S.; ZERBINI, Maria Claudia N.; LEDESMA, Felipe L.; TANNO, Fabio Y.; SROUGI, Victor; CHAMBO, Jose L.; PEREIRA, Maria Adelaide A.; COELHO, Fernando M. A.; CAVALCANTE, Aline C. B. S.; CARNEVALE, Francisco C.; PILAN, Bruna; PIO-ABREU, Andrea; V, Joao Silveira; CONSOLIM-COLOMBO, Fernanda M.; BORTOLOTTO, Luiz A.; LATRONICO, Ana Claudia; V, Maria Candida B. Fragoso; DRAGER, Luciano F.; MENDONCA, Berenice B.; ALMEIDA, Madson Q.Context Primary aldosteronism (PA) screening relies on an elevated aldosterone to renin ratio with a minimum aldosterone level, which varies from 10 to 15 ng/dL (277-415.5 pmol/L) using immunoassay. Objective To evaluate intra-individual coefficient of variation (CV) of aldosterone and aldosterone to direct renin concentration ratio (A/DRC) and its impact on PA screening. Methods A total of 671 aldosterone and DRC measurements were performed by the same chemiluminescence assays in a large cohort of 216 patients with confirmed PA and at least 2 screenings. Results The median intra-individual CV of aldosterone and A/DRC was 26.8% and 26.7%. Almost 40% of the patients had at least one aldosterone level <15 ng/dL, 19.9% had at least 2 aldosterone levels <15 ng/dL, and 16.2% had mean aldosterone levels <15 ng/dL. A lower cutoff of 10 ng/dL was associated with false negative rates for PA screening of 14.3% for a single aldosterone measurement, 4.6% for 2 aldosterone measurements, and only 2.3% for mean aldosterone levels. Considering the minimum aldosterone, true positive rate of aldosterone thresholds was 85.7% for 10 ng/dL and 61.6% for 15 ng/dL. An A/DRC >2 ng/dL/mu IU/mL had a true positive rate for PA diagnosis of 94.4% and 98.4% when based on 1 or 2 assessments, respectively. CV of aldosterone and A/DRC were not affected by sex, use of interfering antihypertensive medications, PA lateralization, hypokalemia, age, and number of hormone measurements. Conclusion Aldosterone concentrations had a high CV in PA patients, which results in an elevated rate of false negatives in a single screening for PA. Therefore, PA screening should be based on at least 2 screenings with concomitant aldosterone and renin measurements.
- Intra-individual Variability of Serum Aldosterone and Implications for Primary Aldosteronism Screening (Nov, dgac679, 2022)(2023) MACHEI, A. A. W.; FREITAS, T. C.; FAGUNDES, G. F. C.; PETENUCI, J.; VILELA, L. A. P.; BRITO, L. P.; GOLDBAUM, T. S.; ZERBINI, M. C. N.; LEDESMA, F. L.; YANNO, F. Y.; SROUGI, V; CHAMBO, J. L.; PEREIRA, M. A. A.; COELHO, F. M. A.; CAVALCANTE, A. C. B. S.; CARNEVALE, F. C.; PILAN, B.; PIO-ABREU, A.; V, J. Silveira; CONSOLIM-COLOMBO, F. M.; BORTOLOTTO, L. A.; LATRONICO, A. C.; V, M. C. B. Fragoso; DRAGER, L. F.; MENDONCA, B. B.; ALMEIDA, M. Q.
- Brazilian Position Statement on Resistant Hypertension-2020(2020) YUGAR-TOLEDO, Juan Carlos; MORENO JUNIOR, Heitor; GUS, Miguel; ROSITO, Guido Bernardo Aranha; SCALA, Luiz Cesar Nazario; MUXFELDT, Elizabeth Silaid; ALESSI, Alexandre; BRANDAO, Andrea Araujo; MOREIRA FILHO, Osni; FEITOSA, Audes Diogenes de Magalhaes; PASSARELLI JUNIOR, Oswaldo; SOUZA, Dilma do Socorro Moraes de; AMODEO, Celso; BARROSO, Weimar Kunz Sebba; GOMES, Marco Antonio Mota; PAIVA, Annelise Machado Gomes de; BARBOSA, Eduardo Costa Duarte; MIRANDA, Roberto Dischinger; VILELA-MARTIN, Jose Fernando; NADRUZ JUNIOR, Wilson; RODRIGUES, Cibele Isaac Saad; DRAGER, Luciano Ferreira; BORTOLOTTO, Luiz Aparecido; CONSOLIM-COLOMBO, Fernanda Marciano; SOUSA, Marcio Goncalves de; BORELLI, Flavio Antonio de Oliveira; KAISER, Sergio Emanuel; SALLES, Gil Fernando; AZEVEDO, Maria de Fatima de; MAGALHAES, Lucelia Batista Neves Cunha; POVOA, Rui Manoel dos Santos; MALACHIAS, Marcus Vinicius Bolivar; NOGUEIRA, Armando da Rocha; JARDIM, Paulo Cesar Brandao Veiga; JARDIM, Thiago de Souza Veiga
conferenceObject LARGE ARTERIES IMPAIRMENT ARE CORRELATED TO AGEING AND DIABETES IN PATIENTS WITH STAGE 3 HYPERTENSION(2015) BORTOLOTTO, L.; SOUZA, M. G.; HONG, V. C.; GIORGI, D. M. A.; LOPES, H. F.; DRAGER, L. F.; CONSOLIM-COLOMBO, F. M.; KRIEGER, E. M.article 7TH BRAZILIAN GUIDELINE OF ARTERIAL HYPERTENSION(2016) MALACHIAS, Marcus Vinicius Bolivar; SOUZA, Weimar Kunz Sebba Barroso de; PLAVNIK, Frida Liane; RODRIGUES, Cibele Isaac Saad; BRANDAO, Andrea Araujo; NEVES, Mario Fritsch Toros; BORTOLOTTO, Luiz Aparecido; FRANCO, Roberto Jorge da Silva; FIGUEIREDO, Carlos Eduardo Poli de; JARDIM, Paulo Cesar Brandao Veiga; AMODEO, Celso; BARBOSA, Eduardo Costa Duarte; KOCH, Vera; GOMES, Marco Antonio Mota; PAULA, Rogerio Baumgratz de; PAVOA, Rui Manuel dos Santos; COLOMBO, Fernanda Consolim; FERREIRA FILHO, Sebastiao; MIRANDA, Roberto Dischinger; MACHADO, Carlos Alberto; NOBRE, Fernando; NOGUEIRA, Armando da Rocha; MION JUNIOR, Decio; KAISER, Sergio; FORJAZ, Claudia Lucia de Moraes; ALMEIDA, Fernando Antonio; MARTIM, Jose Fernando Vilela; SASS, Nelson; DRAGER, Luciano Ferreira; MUXFELDT, Elizabeth; BODANESE, Luiz Carlos; FEITOSA, Audes Diogenes; MALTA, Deborah; FUCHS, Sandra; MAGALHAES, Maria Eliane; OIGMAN, Wille; MOREIRA FILHO, Osni; PIERIN, Angela Maria Geraldo; FEITOSA, Gilson Soares; BORTOLOTTO, Maria Rita de Figueiredo Lemos; MAGALHAES, Lucelia Batista Neves Cunha; SILVA, Ana Cristina Simoes e; RIBEIRO, Jose Marcio; BORELLI, Flavio Antonio de Oliveira; GUS, Miguel; PASSARELLI JUNIOR, Oswaldo; TOLEDO, Juan Yugar; SALLES, Gil Fernando; MARTINS, Luis Cuadrado; JARDIM, Thiago de Souza Veiga; GUIMARAES, Isabel Cristina Britto; ANTONELLO, Ivan Carlos; LIMA JUNIOR, Emilton; MATSUDO, Victor; SILVA, Giovanio Vieira da; COSTA, Lilian Soares da; ALESSI, Alexandre; SCALA, Luiz Cezar Nazario; COELHO, Eduardo Barbosa; SOUZA, Dilma de; LOPES, Heno Ferreira; GOWDAK, Marcia Maria Godoy; CORDEIRO JUNIOR, Antonio Carlos; TORLONI, Maria Regina; KLEIN, Marcia Regina Simas Torres; NOGUEIRA, Paulo Koch; LOTAIF, Leda Aparecida Daud; ROSITO, Guido Bernardo Aranha; MORENO JUNIOR, HeitorconferenceObject ARTERIAL STIFFNESS IN PATIENTS WITH STAGE 3 HYPERTENSION IS CORRELATED TO INFLAMMATION AND NOCTURNAL BLOOD PRESSURE(2015) BORTOLOTTO, L.; COSTA-HONG, V.; GIORGI, D. M. A.; LOPES, H. F.; DRAGER, L. F.; CONSOLIM-COLOMBO, F. M.; LIMA, J. J. G. De; KRIEGER, E. M.bookPart Hipertensão arterial como fator de risco(2016) LOPES, Heno Ferreira; COLOMBO, Fernanda Marciano Consolim; DRAGER, Luciano Ferreira; BORTOLOTTO, Luiz Aparecido- Association of obstructive sleep apnea with arterial stiffness and nondipping blood pressure in patients with hypertension(2017) JENNER, Raimundo; FATURETO-BORGES, Fernanda; COSTA-HONG, Valeria; LOPES, Heno F.; TEIXEIRA, Sandra H.; MARUM, Elias; GIORGI, Dante A. M.; CONSOLIM-COLOMBO, Fernanda M.; BORTOLOTTO, Luiz A.; LORENZI-FILHO, Geraldo; KRIEGER, Eduardo M.; DRAGER, Luciano F.Whether sex influences the association of obstructive sleep apnea (OSA) with markers of cardiovascular risk in patients with hypertension is unknown. In this study, 95 hypertensive participants underwent carotid-femoral pulse wave velocity, 24-hour ambulatory blood pressure monitoring, echocardiogram, and polysomnography after a 30-day standardized treatment with hydrochlorothiazide plus enalapril or losartan. OSA was present in 52 patients. Compared with non-OSA patients, pulse wave velocity values were higher in the OSA group (men: 11.1 +/- 2.2 vs 12.7 +/- 2.4m/s, P=.04; women: 11.8 +/- 2.4 vs 13.2 +/- 2.2m/s, P=.03). The proportion of diastolic dysfunction was significant in men and women with OSA. Compared with non-OSA patients, nondipping systolic blood pressure in OSA was higher in men (14.3% vs 46.4%) and in women (41.4% vs 65.2%). OSA was independently associated with pulse wave velocity (=1.050; P=.025) and nondipping systolic blood pressure (odds ratio, 3.03; 95% confidence interval, 1.08-8.55; P=.035) in the regression analysis. In conclusion, OSA is independently associated with arterial stiffness and nondipping blood pressure in patients with hypertension regardless of sex.