FERNANDA MARCIANO CONSOLIM COLOMBO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
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- Position Statement on Women's Cardiovascular Health-2022(2022) OLIVEIRA, Glaucia Maria Moraes de; ALMEIDA, Maria Cristina Costa de; MARQUES-SANTOS, Celi; COSTA, Maria Elizabeth Navegantes Caetano; CARVALHO, Regina Coeli Marques de; FREIRE, Claudia Maria Vilas; MAGALHAES, Lucelia Batista Neves Cunha; HAJJAR, Ludhmila Abrahao; RIVERA, Maria Alayde Mendonca; CASTRO, Marildes Luiza de; AVILA, Walkiria Samuel; LUCENA, Alexandre Jorge Gomes de; BRANDAO, Andrea Araujo; MACEDO, Ariane Vieira Scarlatelli; LANTIERI, Carla Janice Baister; POLANCZYK, Carisi Anne; ALBUQUERQUE, Carlos Japhet da Matta; BORN, Daniel; FALCHETO, Eduardo Belisario; BRAGANCA, Erika Olivier Vilela; BRAGA, Fabiana Goulart Marcondes; COLOMBO, Fernanda M. Consolim; JATENE, Ieda Biscegli; COSTA, Isabela Bispo Santos da Silva; RIVERA, Ivan Romero; SCHOLZ, Jaqueline Ribeiro; MELO FILHO, Jose Xavier de; SANTOS, Magaly Arrais dos; BARBOSA, Marcia de Melo; IZAR, Maria Cristina de Oliveira; AZEVEDO, Maria Fatima; MOURA, Maria Sanali; CAMPOS, Milena dos Santos Barros; SOUZA, Olga Ferreira de; MEDEIROS, Orlando Otavio de; SILVA, Sheyla Cristina Tonheiro Ferro da; RIZK, Stephanie Itala; RODRIGUES, Thais de Carvalho Vieira; SALIM, Thais Rocha; LEMKE, Viviana de Mello Guzzo; ALEXANDRE, Elisabeth Regina Giunco
- Effects of Postprandial Lipemia Combined With Disturbed Blood Flow on the Flow-Mediated Dilation, Oxidative Stress, and Endothelial Microvesicles in Healthy Subjects(2022) ARAUJO, Gustavo S. M.; SILVA, Thiago O. C.; GUERRA, Grazia M.; IZAIAS, Joao E.; ROCHA, Helena M. N.; FARIA, Diego; ROCHA, Natalia G.; DALMAZO, Aline Lopes; ARAUJO, Amanda; CONSOLIM-COLOMBO, Fernanda Marciano; ANGELIS, Katia de; IRIGOYEN, Maria C. C.; SALES, Allan R. K.AimsBoth postprandial lipemia (PPL) and disturbed blood flow (DBF) induce endothelial dysfunction. However, the interactive effect of these stimuli on endothelial function is currently unknown. In the present study, we tested whether PPL plus DBF causes a greater reduction in flow-mediated dilation (FMD) than PPL and if this response is associated with elevations in oxidative stress and endothelial microvesicles (EMVs). MethodsEighteen individuals (aged 28 +/- 1yrs, 3 females, and BMI 24.43 +/- 0.8kg/m(2)) randomly underwent two experimental sessions: PPL and PPL plus DBF. FMD and venous blood samples were obtained at baseline and 30, 70, and 110 min after stimulation. PPL was induced by fat overload via mozzarella pizza ingestion and DBF by forearm cuff inflation to 75 mm Hg per 30 min. Lipidic profile, oxidative stress (thiobarbituric acid reactive substances, TBARS; ferric reducing/antioxidant power, FRAP; hydrogen peroxide, H2O2) and EMVs were measured in blood samples. ResultsHypertriglyceridemia was observed in both sessions. Retrograde shear rate and oscillatory index responses were significantly higher in the PPL plus DBF compared with PPL. PPL plus DBF evoked a greater reduction in FMD than did PPL and EMVs, NADPH oxidase, and H2O2 similarly increased in both sessions, but TBARS and FRAP did not change. ConclusionThese data indicate that the association of PPL plus DBF additively impairs endothelium-dependent function in 110 min after stimulus in healthy individuals, despite a similar increase in oxidative stress and EMVs. Further studies are needed to understand the mechanisms associated with the induced-endothelial dysfunction by association of PPL and DBF.
conferenceObject HEART FAILURE IN THE ELDERLY: CARDIAC AMYLOIDOSIS AS AN UNDERDIAGNOSED CAUSE(2022) ALMEIDA, Camila; BORTOLOTTO, Luiz; COLOMBO, Fernanda; FERNANDES, Fabio; SOARES, Fernanda; OLIVEIRA, Renan; CUNHA, Matheus Luan; FUZISSIMA, Bruno; SOUZA, Henrique; PALONE, Andre; FIGUEIREDO, Renan Perycles- The Cholinergic Drug Galantamine Ameliorates Acute Respiratory Distress Syndrome in Mice(2022) FALVEY, Aidan; PALANDIRA, Santhoshi P.; CHANG, Eric H.; CONSOLIM-COLOMBO, Fernanda M.; TRACEY, Kevin J.; PAVLOV, Valentin A.