EDNA MARIA DE ALBUQUERQUE DINIZ
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Pediatria, Faculdade de Medicina - Docente
Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina
Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina
2 resultados
Resultados de Busca
Agora exibindo 1 - 2 de 2
- Early Empiric Antibiotic Use Is Associated With Delayed Feeding Tolerance in Preterm Infants: A Retrospective Analysis(2017) MARTINEZ, Francisco E.; FERRI, Walusa A. G.; LEONE, Clea R.; ALMEIDA, Maria Fernanda Branco de; GUINSBURG, Ruth; MENESES, Jucille do Amaral; VALE, Marynea Silva do; MARBA, Sergio Tadeu Martins; CARVALHO, Werther Brunow de; RUGOLO, Ligia Maria Suppo de Souza; LOPES, Jose Maria de Andrade; RIBEIRO, Manoel A.; PROCIANOY, Renato S.; DUARTE, Jose Luiz Muniz Bandeira; BOUZADA, Maria Candida Ferrarez; FERREIRA, Daniela Marques de Lima Mota; ALVES FILHO, Navantino; DINIZ, Edna Maria de Albuquerque; ZANARDI, Dulce Maria Toledo; TESTONI, Daniela; SANTOS, Cristina Nunes dos; GOMZALEZ, Maria Rafaela Conde; VENZON, Paulyne Stadler; BELIK, JaquesThe causative factors of neonatal feeding intolerance are poorly understood, but potentially related to clinical practices such as empiric antibiotic usage. The objective of this study was to evaluate whether early empiric antibiotic exposure negatively affects preterm infants' enteral feeding tolerance. Data from infants without risk factors for sepsis, 500 to 1499 g birth weight and 24 to 34 weeks gestational age were analyzed. The primary outcomes were the empiric antibiotic exposure effects on the infants' total parenteral nutrition usage duration and prevalence of necrotizing enterocolitis (NEC). Among the 901 infants included, 67 were exposed to early empiric antibiotic. A 50% increase in parenteral nutrition usage duration and a 4-fold greater prevalence of NEC was seen in the early empiric antibiotic-exposed neonates, when compared with control infants (P<0.01). Early empiric antibiotic exposure appears to negatively influence preterm infant feeding tolerance and possibly contributes to NEC.
- Time to change focus? Transitioning from higher neonatal to higher stillbirth mortality in Sao Paulo State, Brazil(2017) ANDREWS, Kathryn; BOURROUL, Maria Lucia Moraes; FINK, Gunther; GRISI, Sandra; FERRER, Paula Scoleze; DINIZ, Edna Maria de Albuquerque; BRENTANI, AlexandraBackground Differential trends in mortality suggest that stillbirths may dominate neonatal mortality in the medium to long run. Brazil has made major efforts to improve data collection on health indicators at granular geographic levels, and provides an ideal environment to test this hypothesis. Our goals were to examine levels and trends in stillbirths and neonatal deaths and the extent to which the mortality burden caused by stillbirths dominates neonatal mortality at the municipality-and state-level. Methods We used data from the Brazilian Ministry of Health's repository on births, fetal, and neonatal deaths (2010 +/- 2014) to calculate stillbirth and neonatal mortality rates for Sao Paulo state's 645 municipalities. Results At the state level, 7.9 per 1000 pregnancies ended in stillbirth (fetal death >22 weeks gestation or fetal weight >500g), but this varied from 0.0 to 28.4 per 1000 across municipalities. 7.9 per 1000 live births also died within the first 28 days. 42% of municipalities had a higher stillbirth rate than neonatal mortality rate, and in 61% of areas with low neonatal mortality (<8.0 per 1000), stillbirth rates exceeded neonatal mortality rates. Conclusions This analysis suggests large variability and inequality in mortality outcomes at the sub-national level. The results also imply that stillbirth mortality may exceed neonatal mortality in Brazil and similar settings in the next few decades, which suggests a need for a shift in policy. This work further underscores the importance of continued research into causes and prevention of stillbirth.