BEATRIZ JULIETA CELESTE

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Departamento de Medicina Preventiva, Faculdade de Medicina
LIM/38 - Laboratório de Epidemiologia e Imunobiologia, Hospital das Clínicas, Faculdade de Medicina

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Assunto: Tropical Medicine ×

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Agora exibindo 1 - 7 de 7
  • article 25 Citação(ões) na Scopus
    Recombinant Leishmania infantum Heat Shock Protein 83 for the Serodiagnosis of Cutaneous, Mucosal, and Visceral Leishmaniases
    (2014) CELESTE, Beatriz Julieta; SANCHEZ, Maria Carmen Arroyo; RAMOS-SANCHEZ, Eduardo Milton; CASTRO, Luiz Guilherme M.; COSTA, Francisco Assis Lima; GOTO, Hiro
    Routine serological diagnoses for leishmaniases, except in visceral cases, are performed using whole-parasite antigens. We used enzyme-linked immunosorbent assay (ELISA) to evaluate the performance of Leishmania infantum rHsp83 compared with L. major-like total promastigote antigen in the diagnosis of cutaneous (CL), mucosal (ML), and visceral leishmaniases (VL). ELISA-rHsp83 was significantly more sensitive than ELISA-L. major-like when considering either CL/ML (P = 0.041) or all leishmaniasis patients (P = 0.013). When samples from other infectious disease patients were evaluated for cross-reactivity, ELISA-rHsp83 was more specific than ELISA-L. major-like, specifically for Chagas disease samples (P < 0.001). We also evaluated the anti-rHsp83 antibody titers months after treatment and observed no significant difference in ML (P = 0.607) or CL (P = 0.205). We recommend ELISA-L. infantum-rHsp83 as a routine confirmatory serological assay for the diagnosis of Leishmania infection because of the high sensitivity, the specificity, and the insignificant cross-reactivity with other infectious diseases.
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    Evaluation of immunochromatographic assay with recombinant antigen K39, using whole blood, serum and oral fluid, in the diagnosis of visceral leishmaniasis in Brazilian endemic areas
    (2015) CELESTE, B. J.; SANCHEZ, M. C. A.; ALMEIDA, R. P. D.; BRANCO, C. M. F. Castelo; LINDOSO, J. A. L.; PANIAGO, A. M. M.; QUEIROZ, I. T.; FUJIMORI, M.; CARAMELO, L. D. C.; GOTO, H.
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    ANTI-LEISHMANIA ANTIBODIES IN SAMPLES OF BLOOD DONORS FROM ENDEMIC AREAS OF BRAZIL
    (2017) FUJIMORI, Mahyumi; CARAMELO, Luiza da Cruz; DORNELAS, Marina Portanova; CELESTE, Beatriz Julieta; WENDEL, Silvano; GOTO, Hiro; SANCHEZ, Maria Carmen
  • article 0 Citação(ões) na Scopus
    Para-kala-azar dermal leishmaniasis in a patient in Brazil: a case report (vol 51, pg 106, 2018)
    (2018) LINDOSO, J. A. L.; MOREIRA, C. H. V.; CELESTE, B. J.; OYAFUSO, L. K. M.; FOLEGATTI, P. M.; ZIJLSTRA, E. E.
  • article 0 Citação(ões) na Scopus
    Case Report: Cutaneous Leishmaniasis in a Rheumatoid Arthritis Patient Receiving Methotrexate
    (2022) AMATO, Valdir Sabbaga; SOUZA, Regina Maia de; FRANCO, Lucas Augusto Moyses; MARTINS, Roberta Cristina Ruedas; SILVA, Camila Alves Maia da; EMORI, Christini Takemi; CELESTE, Beatriz Julieta; CASTANHEIRA, Gabriel Victor; TUON, Felipe Francisco
    The immunosuppressive effect of methotrexate has rarely been associated with reactivation of cutaneous leishmaniasis. Here we present a case of a cutaneous leishmaniasis patient with atypical clinical symptoms without splenomegaly but with cutaneous manifestations after treatment of rheumatoid arthritis with methotrexate and blood recovery of the parasite. Next-generation sequencing was used to identify Leishmania infantum chagasi in the patient's blood sample.
  • article 4 Citação(ões) na Scopus
    Unusual manifestation of genital cutaneous leishmaniasis in an immunocompetent patient from Sao Paulo, Brazil: A case report
    (2021) REIS, Luiza Campos; LINDOSO, Jose Angelo Lauletta; CELESTE, Beatriz Julieta; BRAZ, Lucia Maria Almeida; RAMOS-SANCHEZ, Eduardo Milton; YAMASHIRO-KANASHIRO, Edite Hatsumi; GOTO, Hiro; OYAFUSO, Luiza Keiko Matsuka
    A 31-year-old male patient developed an ulcer on the glans penis that evolved for three months without healing. We diagnosed it as leishmaniasis using polymerase chain reaction. No immunosuppression or associated diseases were observed. The patient was treated with meglumine antimoniate that cured the lesion in a month post-treatment. Here, we report this case of cutaneous leishmaniasis lesion at the unusual location of glans penis in an immunocompetent individual. The lesion likely developed due to the bite of a vector, highlighting the need for considering cutaneous leishmaniasis among differential diagnosis of sexually transmitted diseases in areas endemic for leishmaniasis.
  • article 1 Citação(ões) na Scopus
    Para-kala-azar dermal leishmaniasis in a patient in Brazil: a case report
    (2018) LINDOSO, Jose Angelo Lauletta; MOREIRA, Carlos Henrique Valente; CELESTE, Beatriz Julieta; OYAFUSO, Luiza Keiko Matsuka; FOLEGATTI, Pedro Moreira; ZIJLSTRA, Eduard Evert
    Visceral leishmaniasis is common in Brazil and is caused by Leishmania (Leishmania) infantum/chagasi. Post-kala-azar dermal leishmaniasis frequently follows visceral leishmaniasis caused by L. donovani, and para-kala-azar dermal leishmaniasis refers to an uncommon presentation wherein it occurs simultaneously along with visceral leishmaniasis. While post-kala-azar dermal leishmaniasis only occurs occasionally in L. infantum/chagasi infections, it frequently occurs in patients with concomitant immunosuppression (HIV co-infection). Here, we describe the first case of para-kala-azar dermal leishmaniasis in Brazil. It is important to raise awareness of post-and para-kala-azar dermal leishmaniasis in L. infantum endemic areas as these patients may contribute to visceral leishmaniasis transmission.