MARIO DIEGO TELES CORREIA
Projetos de Pesquisa
Unidades Organizacionais
LIM/51 - Laboratório de Emergências Clínicas, Hospital das Clínicas, Faculdade de Medicina
2 resultados
Resultados de Busca
Agora exibindo 1 - 2 de 2
bookPart Sepse e Inflamação Sistêmica(2016) CORREIA, Mario Diego Teles; MACHADO, Marcel Cerqueira César; SILVA, Fabiano Pinheiro da- CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis(2019) TYMOWSKI, Christian de; HEMING, Nicholas; CORREIA, Mario D. T.; ABBAD, Lilia; CHAVAROT, Nathalie; STANG, Marie-Benedicte Le; FLAMENT, Heloise; BEX, Julie; BOEDEC, Erwan; BOUNAIX, Carine; SOLER-TORRONTERAS, Rafael; DENAMUR, Erick; GALICIER, Lionel; OKSENHENDLER, Eric; FEHLING, Hans Joerg; SILVA, Fabiano Pinheiro da; BENHAMOU, Marc; MONTEIRO, Renato C.; MKADDEM, Sanae BenDirect bacterial recognition by innate receptors is crucial for bacterial clearance. Here, we show that the IgA receptor CD89 is a major innate receptor that directly binds bacteria independently of its cognate ligands IgA and c-reactive protein (CRP). This binding is only partially inhibited by serum IgA and induces bacterial phagocytosis by CD11c(+) dendritic cells and monocytes and/or macrophages, suggesting a physiological role in innate host defense. Blood phagocytes from common variable immunodeficiency patients bind, internalize, and kill bacteria in a CD89-dependent manner, confirming the IgA independence of this mechanism. In vivo, CD89 transgenic mice are protected in two different models of sepsis: a model of pneumonia and the cecal ligation and puncture (CLP) polymicrobial model of infection. These data identify CD89 as a first-line innate receptor for bacterial clearance before adaptive responses can be mounted. Fc receptors may emerge as a class of innate receptors for various bacteria with pleiotropic roles.