JOEL AVANCINI ROCHA FILHO

(Fonte: Lattes)
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Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/08 - Laboratório de Anestesiologia, Hospital das Clínicas, Faculdade de Medicina
LIM/37 - Laboratório de Transplante e Cirurgia de Fígado, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: CINTHIA LANCHOTTE FERREIRA ×

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Agora exibindo 1 - 5 de 5
  • article 0 Citação(ões) na Scopus
    A new heparin fragment decreases liver ischemia-reperfusion injury
    (2022) VASQUES, Enio R.; FIGUEIRA, Estela R. R.; ROCHA-FILHO, Joel A.; LANCHOTTE, Cinthia; XIMENES, Jorge L. S.; NADER, Helena B.; TERSARIOL, Ivarne L. S.; LIMA, Marcelo A.; RODRIGUES, Tiago; CUNHA, Jose E. M.; CHAIB, Eleazar; D'ALBUQUERQUE, Luiz A. C.; GALVAO, Flavio H. F.
  • article 1 Citação(ões) na Scopus
    Hypertonic saline solution decreases oxidative stress in liver hypothermic ischemia
    (2021) NUNES, Giolana; FIGUEIRA, Estela Regina Ramos; ROCHA-FILHO, Joel Avancini; LANCHOTTE, Cinthia; NACIF, Lucas Souto; FERREIRA, Diego Mendes; ROMANO, Vitor Carminatti; ABDO, Emilio Elias; D'ALBUQUERQUE, Luiz Augusto Carneiro; GALVAO, Flavio Henrique Ferreira
    Background: Liver ischemia reperfusion injury is still an unsolved problem in liver surgery and transplantation. In this setting, hypothermia is the gold standard method for liver preservation for trans-plantation. Hypertonic saline solution reduces inflammatory response with better hemodynamic recovery in several situations involving ischemia reperfusion injury. Here, we investigated the effect of hypertonic saline solution in hypothermic liver submitted to ischemia reperfusion injury. Methods: Fifty male rats were divided into 5 groups: SHAM, WI (animals submitted to 40 minutes of partial warm liver ischemia and reperfusion), HI (animals submitted to 40 minutes hypothermic ischemia), HSPI (animals submitted to hypothermic ischemia and treated with 7.5% hypertonic saline solution preischemia), and HSPR (animals submitted to hypothermic ischemia and treated with hypertonic saline solution previously to liver reperfusion). Four hours after reperfusion, the animals were euthanized to collect liver and blood samples. Results: Aspartate aminotransferase and alanine aminotransferase, histologic score, and hepatocellular necrosis were significantly decreased in animals submitted to hypothermia compared with the warm ischemia group. Malondialdehyde was significantly decreased in hypothermic groups with a further decrease when hypertonic saline solution was administrated preischemia. Hypothermic groups also showed decreased interleukin-6, interleukin-10, and tumor necrosis factor-alpha concentrations and better recovery of bicarbonate, base excess, lactate, and glucose blood concentrations. Moreover, hypertonic saline solution preischemia was more effective at controlling serum potassium concentrations. Conclusion: Hypertonic saline solution before hypothermic hepatic ischemia decreases hepatocellular oxidative stress, cytokine concentrations, and promotes better recovery of acid-base disorders secondary to liver ischemia reperfusion.
  • article 12 Citação(ões) na Scopus
    Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion
    (2019) FIGUEIRA, Estela Regina Ramos; ROCHA-FILHO, Joel Avancini; LANCHOTTE, Cinthia; COELHO, Ana Maria Mendonca; NAKATANI, Mauro; TATEBE, Eduardo Ryoiti; LIMA, Jonathan Augusto Venceslau; MENDES, Camilla Oliveira; ARAUJO, Bruno Camargo Rocha Paim de; ABDO, Emilio Elias; D'ALBUQUERQUE, Luiz Carneiro; GALVAO, Flavio Henrique Ferreira
    Objective. The inhalation anesthetic sevoflurane has presented numerous biological activities, including anti-inflammatory properties and protective effects against tissue ischemic injury. This study investigated the metabolic, hemodynamic, and inflammatory effects of sevoflurane pre- and postconditioning for short periods in the rescue of liver ischemia-reperfusion (IR) injury using a rat model. Materials and Methods. Twenty Wistar rats were divided into four groups: sham group, control ischemia group (partial warm liver ischemia for 45min followed by 4h of reperfusion), SPC group (administration of sevoflurane 2.5% for 15min with 5min of washout before liver IR), and SPPoC group (administration of sevoflurane 2.5% for 15min before ischemia and 20min during reperfusion). Results. All animals showed a decrease in the mean arterial pressure (MAP) and portal vein blood flow during ischemia. After 4h of reperfusion, only the SPPoC group had MAP recovery. In both the SPC and SPPoC groups, there was a decrease in the ALT level and an increase in the bicarbonate and potassium serum levels. Only the SPPoC group showed an increase in the arterial blood ionized calcium level and a decrease in the IL-6 level after liver reperfusion. Therefore, this study demonstrated that sevoflurane preconditioning reduces hepatocellular injury and acid-base imbalance in liver ischemia. Furthermore, sevoflurane postconditioning promoted systemic hemodynamic recovery with a decrease in inflammatory response.
  • article 0 Citação(ões) na Scopus
    Hexafluoroisopropanol decreases liver ischemia-reperfusion injury by downregulation of high mobility group box-1 protein
    (2022) MOSCOSO, Agustin Vintimilla; FIGUEIRA, Estela Regina Ramos; ROCHA-FILHO, Joel Avancini; URNER, Martin; LANCHOTTE, Cinthia; JUKEMURA, Jose; XIMENES, Jorge Luiz Saraiva; NAHAS, Sergio Carlos; D'ALBUQUERQUE, Luiz Augusto Carneiro; GALVAO, Flavio Henrique Ferreira
    Liver ischemia-reperfusion (IR) injury is associated with poor outcome after liver transplantation and liver resections. Hexafluoroisopropanol (HFIP) is a tri-fluorinated metabolites of volatile anesthetics and has modulatory effects on inflammation that have been observed mainly in cell culture experiments. In this survey, we investigated the effects of HFIP in a rat model of normothermic hepatic ischemia-reperfusion injury. Twenty-four male Wistar rats were randomized into three groups: (1) control in which animals were submitted to 30 min of partial liver ischemia with resection of non-ischemic liver lobes immediate after reperfusion, (2) pre-ischemia (PI) group in which animals received intravenous HFIP (67 mg/kg) 5 min before liver ischemia, and (3) pre-reperfusion (PR) group in which animals received intravenous HFIP (67 mg/kg) 5 min before reperfusion. Four hours after reperfusion, all animals were euthanized for sample collection. Aspartate and alanine transaminases, glucose, and high mobility group box-1 (HMGB-1) protein concentrations showed a significant decreased, and malondialdehyde was increased in the PR group compared with control and PI groups. Interleukin 6 (IL-6) was increased in the PI group compared with control and PR groups. IL-10 and -12 were increased in the PR and PI groups, respectively, when compared with the control group. Glucose decreased in the PR when compared with the control group. Post-conditioning with HFIP led to a decrease in hepatocellular injury and was associated with a downregulation of HMGB-1. The HFIP resulted in a better control of inflammatory response to ischemia-reperfusion even without causing a reduction in oxidative stress.
  • article 4 Citação(ões) na Scopus
    Creatinine-lactate score predicts mortality in non-acetaminophen-induced acute liver failure in patients listed for liver transplantation
    (2021) FIGUEIRA, Estela Regina Ramos; ROCHA-FILHO, Joel Avancini; LANCHOTTE, Cinthia; NACIF, Lucas Souto; HADDAD, Luciana Bertocco de Paiva; ASSALIN, Adriana Rochetto; SHINKADO, Yumi Ricucci; VINTIMILLA, Agustin Moscoso; GALVAO, Flavio Henrique Ferreira; D'ALBUQUERQUE, Luiz Augusto Carneiro
    Background The aim of this study was to analyze prognostic indicators of in-hospital mortality among patients listed for urgent liver transplantation (LT) for non-acetaminophen (APAP)-induced acute liver failure (ALF). Methods ALF patients listed for LT according to the King's College Criteria were retrospectively reviewed. Variables were recorded from medical records and electronic databases (HCMED and RedCap). Results The study included 100 patients, of which 69 were subject to LT and 31 died while waiting for LT. Patients were 35.5 +/- 14.73 years old, and 78% were females. The main etiologies were virus (17%), drug-induced (32%), autoimmune (15%), and indeterminate hepatitis (31%). The prioritization-to-LT time interval was 1.5 days (0-9). The non-LT patients showed higher lactate (8.71 +/- 5.36 vs. 4.48 +/- 3.33 mmol/L), creatinine (229 +/- 207 vs. 137 +/- 136 mu m/L), MELD (44 +/- 8 vs. 38 +/- 8), and BiLE scores (15.8 +/- 5.5 vs. 10.3 +/- 4.1) compared to LT patients (p < 0.05). Multiple logistic regression analysis identified creatinine and lactate as independent prognostic factors, and a creatinine-lactate (CL) score was developed. ROC analysis showed that creatinine, lactate, MELD, BiLE, and CL scores had considerable specificity (71-88%), but only BiLE, lactate, and CL presented high sensitivities (70%, 80%, and 87% respectively). AUCs were 0.696 for creatinine, 0.763 for lactate, 0.697 for MELD, 0.814 for BiLE, and 0.835 for CL. Conclusions CL and BiLE scores predict mortality with more accuracy than MELD in patients with ALF during prioritization time. Creatinine and lactate are independent prognostic factors for mortality.