JOEL FAINTUCH
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Gastroenterologia, Faculdade de Medicina - Docente
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
bookPart Complicações nuricionais após cirurgia bariátrica(2016) FAINTUCH, Joel; FAINTUCH, Jacob J.bookPart Síndrome metabólica, diabetes e obesidade: conceitos e rotinas básico(2016) FAINTUCH, Joel; FAINTUCH, Jacob J.bookPart Funções e aberrações dos micronutrientes(2016) FAINTUCH, Joel; FAINTUCH, Jacob J.; MORAIS, Álvaro A. C.bookPart Necessidades e Carências de Micronutrientes(2016) FAINTUCH, JoelbookPart Princípios de nutrição na infecção por HIV/aids (Sida)(2016) FAINTUCH, Joel; FAINTUCH, Jacob J.bookPart Bases da assistência nutricional nas hepatopatias(2016) FAINTUCH, Joel; FAINTUCH, Jacob J.; MORAIS, Álvaro A. C.- Functional investigation of bone implant viability using radiotracers in a new model of osteonecrosis(2016) SCHIPER, Luis; FAINTUCH, Bluma Linkowski; BADARO, Roberto Jose da Silva; OLIVEIRA, Erica Aparecida de; CHAVEZ, Victor E. Arana; CHINEN, Elisangela; FAINTUCH, JoelOBJECTIVES: Conventional imaging methods are excellent for the morphological characterization of the consequences of osteonecrosis; however, only specialized techniques have been considered useful for obtaining functional information. To explore the affinity of radiotracers for severely devascularized bone, a new mouse model of isolated femur implanted in a subcutaneous abdominal pocket was devised. To maintain animal mobility and longevity, the femur was harvested from syngeneic donors. Two technetium-99m-labeled tracers targeting angiogenesis and bone matrix were selected. METHODS: Medronic acid and a homodimer peptide conjugated with RGDfK were radiolabeled with technetium-99m, and biodistribution was evaluated in Swiss mice. The grafted and control femurs were evaluated after 15, 30 and 60 days, including computed tomography (CT) and histological analysis. RESULTS: Radiolabeling achieved high (>95%) radiochemical purity. The biodistribution confirmed good blood clearance 1 hour after administration. For Tc-99m-hydrazinonicotinic acid (HYNIC)-E-[c(RGDfK)(2), remarkable renal excretion was observed compared to Tc-99m-methylene diphosphonate (MDP), but the latter, as expected, revealed higher bone uptake. The results obtained in the control femur were equal at all time points. In the implanted femur, Tc-99m-HYNIC-E-[c(RGDfK)(2) uptake was highest after 15 days, consistent with early angiogenesis. Regarding Tc-99m-MDP in the implant, similar uptake was documented at all time points, consistent with sustained bone viability; however, the uptake was lower than that detected in the control femur, as confirmed by histology. CONCLUSIONS: 1) Graft viability was successfully diagnosed using radiotracers in severely ischemic bone at all time points. 2) Analogously, indirect information about angiogenesis could be gathered using Tc-999m-HYNIC-E-[c(RGDfK)(2). 3) These techniques appear promising and warrant further studies to determine their potential clinical applications.
bookPart Técnicas cirúrgicas convencionais em cirurgia bariátrica e metabólica(2016) FAINTUCH, Joel; FAINTUCH, Jacob J.- Androgen and Estrogen Shifts in Men Before and After Bariatric Surgery and Links to Vitamins and Trace Elements(2016) ROSENBLATT, Alberto; FAINTUCH, Joel; CECCONELLO, IvanAndrogens and estrogens play a key role regarding sexual life and reproduction. Along with hypotestosteronemia, obese men exhibit a 2-fold increase in estradiol concentration, adversely influencing these parameters. Estrogens and adipokines also influence bone metabolism, exerting a direct effect on vitamin D, calcium homeostasis and bone health. Bariatric procedures normalize some sex hormones, and may reverse several obesity-related conditions. Estrogens levels may remain elevated postoperatively, and despite its protective effect on the skeleton, bariatric patients are more prone to fractures when compared to the general population. Multiple nutritional deficits are common after bariatric interventions, and hypozincemia is the most likely to negatively influence reproductive parameters. Zinc is an essential element for normal spermatogenesis, and severe hypozincemia is associated with infertility in both sexes. Vitamin D also acts as a regulator of several enzymes involved in steroid hormone production, and its deficiency could impair reproductive function. Few studies have addressed changes in sex hormones and in reproductive function in the male bariatric population, as they represent a minority of surgical candidates. Although obesity rates and burden are similar for both sexes, society is more lenient with the obese male. Moreover, 73 % of overweight/obese men are satisfied with their health, causing body weight and obesity-related health problems to increase when they opt for bariatric surgery. In the present article, we discuss shifts of sex hormones before and after bariatric surgery, surgery impact on semen quality, skeletal health and nutrients, and new research directions regarding links between vitamin D, zinc, androgens and reproduction.