JOEL FAINTUCH
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Gastroenterologia, Faculdade de Medicina - Docente
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- Systemic inflammation and carotid diameter in obese patients: pilot comparative study with flaxseed powder and cassava powder(2011) FAINTUCH, J.; BORTOLOTTO, L. A.; MARQUES, P. C.; FAINTUCH, J. J.; FRANCA, J. I.; CECCONELLO, I.Background: Botanical omega-3 fatty acid (alpha-linolenic acid/ALA) has been shown to alleviate the prothrombotic and proinflammatory profile of metabolic syndrome, however clinical protocols are still scarce. Aiming to focus an obese population, a pilot study was designed. Methods: Morbidly obese candidates for bariatric surgery (n = 29, age 463 +/- 5.2 years), 82.8% females (24/29), BMI 44.9 +/- 5.2 kg/m(2), with C-reactive protein/CRP > 5 mg/L were recruited. Twenty were randomized and after exclusions, 16 were available for analysis. Flaxseed powder (60 g/day, 10 g ALA) and isocaloric roasted cassava powder (60 g/day, fat-free) were administered in a double-blind routine for 12 weeks. Results: During flaxseed consumption neutrophil count decreased and fibrinogen, complement C4, prothrombin time and carotid diameter remained stable, whereas placebo (cassava powder) was associated with further elevation of those measurements. Conclusions: Inflammatory and coagulatory markers tended to exhibit a better outlook in the flaxseed group. Also large-artery diameter stabilized whereas further increase was noticed in controls. These findings raise the hypothesis of a less deleterious cardiovascular course in seriously obese subjects receiving a flaxseed supplement. (Nutr Hosp. 2011;26:208-213) DOI:10.3305/nh.2011.26.1.4974
- Four-Year Hospital Resource Utilization After Bariatric Surgery: Comparison with Clinical and Surgical Controls(2011) HAYASHI, Silvia Yoko; FAINTUCH, Joel; FRANCA, Joao Italo Dias; CECCONELLO, IvanConsumption of healthcare has been shown to diminish after bariatric treatment, but utilization of hospital services has not been well documented. Aiming to assess this question, a retrospective study with females was designed. Yearly outpatient appointments, hospital admissions, emergency department visits, and total biochemical tests during 4 years were registered and compared with the preoperative year. Population (N = 176, all females) comprised 94 bariatric candidates submitted to Roux-en-Y gastric bypass (RYGB; age 41.4 +/- 10.1 years, BMI 52.2 +/- 10.6 kg/m(2)), 34 nonoperated obese controls (age 49.4 +/- 8.3 years, BMI 33.8 +/- 5.5 kg/m(2)), and 48 colorectal surgical controls (age 44.8 +/- 8.6 years, BMI 23.8 +/- 4.7 kg/m(2)). Nonbariatric obese patients were fairly well-matched, moderate differences involving higher age and comorbidities. Surgical controls were similarly aged but suffered from less comorbidities. Obese nonsurgical participants displayed the highest demand for outpatient visits (10.5 +/- 0.9/year, P < 0.001) followed by bariatric and colorectal cases (5.7 +/- 0.2 and 3.5 +/- 0.8, respectively, P = 0.042). Also biochemical measurements were most often required by clinical controls (61.5 +/- 5.1/year, P < 0.001), whereas no difference was detected between bariatric and colorectal patients (28.9 +/- 2.2 and 33.8 +/- 7.7/year, respectively). Elective and emergency admissions were similar for all groups, and part of the postbariatric assistance was related to plastic surgery. RYGB patients needed 45.8% less outpatient visits and 53.0% less laboratory tests than nonoperated moderately obese cases, even including esthetic operations. Results were comparable to those observed after elective colorectal surgery and remained fairly stable during 4 years.
- Semen Analysis and Fertility Rates after Bariatric Surgery in Males(2017) ROSENBLATT, Alberto; FAINTUCH, Joel; PAJECKI, Denis; SANTO, Marco Aurelio; FAINTUCH, Salomao; CECCONELLO, IvanBackground: Obesity poses challenges to male reproduction, but the effect of bariatric surgery on semen parameters and fertility is debated. This study evaluates Roux-en-Y gastric bypass (RYGB) influence on these variables. Methods: Seventy-nine sexually active men attempting to conceive with a partner were stratified into four groups: Group 1 (n = 23)-bariatric follow-up >= 5 years; Group 2 (n = 23)-mean bariatric follow-up 2 years; Group 3-obese controls (n = 18); Group 4-lean controls (n = 15). Groups 2, 3, and 4 were matched for age; Groups 1, 2, and 3 were matched for body mass index (BMI). Sexual quality of life questionnaire for males (SQOL-M), fasting blood glucose, C-reactive protein, vitamin D, zinc, total testosterone (TT), and free testosterone (FT), estradiol (E2), sex hormone-binding globulin (SHBG), and semen parameters were investigated. Results: SQOL-M scores increased; vitamin D was low in most of Group 2 and Group 3 participants, negatively correlating with BMI (p < 0.01). TT, FT, and SHBG improved postoperatively; however, E2 remained elevated. Semen aberrations occurred in 57.1% of Group 2 patients and BMI correlated with oligoasthenoteratospermia. Scant bariatric men fathered a child (13.0% preoperatively, 4.3% postoperatively, not significant). Conclusion: Semen abnormalities and subfertility were observed after RYGB, despite improved androgenic profile and SQOL-M. Possible negative impacts of hyperestrogenism and hypovitaminosis D on semen parameters warrant further studies.
- ILSI Brazil International Workshop on Functional Foods: a narrative review of the scientific evidence in the area of carbohydrates, microbiome, and health(2013) LATULIPPE, Marie E.; MEHEUST, Agnes; AUGUSTIN, Livia; BENTON, David; BERCIK, Premysl; BIRKETT, Anne; ELDRIDGE, Alison L.; FAINTUCH, Joel; HOFFMANN, Christian; JONES, Julie Miller; KENDALL, Cyril; LAJOLO, Franco; PERDIGON, Gabriela; PRIETO, Pedro Antonio; RASTALL, Robert A.; SIEVENPIPER, John L.; SLAVIN, Joanne; MENEZES, Elizabete Wenzel deTo stimulate discussion around the topic of 'carbohydrates' and health, the Brazilian branch of the International Life Sciences Institute held the 11th International Functional Foods Workshop (1 2 December 2011) in which consolidated knowledge and recent scientific advances specific to the relationship between carbohydrates and health were presented. As part of this meeting, several key points related to dietary fiber, glycemic response, fructose, and impacts on satiety, cognition, mood, and gut microbiota were realized: 1) there is a need for global harmonization of a science-based fiber definition; 2) low-glycemic index foods can be used to modulate the postprandial glycemic response and may affect diabetes and cardiovascular outcomes; 3) carbohydrate type may influence satiety and satiation; glycemic load and glycemic index show links to memory, mood, and concentration; 4) validated biomarkers are needed to demonstrate the known prebiotic effect of carbohydrates; 5) negative effects of fructose are not evident when human data are systematically reviewed; 6) new research indicates that diet strongly influences the microbiome; and 7) there is mounting evidence that the intestinal microbiota has the ability to impact the gut-brain axis. Overall, there is much promise for development of functional foods that impact the microbiome and other factors relevant to health, including glycemic response (glycemic index/glycemic load), satiety, mood, cognition, and weight management.
- Lung microbiome and origins of the respiratory diseases(2023) BELIZáRIO, J.; GARAY-MALPARTIDA, M.; FAINTUCH, J.The studies on the composition of the human microbiomes in healthy individuals, its variability in the course of inflammation, infection, antibiotic therapy, diets and different pathological conditions have revealed their intra and inter-kingdom relationships. The lung microbiome comprises of major species members of the phylum Bacteroidetes, Firmicutes, Actinobacteria, Fusobacteria and Proteobacteria, which are distributed in ecological niches along nasal cavity, nasopharynx, oropharynx, trachea and in the lungs. Commensal and pathogenic species are maintained in equilibrium as they have strong relationships. Bacterial overgrowth after dysbiosis and/or imbalanced of CD4+ helper T cells, CD8+ cytotoxic T cells and regulatory T cells (Treg) populations can promote lung inflammatory reactions and distress, and consequently acute and chronic respiratory diseases. This review is aimed to summarize the latest advances in resident lung microbiome and its participation in most common pulmonary infections and pneumonia, community-acquired pneumonia (CAP), ventilator-associated pneumonia (VAP), immunodeficiency associated pneumonia, SARS-CoV-2-associated pneumonia, acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). We briefly describe physiological and immunological mechanisms that selectively create advantages or disadvantages for relative growth of pathogenic bacterial species in the respiratory tract. At the end, we propose some directions and analytical methods that may facilitate the identification of key genera and species of resident and transient microbes involved in the respiratory diseases’ initiation and progression.