ANTONIO CHARLYS DA COSTA
Projetos de Pesquisa
Unidades Organizacionais
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
LIM/46 - Laboratório de Parasitologia Médica, Hospital das Clínicas, Faculdade de Medicina
LIM/46 - Laboratório de Parasitologia Médica, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load(2012) SANABANI, Sabri Saeed; NUKUI, Youko; PEREIRA, Juliana; COSTA, Antonio Charlys da; OLIVEIRA, Ana Carolina Soares de; PESSOA, Rodrigo; LEAL, Fabio Eudes; SEGURADO, Aluisio C.; KALLAS, Esper Georges; SABINO, Ester CerdeiraBackground: The Interleukin 28B (IL28B) rs12979860 polymorphisms was recently reported to be associated with the human T-cell leukemia virus type 1 (HTLV-1) proviral load (PvL) and the development of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Methods: In an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL levels and clinical status in 112 unrelated Brazilian subjects (81 HTLV-1 asymptomatic carriers, 24 individuals with HAM/TSP and 7 with Adult T cell Leukemia/Lymphoma (ATLL)). Results: All 112 samples were successfully genotyped and their PvLs compared. Neither the homozygote TT nor the heterozygote CT mutations nor the combination genotypes (TT/CT) were associated with a greater PvL. We also observed no significant difference in allele distribution between asymptomatic carriers and patients with HTLV-1 associated HAM/TSP. Conclusions: Our study failed to support the previously reported positive association between the IL28B rs12979860 polymorphisms and an increased risk of developing HAM/TSP in the Brazilian population.
- Frequency of subtype B and F1 dual infection in HIV-1 positive, Brazilian men who have sex with men(2012) SANABANI, Sabri Saeed; OLIVEIRA, Ana Carolina Soares de; COSTA, Antonio Charlys da; MELILLO, Mariana; SOLANGE, Sauer Katia Cristina Bassichetto; OLIVEIRA, Maria Santos; COSTA, Priscilla Ramos; TOMIYAMA, Claudia; TOMIYAMA, Helena Tomoko Iwashita; CERDEIRA, Ester; ESPER, Sabino; KAL, Georges
- Genetic variability and high proportion of HIV-1 BF1 recombinant strains among vertically infected children in Sao Paulo, Brazil(2012) OLIVEIRA, Ana Carolina Soares de; COSTA, Antonio Charlys da; MARTINEZ, Vanessa Pouza; MAIDANA, Maria Teresa; SUCCI, Giret Regina Celia de Menezes; SABINO, Ester Cerdeira; KALLAS, Esper Georges; SANABANI, Sabri Saeed