RAFAEL GIOVANE MISSE
Projetos de Pesquisa
Unidades Organizacionais
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
2 resultados
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- Pain in individuals with idiopathic inflammatory myopathies, other systemic autoimmune rheumatic diseases, and without rheumatic diseases: A report from the COVAD study(2023) SHINJO, Samuel Katsuyuki; KIM, Minchul; HOFF, Leonardo Santos; MISSE, Rafael Giovani; SEN, Parikshit; NAVEEN, R.; DAY, Jessica; CORDEIRO, Rafael Alves; GONCALVES JUNIOR, Jucier; CHATTERJEE, Tulika B.; LILLEKER, James B.; AGARWAL, Vishwesh; KARDES, Sinan; MILCHERT, Marcin; GHEITA, Tamer; SALIM, Babur; VELIKOVA, Tsvetelina; GRACIA-RAMOS, Abraham Edgar; PARODIS, Ioannis; O'CALLAGHAN, Albert Selva; NIKIPHOROU, Elena; MAKOL, Ashima; TAN, Ai Lyn; CAVAGNA, Lorenzo A.; SAAVEDRA, Miguel A.; ZIADE, Nelly; KNITZA, Johannes; KUWANA, Masataka; NUNE, Arvind; DISTLER, Oliver; CHINOY, Hector; AGARWAL, Vikas; AGGARWAL, Rohit; GUPTA, LatikaObjectives: To compare pain intensity among individuals with idiopathic inflammatory myopathies (IIMs), other systemic autoimmune rheumatic diseases (AIRDs), and without rheumatic disease (wAIDs).Methods: Data were collected from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study, an international cross-sectional online survey, from December 2020 to August 2021. Pain experienced in the preceding week was assessed using numeral rating scale (NRS). We performed a negative binomial regression analysis to assess pain in IIMs subtypes and whether demographics, disease activity, general health status, and physical function had an impact on pain scores.Results: Of 6988 participants included, 15.1% had IIMs, 27.9% had other AIRDs, and 57.0% were wAIDs. The median pain NRS in patients with IIMs, other AIRDs, and wAIDs were 2.0 (interquartile range [IQR] = 1.0-5.0), 3.0 (IQR = 1.0-6.0), and 1.0 (IQR = 0-2.0), respectively (P < 0.001). Regression analysis adjusted for gender, age, and ethnicity revealed that overlap myositis and antisynthetase syndrome had the highest pain (NRS = 4.0, 95% CI = 3.5-4.5, and NRS = 3.6, 95% CI = 3.1-4.1, respectively). An additional association between pain and poor functional status was observed in all groups. Female gender was associated with higher pain scores in almost all scenarios. Increasing age was associated with higher pain NRS scores in some scenarios of disease activity, and Asian and Hispanic ethnicities had reduced pain scores in some functional status scenarios.Conclusion: Patients with IIMs reported higher pain levels than wAIDs, but less than patients with other AIRDs. Pain is a disabling manifestation of IIMs and is associated with a poor functional status.
- Effect of exercise training on fatigue and pain in patients with systemic autoimmune myopathies: A systematic review(2021) MISSE, Rafael Giovani; BORGES, Isabela Bruna Pires; DANTOS, Alexandre Moura dos; GUPTA, Latika; SHINJO, Samuel KatsuyukiSystemic autoimmune myopathies (or idiopathic inflammatory myopathies) are a wide group of rare rheumatic diseases characterized by muscle weakness due to muscle inflammation. Recent evidence has continually reinforced the relevance of the perception of pain and fatigue as parameters of notable contribution to reducing the quality of life of these patients. However, due to the multidimensional characteristic of these variables, few studies address the effects of pharmacological and non-pharmacological therapies, such as exercise training on these variables. With regard to patients with systemic autoimmune myopathies, the outcomes related to the effects of exercise training are focused on muscle strength and endurance, few explore the effects on the perception of pain and fatigue. Given this, studies that review systematically the available evidence of the effects of exercise training on these perceptions can contribute to management of this parameter in clinical practice. Given this context, the present study aims to review systematically the effectiveness of exercise training specifically on the perception of pain and fatigue.