ALUISIO AUGUSTO COTRIM SEGURADO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina - Docente
LIM/49 - Laboratório de Protozoologia, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/49 - Laboratório de Protozoologia, Hospital das Clínicas, Faculdade de Medicina - Líder
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- Epidemiology of gonorrhoea: a global perspective(2019) KIRKCALDY, Robert D.; WESTON, Emily; SEGURADO, Aluisio C.; HUGHES, GwendaAlthough understanding the local epidemiology of gonorrhoea is critical for local efforts, understanding the multinational epidemiology may support development of national and international prevention and control policies and strategies. In this paper, current epidemiology of gonorrhoea is reviewed through an international lens and with a focus on selected populations. The World Health Organization (WHO) estimates that similar to 87 million new gonococcal infections occurred among people aged 15-49 years in 2016. Gonorrhoea rates are rising in many countries. Gay, bisexual and other men who have sex with men, racial or ethnic minorities, Indigenous populations and sex workers appear to bear disproportionate burdens of gonorrhoea. International travel can facilitate spread of gonorrhoea, including resistant strains, across international borders. Critical gaps in epidemiological knowledge are highlighted, including data on gonorrhoea among transgender persons and the burden of extragenital gonorrhoea. Even as further data are gathered, action - informed by currently available data - is needed now to confront this growing international threat.
- Malaria Disease Recommendations for Solid Organ Transplant Recipients and Donors(2018) PIERROTTI, Ligia Camera; LEVI, Marilyn Eckstein; SANTI, Silvia Maria Di; SEGURADO, Aluisio Cotrim; PETERSEN, Eskild
- Home-based interventions to promote physical activity for people living with HIV - a systematic review(2023) SANTOS, Elisabete Cristina Morandi dos; LIMA, Luiz Rodrigo Augustemak de; YOONG, Serene; GUERRA, Paulo Henrique; SEGURADO, Aluisio CotrimAlthough physical activity (PA) improves the physical, mental, and social outcomes of people living with HIV (PLH), multiple barriers prevent them from exercising. In this systematic review, we investigated the effect of home-based interventions to promote physical activity (HBI) among PLH. Randomised trials and quasi-experimental studies published in English until March 2020 were sought in five databases. Independent reviewers performed data extraction, risk of bias assessment and pragmatic-explanatory (PRECIS-2) evaluation of study characteristics. Outcomes included engagement in PA, body composition, cardiorespiratory fitness, strength, metabolic disturbances, and quality of life (QoL). Out of 480 retrieved references, six studies met inclusion criteria. Interventions lasted 12-48 weeks and involved 400 individuals (57.8% women). Ninety-eight (24.5%) participants completed interventions, but dropout rates varied considerably (5.0-54.5%). Resulted showed increased PA (two studies) and improved cardiorespiratory fitness or strength (three and two studies, respectively). Four studies demonstrated reduction of waist circumference and increase in lean body mass. QoL improved in two of three studies. We conclude HBI (aerobic and/or resistance exercises) may contribute to improve PA and/or cardiorespiratory fitness, body composition, strength and QoL of PLH. Further investigation using multi-centre standardised protocols is warranted to provide stronger evidence of their effectiveness in health promotion for PLH.
- Familiar barriers still unresolved-a perspective on the Zika virus outbreak research response(2019) KOOPMANS, Marion; LAMBALLERIE, Xavier de; JAENISCH, Thomas; ROSENBERGER, Kerstin D.; MORALES, Ivonne; MARQUES, Ernesto T. A.; VIANA, Isabelle F. T.; BRASIL, Patricia; RABELLO, Renata; AVELINO-SILVA, Vivian I.; SEGURADO, Aluisio; ALEXANDER, Neal; MAYAUD, Philippe; NETTO, Eduardo Martins; TAMI, Adriana; BETHENCOURT, Sarah; MIRANDA, Maria Consuelo; LOZANO, Anyela; SORIA, Carmen; CISNEROS, Silvia P. Salgado; GOTUZZO, Eduardo; GUZMAN, Maria G.; RODRIGUEZ, Pedro A. M.; LOPEZ-GATELL, Hugo; HEGEWISCH-TAYLOR, Jennifer; BORJA-ABURTO, Victor Hugo; BONILLA, Cesar R. Gonzalez; HOEN, Bruno; ROODE, Martine van; ROCKX, BarryResearch is an important component of an effective response to the increasing frequency of widespread infectious disease outbreaks. In turn, the ability to do such studies relies on willingness of partners in different regions to collaborate and the capacity to mount a rapid research response. The EU-funded ZIKAlliance Consortium has initiated a multicountry epidemiological, clinical, and laboratory research agenda to determine the incidence, risk factors, and outcomes of Zika virus infection in pregnant women and their children. We reviewed the timeline of patient cohort initiation in relation to the Zika virus epidemic and mapped key events regarding funding, regulatory approvals, and site preparation during this timeline. We then assessed barriers and delays that the international research team experienced through a systematic telephone interview. We have identified three major bottlenecks in the implementation of a swift response: the absence of a timeline for the funding process, delays in regulatory and ethical approval, and the challenging logistics of laboratory support, including diagnostics. These bottlenecks illustrate the clear and urgent need for implementing a strong and permanent global emerging infectious diseases research capacity that has structured funding, enables long-term partnerships, and develops basic clinical and laboratorial research and a response infrastructure that is ready to deploy.