MICHELE TATIANA PEREIRA TOMITAO

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Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: TATIANE KATSUE FURUYA ×

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  • article 19 Citação(ões) na Scopus
    Association between Polymorphisms in Inflammatory Response-Related Genes and the Susceptibility, Progression and Prognosis of the Diffuse Histological Subtype of Gastric Cancer
    (2018) FURUYA, Tatiane K.; JACOB, Carlos E.; TOMITAO, Michele T. P.; CAMACHO, Lizeth C. C.; RAMOS, Marcus F. K. P.; ELUF-NETO, Jose; ALVES, Venancio A. F.; ZILBERSTEIN, Bruno; CECCONELLO, Ivan; RIBEIRO JR., Ulysses; CHAMMAS, Roger
    The chronic inflammatory microenvironment and immune cell dysfunction have been described as critical components for gastric tumor initiation and progression. The diffuse subtype is related to poor clinical outcomes, pronounced inflammation, and the worst prognosis. We investigated the association of polymorphisms in inflammatory response-related genes (COX-2, OGG1, TNFB, TNFA, HSPA1L, HSPA1B, VEGFA, IL17F, LGALS3, PHB, and TP53) with gastric cancer susceptibility, progression and prognosis in a Brazilian sample, focusing on the diffuse subtype. We also performed the analysis regarding the total sample of cases (not stratified for tumor subtypes), allowing the comparison between the findings. We further investigated the polymorphisms in linkage disequilibrium and performed haplotype association analyses. In the case-control study, rs1042522 (TP53) was associated with a stronger risk for developing gastric cancer in the sample stratified for diffuse subtype patients when compared to the risk observed for the total cases; CTC haplotype (rs699947 / rs833061 / rs2010963 VEGFA) was associated with risk while rs699947 was associated with protection for gastric malignancy in the total sample. Regarding the associations with the clinicopathological features of gastric cancer, for the diffuse subtype we found that rs699947 and rs833061 (VEGFA) were associated with outcomes related to a worse progression while rs5275 (COX-2), rs909253 (TNFB), and rs2227956 (HSPA1L) were associated to a better progression of the disease. In the total sample, rs699947 and rs833061 (VEGFA), rs4644 (LGALS3), and rs1042522 (TP53) were able to predict a worse progression while rs5275 (COX-2), rs2227956 (HSPA1L), and rs3025039 (VEGFA) a better progression. Besides, rs909253 (TNFB) predicted protection for the overall and disease-free survivals for gastric cancer. In conclusion, these results helped us to clarify the potential role of these polymorphisms in genes involved in the modulation of the inflammatory response in the pathogenesis of gastric cancer.
  • article 3 Citação(ões) na Scopus
    Cyclooxygenase-2 gene polymorphisms and susceptibility to colorectal cancer in a Brazilian population
    (2017) TOMITAO, Michele Tatiana Pereira; NAHAS, Sergio Carlos; KUBRUSLY, Marcia Saldanha; FURUYA, Tatiane Katsue; DINIZ, Marcio Augusto; MARIE, Suely Kazue Nagahashi; SAFATLE-RIBEIRO, Adriana Vaz; ELUF-NETO, Jose; CECCONELLO, Ivan; RIBEIRO JR., Ulysses
    Background: Multi-ethnicity of Brazilian population displays high levels of genomic diversity. Polymorphism may detect people at higher risk of developing cancer, distinctive response to treatment, and prognosis. Cyclooxygenase-2 (COX-2) is induced in response to growth factors and cytokines, and is expressed in inflammatory diseases, precancerous lesions and colorectal cancer (CRC). The aim of this study was to evaluate the influence of COX-2 -1195A > G and 8473T > C polymorphisms as a risk factor of developing CRC. Methods: We evaluated COX-2 Single Nucleotide Polymorphism (SNP) of 230 CRC patients and 196 healthy controls by Real-Time Polymerase Chain Reaction. Results: Populations were in Hardy-Weinberg equilibrium (HWE), except for control group of 8473T > C SNP. The frequencies were similar in both groups for genotypes and haplotypes. There was no association between studied polymorphisms and risk of CRC. Conclusions: The gene polymorphisms studied do not participate in the genetic susceptibility to CRC in a Brazilian population.
  • conferenceObject
    Association between polymorphisms in inflammatory response related-genes and the susceptibility, progression, and prognosis of gastric cancer.
    (2018) FURUYA, Tatiane K.; JACOB, Carlos E.; TOMITAO, Michele T.; CORDOBA-CAMACHO, Lizeth C.; RAMOS, Marcus K.; ELUF-NETO, Jose; ALVES, Venancio A.; ZILBERSTEIN, Bruno; CECCONELLO, Ivan; RIBEIRO-JUNIOR, Ulysses; CHAMMAS, Roger