MICHELE TATIANA PEREIRA TOMITAO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
conferenceObject Polymorphisms in the cyclooxygenase-2 (COX-2) gene, vascular endothelial growth factor (VEGF) and methylenetetrahydrofolate reductase (MTHFR) gene in patients with hepatocellular carcinoma and hepatitis C virus infection(2017) CARVALHO, S. C. R. D.; VASCONCELOS, L. R. S.; CARMO, R. F.; AROUCHA, D. C. B. L.; TOMITAO, M. T.; RIBEIRO JR., U.; PEREIRA, L. M. M. B.; OLIVEIRA, C. P.; CARRILHO, F. J.conferenceObject ECONOMIC ANALYSIS OF HEPATO CELLULAR CARCINOMA TREATMENT BY SEVERITY OF DISEASE(2017) TANI, J. A.; CAMPOLINA, A. G.; DECIMONI, T. C.; TOMITAO, M.; FERREIRA, L. A.conferenceObject Wild Homozygous VEGF-A and COX-2 Gene Polymorphisms Are Associated to Worst Prognosis in Patients With Colorectal Cancer (CRC)(2013) TOMITAO, Michele T.; COTTI, Guilherme C.; KUBRUSLY, Marcia S.; PELEGRINELLI-ZAIDAN, Evelise; SAFATLE-RIBEIRO, Adriana V.; PATZINA, Rosely A.; ELUF-NETO, Jose; CECCONELLO, Ivan; NAHAS, Sergio C.; RIBEIRO, UlyssesconferenceObject RESOURCE UTILIZATION AND TREATMENT OF PATIENT WITH HEPATOCELULLAR CARCINOMA - A MICROCOSTING ANALYSIS(2017) TANI, J. A.; DECIMONI, T. C.; FERREIRA, L. A.; TOMITAO, M.; CAMPOLINA, A. G.- Carnoy's solution is an adequate tissue fixative for routine surgical pathology, preserving cell morphology and molecular integrity(2015) PEREIRA, Marina A.; DIAS, Andre R.; FARAJ, Sheila F.; CIRQUEIRA, Cinthya dos S.; TOMITAO, Michele T.; NAHAS, Sergio Carlos; RIBEIRO JR., Ulysses; MELLO, Evandro S. deAims: To compare Carnoy's solution (CS) and 10% neutral buffered formalin solution (NBF) as tissue fixatives in colorectal cancer specimens. Methods and results: Surgical specimens from patients with colorectal cancer were analysed. Three groups were studied, as follows: group 1 consisted of 16 paired samples fixed in CS and NBF; and groups 2 and 3 consisted of 14 prospective and 80 retrospective samples, respectively, both randomized for fixation in CS or NBF. Groups 1 and 2 were analysed for amount, quality and integrity of DNA. Morphological analysis, including some of the usual special stains and polymerase chain reaction (PCR), were also performed for group 1, and Sanger sequencing for group 2. Immunohistochemical (IHC) reactions for mismatch repair proteins were studied in groups 1 and 3. Fixative performances were similar for morphology, special stains, and IHC reactions, as well as for the amount, quality and integrity of extracted DNA. PCR amplification was not possible in two cases from CS group 1. Sanger sequencing gave conclusive results for the CS samples tested. Conclusions: Carnoy's solution and NBF are equivalent fixatives for colorectal cancer specimens and are adequate for routine utilization in surgical and molecular pathology.
- Cyclooxygenase-2 gene polymorphisms and susceptibility to colorectal cancer in a Brazilian population(2017) TOMITAO, Michele Tatiana Pereira; NAHAS, Sergio Carlos; KUBRUSLY, Marcia Saldanha; FURUYA, Tatiane Katsue; DINIZ, Marcio Augusto; MARIE, Suely Kazue Nagahashi; SAFATLE-RIBEIRO, Adriana Vaz; ELUF-NETO, Jose; CECCONELLO, Ivan; RIBEIRO JR., UlyssesBackground: Multi-ethnicity of Brazilian population displays high levels of genomic diversity. Polymorphism may detect people at higher risk of developing cancer, distinctive response to treatment, and prognosis. Cyclooxygenase-2 (COX-2) is induced in response to growth factors and cytokines, and is expressed in inflammatory diseases, precancerous lesions and colorectal cancer (CRC). The aim of this study was to evaluate the influence of COX-2 -1195A > G and 8473T > C polymorphisms as a risk factor of developing CRC. Methods: We evaluated COX-2 Single Nucleotide Polymorphism (SNP) of 230 CRC patients and 196 healthy controls by Real-Time Polymerase Chain Reaction. Results: Populations were in Hardy-Weinberg equilibrium (HWE), except for control group of 8473T > C SNP. The frequencies were similar in both groups for genotypes and haplotypes. There was no association between studied polymorphisms and risk of CRC. Conclusions: The gene polymorphisms studied do not participate in the genetic susceptibility to CRC in a Brazilian population.
conferenceObject Association between polymorphisms in inflammatory response related-genes and the susceptibility, progression, and prognosis of gastric cancer.(2018) FURUYA, Tatiane K.; JACOB, Carlos E.; TOMITAO, Michele T.; CORDOBA-CAMACHO, Lizeth C.; RAMOS, Marcus K.; ELUF-NETO, Jose; ALVES, Venancio A.; ZILBERSTEIN, Bruno; CECCONELLO, Ivan; RIBEIRO-JUNIOR, Ulysses; CHAMMAS, Roger- VEGF-A and Cox-2 gene polymorphisms and susceptibility to colorectal cancer in Brazilian population(2013) TOMITAO, Michele T. P.; KUBRUSLY, Marcia S.; COTTI, Guilherme C.; ZAIDAN, Evelise P.; SAFATLE-RIBEIRO, Adriana V.; MARIE, Suely K. N.; CECCONELLO, Ivan; NAHAS, Sergio C.; RIBEIRO, Ulysses
conferenceObject ADVANCED DUODENAL AND AMPULLARY ADENOMATOSIS IN A BRAZILIAN POPULATION OF FAMILIAL ADENOMATOUS POLYPOSIS: PROSPECTIVE CLINICAL AND MOLECULAR STUDY.(2017) NAVA, M. Sulbaran; CAMPOS, F.; RIBEIRO JUNIOR, U.; COUDRY, R.; MEIRELES, S.; LISBOA, B.; KISHI, H.; SAKAI, P.; MOURA, E. de; BUSTAMANTE-LOPEZ, L.; TOMITAO, M.; NAHAS, S.; RIBEIRO, A. SafatleconferenceObject Jarid1b protects from metformin-induced chemosensitization to cisplatin through p53 downregulation in NSCLC(2018) TORTELLI JR., Tharcisio Citrangulo; TAMURA, Rodrigo Esaki; TOMITAO, Michele Tatiana Pereira; BUSTOS, Silvina Odete; SAITO, Renata de Freitas; LEANDRINI, Sarah Milani de Moraes; JACOMASSI, Mayara D'Aurea; RIBEIRO JR., Ulysses; STRAUSS, Bryan Erik; CHAMMAS, Roger