ROGERIO DE SOUZA

(Fonte: Lattes)
Índice h a partir de 2011
29
Lattes
ResearcherID
ORCID
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina - Líder

Filtros

Mostrar mais
Limpar filtros

Configurações

search.filters.applied.f.dateIssued: 2014 ×

Resultados de Busca

Agora exibindo 1 - 10 de 24
  • article 17 Citação(ões) na Scopus
    Disfunção ventricular esquerda em pacientes com suspeita de hipertensão arterial pulmonar
    (2014) GAVILANES, Francisca; ALVES JR., Jose Leonidas; FERNANDES, Caio; PRADA, Luis Felipe Lopes; JARDIM, Carlos Viana Poyares; MORINAGA, Luciana Tamie Kato; DIAS, Bruno Arantes; HOETTE, Susana; SOUZA, Rogerio
    Objective: To evaluate the role of right heart catheterization in the diagnosis of pulmonary arterial hypertension (PAH). Methods: We evaluated clinical, functional, and hemodynamic data from all patients who underwent right heart catheterization because of diagnostic suspicion of PAH-in the absence of severe left ventricular dysfunction (LVD), significant changes in pulmonary function tests, and ventilation/perfusion lung scintigraphy findings consistent with chronic pulmonary thromboembolism between 2008 and 2013 at our facility. Results: During the study period, 384 patients underwent diagnostic cardiac catheterization at our facility. Pulmonary hypertension (PH) was confirmed in 302 patients (78.6%). The mean age of those patients was 48.7 years. The patients without PH showed better hemodynamic profiles and lower levels of B-type natriuretic peptide. Nevertheless, 13.8% of the patients without PH were categorized as New York Heart Association functional class III or IV. Of the 218 patients who met the inclusion criteria, 40 (18.3% and 178 (81.7%) were diagnosed with PH associated with LVD (PH-LVD) and with PAH, respectively. The patients in the HP-LVD group were significantly older than were those in the PAH group (p < 0.0001). Conclusions: The proportional difference between the PAH and PH-LVD groups was quite significant, considering the absence of echocardiographic signs suggestive of severe LVD during the pre-catheterization investigation. Our results highlight the fundamental role of cardiac catheterization in the diagnosis of PAH, especially in older patients, in whom the prevalence of LVD that has gone undiagnosed by non-invasive tests is particularly relevant.
  • article 12 Citação(ões) na Scopus
    Lodenafil treatment in the monocrotaline model of pulmonary hypertension in rats
    (2014) POLONIO, Igor Bastos; ACENCIO, Milena Marques Pagliareli; PAZETTI, Rogerio; ALMEIDA, Francine Maria de; SILVA, Brbara Soares da; PEREIRA, Karina Aparecida Bonifacio; SOUZA, Rogerio
    We assessed the effects of Iodenafil on hemodynamics and inflammation in the rat model of monocrotaline-induced pulmonary hypertension (PH). Thirty male Sprague-Dawley rats were randomly divided into three groups: control; monocrotaline (experimental model); and Iodenafila (experimental model followed by Iodenafil treatment, p.o., 5 mg/kg daily for 28 days) Mean pulmonary artery pressure (mPAP) was obtained by right heart catheterization. We investigated right ventricular hypertrophy (RVH) and IL-1 levels in lung fragments. The number of cases of RVH was significantly higher in the monocrotaline group than in the Iodenafil and control groups, as were mPAP and IL-1 levels. We conclude that Iodenafil can prevent monocrotaline-induced PH, RVH, and inflammation.
  • article 41 Citação(ões) na Scopus
    Quality of life as a prognostic marker in pulmonary arterial hypertension
    (2014) FERNANDES, Caio J. C. S.; MARTINS, Barbara C. S.; JARDIM, Carlos V. P.; CICONELLI, Rozana M.; MORINAGA, Luciana K.; BREDA, Ana Paula; HOETTE, Susana; SOUZA, Rogerio
    Background: Improvement in quality of life together with better survival are the ultimate goals in the treatment of pulmonary arterial hypertension (PAH) patients. The objective of this study was to evaluate the health-related quality of life (HRQL) of pulmonary arterial hypertension (PAH) patients with the SF-36 generic questionnaire and to identify the prognostic implication of this assessment. Methods: Fifty-four consecutive newly diagnosed PAH patients (WHO classification group I) in a single PAH reference center were included. Patients were evaluated at baseline for clinical and hemodynamic parameters, and they subsequently received first-line therapy with either an endothelin receptor antagonist or a phosphodiesterase-5 inhibitor. After 16 weeks of specific PAH therapy, all patients were re-evaluated using a 6MWT and a SF 36 questionnaire, and then they were followed up for at least 36 months. Results: After treatment, the patients demonstrated an improved 6MWT (414 +/- 124 m vs. 440 +/- 113 m, p = 0.001). Specific PAH therapy also improved the HRQL scores. Patients with a baseline Physical Component Score (PCS) higher than 32 had a better survival rate than those who had a score under 32 (p = 0.04). Similarly, patients with a PCS of at least a 38 after the 16 week therapy period had a better survival rate when compared with those who did not achieve this value (p = 0.016). Unlike the absolute PCS values, the post-treatment PCS variability was unable to predict better survival rates (p = 0.58). Conclusions: Our findings suggest that HRQL is associated with prognosis in PAH. Furthermore, achieving pre-determined PCS scores might represent a specific goal to be reached in treatment-to-target strategies.
  • article 4 Citação(ões) na Scopus
    New steps for the international consolidation of the Brazilian Journal of Pulmonology
    (2014) CARVALHO, Carlos Roberto Ribeiro; BALDI, Bruno Guedes; JARDIM, Carlos Viana Poyares; CARUSO, Pedro; SOUZA, Rogerio
  • article 31 Citação(ões) na Scopus
    Immunopathological aspects of schistosomiasis-associated pulmonary arterial hypertension
    (2014) MAUAD, Thais; POZZAN, Geanette; LANCAS, Tatiana; OVERBEEK, Maria J.; SOUZA, Rogerio; JARDIM, Carlos; DOLHNIKOFF, Marisa; MELLO, George; PIRES-NETO, Ruy Camargo; BERNARDI, Fabiola del Carlo; GRUNBERG, Katrien
    Objectives: Pulmonary hypertension is a lethal complication of chronic hepatosplenic schistosomiasis. Little is known of the underlying (immuno-)histopathological characteristics of lung vasculopathy. Methods: We characterized vasculopathy and inflammation in lung tissue of 10 patients with Schistosomiasis-associated PH (SCH-PH) in comparison to 22 idiopathic pulmonary arterial hypertension (IPAH) patients and 10 normal controls. SCH-PH cases were younger than controls. Results: Plexiform lesions and/or angiomatoid lesions were found in 10/10 SCH-PH, and 19/22 IPAH patients (chi(2) p = 0.22). Lung granulomas with Schistosoma eggs were found in 2/10 of SCH-PH cases. PAH cases had increased peri-arterial density of CD3+ T cells, chymase+ and tryptase+ mast cells when compared to controls (p <= 0.047). SCH-PH showed increased density of CD4+ cells when compared to controls (p = 0.025), paralleled by an increased density of dendritic CD83+ cells when compared to both controls and IPAH patients (p <= 0.022). Conclusion: Both SCH-PH and IPAH feature plexogenic arteriopathy and increased periarterial T cell and mast cell density. SCH-PH and IPAH differ only with respect to the density of dendritic CD83+ cells. These findings imply ongoing antigenic stimulation in SCH-PH, yet a pattern of pulmonary vasculopathy similar to IPAH, suggestive of a final common pathway in their pathogenesis of PAH.
  • article 3 Citação(ões) na Scopus
  • conferenceObject
    Cardiovascular Magnetic Resonance Imaging In Newly Diagnosed, Treatment Naive Precapillary Pulmonary Hypertension
    (2014) HOETTE, S.; CREUZE, N.; MONTANI, D.; GUNTHER, S.; TERNACLE, J.; SIMONNEAU, G.; SOUZA, R.; HUMBERT, M.; CHEMLA, D.
  • conferenceObject
    Right Ventricular Function Is Related To Resistive Rather Than To Elastic Pulmonary Arterial Properties In Precapillary Pulmonary Hypertension: A Cmr Study
    (2014) CREUZE, N.; HOETTE, S.; MONTANI, D.; GUNTHER, S.; GIRED, B.; SIMONNEAU, G.; SOUZA, R.; HUMBERT, M. J. C.; CHEMLA, D.
  • conferenceObject
    Macitentan reduces the risk of morbidity and mortality irrespective of the presence or absence of right ventricular (RV) impairment: Results from the randomised SERAPHIN trial in pulmonary arterial hypertension (PAH)
    (2014) SITBON, Olivier; CHANNICK, Richard N.; DELCROIX, Marion; GHOFRANI, Hossein-Ardeschir; JANSA, Pavel; BRUN, Franck -Olivier Le; MEHTA, Sanjay; PERCHENET, Loic; PULIDO, Tomas; RUBIN, Lewis J.; SASTRY, B. K. S.; SIMONNEAU, Gerald; SOUZA, Rogerio; TORBICKI, Adam; GALIE, Nazzareno
  • article 1 Citação(ões) na Scopus
    Updated clinical classification of pulmonary hypertension (vol 62, pg D34, 2013)
    (2014) SIMONNEAU, G.; GATZOULIS, M. A.; ADATIA, I; CELERMAJER, D.; DENTON, C.; GHOFRANI, A.; SANCHEZ, Gomez M. A.; KUMAR, R. K.; LANDZBERG, M.; MACHADO, R. F.; OLSCHEWSKI, H.; ROBBINS, I. M.; SOUZA, R.