GERALDO LORENZI FILHO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/63, Hospital das Clínicas, Faculdade de Medicina - Líder
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/63, Hospital das Clínicas, Faculdade de Medicina - Líder
65 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 65
conferenceObject Effects of CPAP on Metabolic Syndrome in Patients with Obstructive Sleep Apnea: The TREATOSA-MS Randomized Controlled Trial(2020) GIAMPA, S. Q.; FREITAS, L. S.; FURLAN, S. F.; MACEDO, T. A.; LEBKUCHEN, A.; CARDOZO, K. H. M.; MARTINS, F. C.; AZAM, I. F. B.; COSTA-HONG, V.; BAPTISTA, M. L.; ROCHITTE, C. E.; BORTOLOTTO, L. A.; LORENZI-FILHO, G.; DRAGER, L. F.- Weight Gain Induced by Continuous Positive Airway Pressure in Patients with Obstructive Sleep Apnea Is Mediated by Fluid Accumulation: A Randomized Crossover Controlled Trial(2021) HERCULANO, Sara; GRAD, Gustavo F.; DRAGER, Luciano F.; ALBUQUERQUE, Andre L. P. de; MELO, Camila M.; LORENZI-FILHO, Geraldo; GENTA, Pedro R.
- Patients With OSA Are Perceived as Younger Following Treatment With CPAP(2019) YAGIHARA, Fabiana; LORENZI-FILHO, Geraldo; SANTOS-SILVA, RogerioBACKGROUND The aim of this study was to compare the effects of CPAP treatment and placebo intervention on the facial appearance of patients with OSA. METHODS Patients with severe OSA were randomized to receive either CPAP treatment or nasal dilator (placebo) intervention for 1 month. The sequence was interposed by 15 days of washout with no treatment. Patients were evaluated by using questionnaires, polysomnography, and facial photographs at baseline and at the end of both interventions. In an electronic survey, the photographs were presented in a randomized order to 704 observers who rated the perceived age, health, attractiveness, and tiredness of the patients. Observers were unaware of the patients' conditions. RESULTS: Thirty patients (age, 46 +/- 9 years; 21 men; apnea-hypopnea index, 61.8 +/- 26.2) were evaluated. During each intervention period, patients used CPAP 6.0 +/- 1.7 h per night on 94% of the nights and the placebo intervention on 98% of the nights. After CPAP treatment, patients were rated younger (47.9 +/- 3.5 years) than they appeared at baseline (53.9 +/- 4.0 years) and following the placebo treatment (49.8 +/- 3.7 years) (P < .001). Linear regression analysis identified that CPAP adherence, total sleep time, and percentage of total sleep time with oxyhemoglobin saturation < 90% were predictors of a decreased age rating following CPAP treatment. CONCLUSIONS Patients with severe OSA had a younger appearance following 1 month of CPAP treatment. This benefit can serve as an additional source of motivation for patients with OSA to comply with CPAP treatment and may facilitate OSA management.
- OSA, Short Sleep Duration, and Their Interactions With Sleepiness and Cardiometabolic Risk Factors in Adults The ELSA-Brasil Study(2019) DRAGER, Luciano F.; SANTOS, Ronaldo B.; SILVA, Wagner A.; PARISE, Barbara K.; GIATTI, Soraya; AIELO, Aline N.; SOUZA, Silvana P.; FURLAN, Sofia F.; LORENZI-FILHO, Geraldo; LOTUFO, Paulo A.; BENSENOR, Isabela M.BACKGROUND: OSA and short sleep duration (SSD) are frequently associated with daytime symptoms and cardiometabolic deregulation. However, the vast majority of studies addressing OSA have not evaluated SSD, and vice versa. Our aim was to evaluate the association of OSA, SSD, and their interactions with sleepiness and cardiometabolic risk factors in a large cohort of adults. METHODS: Consecutive subjects from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) participated in clinical evaluations, sleep questionnaires, home sleep monitoring, and actigraphy. OSA was defined as an apnea-hypopnea index >= 15 events/hour. SSD was defined by a mean sleep duration < 6 h. RESULTS: Data from 2,064 participants were used in the final analysis (42.8% male; mean age, 49 +/- 8 years). The overall frequency of OSA and SSD were 32.9% and 27.2%, respectively. Following an adjustment for multiple confounding factors, excessive daytime sleepiness was independently associated with SSD (OR, 1.448; 95% CI, 1.172-1.790) but not with OSA (OR, 1.107; 95% CI, 0.888-1.380). The SSD interaction with OSA was not significant. Prevalent obesity (OR, 3.894; 95% CI, 3.077-4.928), hypertension (OR, 1.314; 95% CI, 1.035-1.667), and dyslipidemia (OR, 1.251; 95% CI, 1.006-1.555) were independently associated with OSA but not with SSD. Similarly, the interactions of OSA with SSD were not significant. An additional analysis using < 5 h for SSD or continuous sleep duration did not change the lack of association with the cardiometabolic risk factors. CONCLUSIONS: Objective SSD but not OSA was independently associated with daytime sleepiness. By contrast, OSA, but not SSD, was independently associated with obesity, hypertension, and dyslipidemia.
conferenceObject Accuracy Of Non-Dipping Blood Pressure In Predicting Obstructive Sleep Apnea In Patients SuBMItted To Ambulatory Blood Pressure Monitoring(2017) FURLAN, S. F.; GENTA-PEREIRA, D. C.; OMOTE, D. D. Q.; GIORGI, D.; BORTOLOTTO, L. A.; LORENZI-FILHO, G.; DRAGER, L. F.conferenceObject Neck Electrical Impedance Tomography For Continuous And Non-Invasive Evaluation Of Upper Airway Patency During Sleep(2014) PICCIN, V. S.; GENTA, P. R.; CAMARGO, E. L. D. B.; SCHORR, F.; ANDRADE, R. G. S.; TORSANI, V.; SARDINHA, P. S.; GREGORIO, M. G.; CARVALHO, C. R. R.; AMATO, M. B.; LORENZI-FILHO, G.conferenceObject Predictors Of Obstructive Sleep Apnoea Severity In Patients Enrolled In The Sleep Apnoea Cardiovascular Endpoint ""save"" Trial(2015) HNIN, K.; ANTIC, N. A.; ANDERSON, C.; HEELEY, E.; ZHONG, N.; BARBE, F.; CHAI-COETZER, C.; LORENZI-FILHO, G.; ZHANG, X.; LUO, Y. -M.; OU, Q.; CHEN, R.; LIU, Z. -H.; DU, B. -L.; MEDIANO, O.; MCARDLE, N.; TRIPATHI, M.; WOODMAN, R.; MCEVOY, R. D.conferenceObject Obstructive Sleep Apnea Is Extremely Common And Associated With Myocardial Ischemia In Patients With Refractory Angina(2014) GEOVANINI, G. R.; PEREIRA, A. C.; GOWDAK, L. H. W.; DOURADO, L. O.; POPPI, N.; CESAR, L. M.; DRAGER, L. F.; LORENZI-FILHO, G.- Different Craniofacial Characteristics Predict Upper Airway Collapsibility in Japanese-Brazilian and White Men(2016) SCHORR, Fabiola; KAYAMORI, Fabiane; HIRATA, Raquel P.; DANZI-SOARES, Naury J.; GEBRIM, Eloisa M.; MORIYA, Henrique T.; MALHOTRA, Atul; LORENZI-FILHO, Geraldo; GENTA, Pedro R.BACKGROUND: OSA pathogenesis is complex and may vary according to ethnicity. The anatomic component predisposing to OSA is the result of the interaction between bony structure and upper airway soft tissues and can be assessed using passive critical closing pressure (Pcrit). We hypothesized that Japanese-Brazilians and whites present different predictors of upper airway collapsibility, suggesting different causal pathways to developing OSA in these two groups. METHODS: Male Japanese-Brazilians (n = 39) and whites (n = 39) matched for age and OSA severity were evaluated by full polysomnography, Pcrit, and upper airway and abdomen CT scans for determination of upper airway anatomy and abdominal fat, respectively. RESULTS: Pcrit was similar between the Japanese-Brazilians and the whites (-1.0 +/- 3.3 cm H2O vs -0.4 +/- 3.1 cm H2O, P = .325). The Japanese-Brazilians presented smaller upper airway bony dimensions (cranial base, maxillary, and mandibular lengths), whereas the whites presented larger upper airway soft tissue (tongue length and volume) and a greater imbalance between tongue and mandible (tongue/mandibular volume ratio). The cranial base angle was associated with Pcrit only among the Japanese-Brazilians (r = -0.535, P < .01). The tongue/mandibular volume ratio was associated with Pcrit only among the whites (r = 0.460, P < .01). Obesity-related variables (visceral fat, BMI, and neck and waist circumferences) showed a similar correlation with Pcrit in the Japanese-Brazilians and the whites. CONCLUSIONS: Japanese-Brazilians and whites present different predictors of upper airway collapsibility. Although craniofacial bony restriction influenced Pcrit only in the Japanese-Brazilians, an anatomic imbalance between tongue and mandible volume influenced Pcrit among the whites. These findings may have therapeutic implications regarding how to improve the anatomic predisposition to OSA across ethnicities.
- Effect of Continuous Positive Airway Pressure on Blood Pressure in Obstructive Sleep Apnea with Cardiovascular Disease(2019) RYSWYK, Emer Van; ANDERSON, Craig S.; BARBE, Ferran; LOFFLER, Kelly A.; LORENZI-FILHO, Geraldo; LUO, Yuanming; QUAN, Weiwei; WANG, Jiguang; ZHENG, Danni; MCEVOY, R. Doug