FERNANDA BUENO FUSCO
Projetos de Pesquisa
Unidades Organizacionais
LIM/10 - Laboratório de Lípides, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
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conferenceObject N-acetylcystein Reduces Lipid Peroxidation and Advanced Glycation Related to Prevention of Macrophage Endoplasmic Reticulum Stress Induced by Albumin Isolated from Rats With Chronic Kidney Disease(2014) MACHADO, Juliana T.; IBORRA, Rodrigo T.; FUSCO, Fernanda B.; CASTILHO, Gabriela; PINTO, Raphael S.; MACHADO-LIMA, Adriana; NAKANDAKARE, Edna R.; SHIMIZU, Maria Heloisa M.; SEGURO, Antonio Carlos; CATANOZI, Sergio; PASSARELLI, MarisaconferenceObject CHROMATOGRAPHIC ANALYSIS OF THE LIPID FRACTIONS IN OBESE CLIENT-OWNED DOGS(2012) JERICO, M. M.; CHIQUITO, F. C.; FUSCO, F.; CATANOZI, S.; NUNES, V. S.; NAKANDAKARE, E. R.Obesity, a metabolic disease of multifactorial origin, impairs the health and longevity of individuals. Dyslipidemia, a common condition in obese animals, is usually associated to a variety of clinical problems, which include gastrointestinal alterations, hepatic lipidosis, atherosclerosis and metabolic syndrome. The aim of the study was to characterize the lipid profile and lipoprotein fractions in obese dogs (n=20) and compare them with control dogs (n=10), selected from a veterinary hospital environment. Lipoproteins (LP) were isolated by fast protein liquid chromatography (FPLC) system and plasma total cholesterol (TC) and triglycerides (TG) concentrations were measured by enzymatic methods. In control group, TC was 193±44 mg/dL (mean±SD) (percentage distribution among LP fractions: VLDL-C 2.34%, LDL-C 15.79%, HDL-C 81.86%); Plasma TG concentration was 50± 15 mg/dL (LP fraction percentage distribution: VLDL-TG 39.17%, LDL-TG 35.9%, HDL-TG 24.94%). In obese dogs, plasma TC was 227± 73 mg/dL (VLDL-C 3,325%, LDL-C21.64%, HDL-C 75.03%) whereas the TG values were 87.9 ± 52 mg/dL (VLDL-TG 61.98%, LDL-TG 24.71%, HDL-TG 13.36%). When compared to the normal dogs, the animals with obesity presented a significant increase (p<0.01) in plasmaTG and VLDL-TG levels as well as a lower HDL-TG concentration. There were not significant alterations in cholesterol fractions or TC between groups although they presented proportionally higher levels of TC, and LDL-C as well as lower HDL-C. It was concluded that obese dogs present a significant difference when compared to normal dogs in relation to triglyceride metabolism and their VLDL and HDL fractions, which has been previously shown in experimental model of obese canine insulin resistance. These findings suggest a higher risk of metabolic complications in obese client-owned dogs, like diabetes, hepatobiliary diseases and o f blood flow disturbances, like atherosclerosis.conferenceObject LOW-SALT DIET INDUCES ATHEROSCLEROSIS INDEPENDENT OF LOWERING BLOOD PRESSURE IN HYPERTENSIVE MICE(2016) CATANOZI, S.; FUSCO, F.; GOMES, D.; BISPO, K.; TOLEDO, V.; BARBEIRO, D.; CAPELOZZI, V.; FURUKAWA, L.; VELOSA, A. P.; TEODORO, W.; HEIMANN, J.; QUINTAO, E.; PASSARELLI, M.; NAKANDAKARE, E.