THAYSE REGINA BRUGGEMANN

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LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: PEDRO FRANCISCO GIAVINA-BIANCHI JUNIOR ×

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  • conferenceObject
    Bordetella Pertussis Whole-Cell Vaccine Inhibits Specific IgE, Inflammation and Airway Remodeling in a Murine Model of Asthma
    (2015) AUN, Marcelo Vivolo; ARANTES-COSTA, Fernanda; SARAIVA-ROMANHOLO, Beatriz Mangueira; ALMEIDA, Francine Maria; REGINA-BRUEGGERMANN, Thayse; MARTINS, Milton Arruda; KALIL, Jorge; GIAVINA-BIANCHI, Pedro
  • conferenceObject
    Inhibition of Inflammation and Mucus Production By Bordetella Pertussis Whole-Cell Vaccine in a Murine Model of Allergic Rhinitis
    (2016) AUN, Marcelo Vivolo; ARANTES-COSTA, Fernanda; ALMEIDA, Francine Maria; BRUGGERMANN, Thayse Regina; SARAIVA-ROMANHOLO, Beatriz Mangueira; GENARO, Isabella S.; MARTINS, Milton Arruda; KALIL, Jorge; GIAVINA-BIANCHI, Pedro
  • article 8 Citação(ões) na Scopus
    Sensitization by subcutaneous route is superior to intraperitoneal route in induction of asthma by house dust mite in a murine mode
    (2015) AUN, Marcelo Vivolo; SARAIVA-ROMANHOLO, Beatriz Mangueira; ALMEIDA, Francine Maria de; BRüGGEMANN, Thayse Regina; KALIL, Jorge; MARTINS, Milton de Arruda; ARANTES-COSTA, Fernanda Magalhães; GIAVINA-BIANCHI, Pedro
    ABSTRACT Objective To develop a new experimental model of chronic allergic pulmonary disease induced by house dust mite, with marked production of specific immunoglobulin E (IgE), eosinophilic inflammatory infiltrate in the airways and remodeling, comparing two different routes of sensitization. Methods The protocol lasted 30 days. BALB/c mice were divided into six groups and were sensitized subcutaneously or intraperitoneally with saline (negative control), Dermatophagoides pteronyssinus (Der p) 50 or 500mcg in three injections. Subsequently they underwent intranasal challenge with Der p or saline for 7 days and were sacrificed 24 hours after the last challenge. We evaluated the titration of specific IgE anti-Der p, eosinophilic density in peribronchovascular space and airway remodeling. Results Both animals sensitized intraperitoneally and subcutaneously produced specific IgE anti-Der p. Peribronchovascular eosinophilia increased only in mice receiving lower doses of Der p. However, only the group sensitized with Der p 50mcg through subcutaneously route showed significant airway remodeling. Conclusion In this murine model of asthma, both pathways of sensitization led to the production of specific IgE and eosinophilia in the airways. However, only the subcutaneously route was able to induce remodeling. Furthermore, lower doses of Der p used in sensitization were better than higher ones, suggesting immune tolerance. Further studies are required to evaluate the efficacy of this model in the development of bronchial hyperresponsiveness, but it can already be replicated in experiments to create new therapeutic drugs or immunotherapeutic strategies.