LUANA DE MENDONCA OLIVEIRA

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LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina

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Revista / Livro: Allergy Asthma and Clinical Immunology ×

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  • article 19 Citação(ões) na Scopus
    Preconception allergen sensitization can induce B10 cells in offspring: a potential main role for maternal IgG
    (2017) OLIVEIRA, Marlia Garcia de; OLIVEIRA, Luana de Mendonca; LIRA, Aline Aparecida de Lima; SGNOTTO, Fabio da Ressureicao; DUARTE, Alberto Jose da Silva; SATO, Maria Notomi; VICTOR, Jefferson Russo
    Background: The mechanisms through which allergies can be inhibited after preconception immunization with allergens are not fully understood. We aimed to evaluate whether maternal immunization can induce a regulatory B (B10) cell population in offspring in concert with allergy inhibition. Methods: C57BL/6 females were or were not immunized with OVA and were mated with normal WT males. Their offspring were evaluated at 3 days of age or 20 days after neonatal immunization. Human peripheral B cells from atopic and non-atopic individuals were also evaluated. Results: Preconception OVA immunization induced B10 cells in offspring, and IL-10 production appeared to be critical for FcyRIIB upregulation in offspring B cells. Murine and human IL-10-producing B cells responded in vitro to IgG according to the atopic repertoire of the cells. Conclusions: Our results reveal that maternal immunization induces allergen-specific B10 cells in offspring and a pivotal role for the IgG repertoire in IL-10 production by murine and human B cells.
  • article 11 Citação(ões) na Scopus
    Maternal immunization with ovalbumin or Dermatophagoides pteronyssinus has opposing effects on Fc gamma RIIb expression on offspring B cells
    (2014) LIRA, Aline Aparecida de Lima; OLIVEIRA, Marilia Garcia de; OLIVEIRA, Luana Mendona de; DUARTE, Alberto Jose da Silva; SATO, Maria Notomi; VICTOR, Jefferson Russo
    Background: Over the last decade, our group has demonstrated that murine preconception immunization with allergens has a protective effect on allergy development in offspring. The murine model used in the present study allowed us to compare allergy induction by ovalbumin (OVA) and dust mite extract from Dermatophagoides pteronyssinus (Dp). Findings: Female mice were immunized with OVA or Dp. Pups from immunized and non-immune mothers were immunized at 3 days old (do) with the same antigen used for the maternal immunization. The offspring were analyzed at 20 do. Preconceptional immunization with OVA or Dp did not increase maternal IgE serum levels, although the immunizations induced an increase in allergen-specific IgG1 Ab levels. Offspring serum analyses revealed that maternal immunization with OVA suppressed IgE production only in offspring immunized with OVA. Both preconception immunization protocols inhibited cellular influx into the airways of immunized offspring compared with controls. Similar frequencies of offspring IgM + B cells were found in the OVA- and Dp-immunized groups compared with their respective control groups. Moreover, preconception immunization with OVA enhanced Fc gamma RIIb expression on OVA-immunized offspring B cells. In contrast, decreased Fc gamma RIIb expression was detected on Dp-immunized offspring B cells compared with cells from the offspring of non-immune mothers. Conclusions: Together, these results show that preconception OVA immunization and Dp immunization can inhibit allergy development but have opposite effects on Fc gamma RIIb expression on offspring B cells.