PERCIVAL DEGRAVA SAMPAIO BARROS
Índice h a partir de 2011
26
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
12 resultados
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- Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort(2016) LANDI, Margarita; MALDONADO-FICCO, Hernan; PEREZ-ALAMINO, Rodolfo; MALDONADO-COCCO, Jose A.; CITERA, Gustavo; ARTURI, Pablo; SAMPAIO-BARROS, Percival D.; ALVARADO, Diana E. Flores; BURGOS-VARGAS, Ruben; SANTOS, Elena; PALLEIRO, Daniel; GUTIERREZ, Miguel A.; VIEYRA-SOUSA, Elsa; PIMENTEL-SANTOS, Fernando; PAIRA, Sergio O.; BERMAN, Alberto; BARREZUETA, Claudia Vera; VAZQUEZ-MELLADO, Janitzia; COLLANTES-ESTEVEZ, EduardoThe aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA). This observational cross-section study included 1264 consecutive SpA patients who fulfilled the modified New York criteria for ankylosing spondylitis (AS). Demographic, clinical, and radiologic data were evaluated. Categorical data were compared by chi(2) or Fisher's exact tests and continuous variables by ANOVA with post-hoc tests. Primary AS was diagnosed in 1072 patients, psoriatic spondylitis in 147, and spondylitis associated to inflammatory bowel disease (IBD) in 45 patients. Overall, male patients were significantly younger, had longer diagnostic delay, lower disease activity, worse spinal mobility, better quality of life, and more severe radiologic damage. Dactylitis and enthesitis, as well as swollen joint count, were significantly more common among women. In primary AS, there was a marked male predominance (76.2%). Among patients with psoriatic spondylitis, male predominance was lower (57.8%), but was also associated with worse spinal mobility and more severe radiologic damage. In the total population, male patients with primary AS referred higher permanent work disability (13.2% vs 6.9%; P<0.05), although no difference was observed in psoriatic or IBD spondylitis according to the gender. Among Ibero-American SpA patients, there are some differences in clinical and radiological manifestations, men showing more structural damage, whereas women more active disease. These data suggest that the phenotype of SpA differs between genders. This can influence the subsequent diagnostic approach and therapeutic decisions.
- Development of ASAS quality standards to improve the quality of health and care services for patients with axial spondyloarthritis(2020) KILTZ, Uta; LANDEWE, Robert B. M.; HEIJDE, Desiree van der; RUDWALEIT, Martin; WEISMAN, Michael H.; AKKOC, Nurullah; BOONEN, Annelies; BRANDT, Jan; CARRON, Philippe; DOUGADOS, Maxime; GOSSEC, Laure; JONGKEES, Merryn; MACHADO, Pedro M.; MARZO-ORTEGA, Helena; MOLTO, Anna; NAVARRO-COMPAN, Victoria; NIEDERMAN, Karin; SAMPAIO-BARROS, Percival Degrava; SLOBODIN, Gleb; BOSCH, Filip E. van den; TUBERGEN, Astrid van; WEELY, Salima van; WIEK, Dieter; BRAUN, JuergenObjectives The Assessment of SpondyloArthritis International Society (ASAS) aimed to develop a set of quality standards (QS) to help improve the quality of healthcare provided to adult patients affected by axial spondyloarthritis (axSpA) worldwide. Methods An ASAS task force developed a set of QS using a stepwise approach. First, key areas for quality improvement were identified, discussed, rated and agreed on. Thereafter, areas were prioritised and statements for the most important key areas were phrased on consensus. Appropriate quality measures were defined to allow quantification of the QS at the community level. Results The ASAS task force, consisting of 20 rheumatologists, two physiotherapists and two patients, selected and proposed 34 potential key areas for quality improvement which were then commented by 140 ASAS members and patients. Within that process three new key areas came up, which led to a re-evaluation of all 37 key areas by 120 ASAS members and patients. Five key areas were identified as most important to determine quality of care: referral including rapid access, rheumatology assessment, treatment, education/self-management and comorbidities. Finally, nine QS were agreed on and endorsed by the whole ASAS membership. Conclusions ASAS successfully developed the first set of QS to help improving healthcare for adult patients with axSpA. Even though it may currently not be realistic to achieve the QS in all healthcare systems, they provide high-quality of care framework for patients with axSpA that should be aimed for.
- Comparison of the Clinical Expression of Patients with Ankylosing Spondylitis from Europe and Latin America(2012) BENEGAS, Mariana; MUNOZ-GOMARIZ, Elisa; FONT, Pilar; BURGOS-VARGAS, Ruben; CHAVES, Jose; PALLEIRO, Daniel; COCCO, Jose Maldonado; GUTIERREZ, Miguel; SAENZ, Ricardo; STECKMEN, Ivan; RILLO, Oscar; MULERO, Juan; SAMPAIO-BARROS, Percival; BARCELOS, Anabela; CRUYSSEN, Bert Vander; VAZQUEZ-MELLADO, Janitzia; ESTEVEZ, Eduardo CollantesObjective. To compare the clinical, demographic, and serologic characteristics and the treatment of patients diagnosed with ankylosing spondylitis (AS) from Europe (EU) and Latin America (LA). Methods. We included 3439 patients from national registries: the Spanish Registry of Spondyloarthritis (REGISPONSER), the Belgian registry (ASPECT), and the Latin American Registry of Spondyloarthropathies (RESPONDIA). We selected patients with diagnosis of AS who met the modified New York classification criteria. Demographic, clinical, disease activity, functional, and metrological measurement data were recorded. Current treatment was recorded. The population was classified into 2 groups: patients with disease duration < 10 years and those with disease duration >= 10 years. A descriptive and comparative analysis of variables of both groups was carried out. Results. There were 2356 patients in EU group and 1083 in LA group. Prevalence of HLA-B27 was 71% in LA group and 83% in EU group (p < 0.001). We found a greater frequency of peripheral arthritis and enthesitis (p < 0.001) in the LA population; prevalence of arthritis was 57% in LA and 42% in EU, and for enthesitis, 54% and 38%. Except for treatment with anti-tumor necrosis factor (anti-TNF), the use of nonsteroidal antiinflammatory drugs (NSAID), corticosteroids, and disease-modifying antirheumatic drugs (DMARD), and the association of anti-TNF and methotrexate use showed a significant difference (p < 0.001) in the 2 populations. Conclusion. The principal differences in the clinical manifestations of patients with AS from EU and LA were the greater frequency of peripheral arthritis and enthesitis in LA group, the higher percentage of HLA-B27 in EU group, and the form of treatment, with a greater use of NSAID, steroids, and DMARD in the LA group.
- Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis(2019) SOBANSKI, Vincent; GIOVANNELLI, Jonathan; ALLANORE, Yannick; RIEMEKASTEN, Gabriela; AIRO, Paolo; VETTORI, Serena; COZZI, Franco; DISTLER, Oliver; MATUCCI-CERINIC, Marco; DENTON, Christopher; LAUNAY, David; HACHULLA, Eric; CERINIC, Marco Matucci; GUIDUCCI, Serena; WALKER, Ulrich; KYBURZ, Diego; LAPADULA, Giovanni; IANNONE, Florenzo; DISTLER, Oliver; MAURER, Britta; JORDAN, Suzana; BECVAR, Radim; SIERAKOWSKY, Stanislaw; BIELECKA, Otylia Kowal; CUTOLO, Maurizio; SULLI, Alberto; VALENTINI, Gabriele; CUOMO, Giovanna; VETTORI, Serena; SIEGERT, Elise; REDNIC, Simona; NICOARA, Ileana; KAHAN, Andre; ALLANORE, Yannick; VLACHOYIANNOPOULOS, Panayiotis; MONTECUCCO, Carlo; CAPORALI, Roberto; STORK, Jiri; INANC, Murat; CARREIRA, Patricia E.; NOVAK, Srdan; CZIRJAK, Laszlo; VARJU, Cecilia; CHIZZOLINI, Carlo; KUCHARZ, Eugene J.; KOTULSKA, Anna; KOPEC-MEDREK, Magdalena; WIDUCHOWSKA, Malgorzata; COZZI, Franco; ROZMAN, Blaz; MALLIA, Carmel; COLEIRO, Bernard; GABRIELLI, Armando; FARGE, Dominique; WU, Chen; MARJANOVIC, Zora; FAIVRE, Helene; HIJ, Darin; DHAMADI, Roza; AIRO, Paolo; HESSELSTRAND, Roger; WOLLHEIM, Frank; WUTTGE, Dirk M.; ANDREASSON, Kristofer; MARTINOVIC, Duska; BALBIR-GURMAN, Alexandra; BRAUN-MOSCOVICI, Yolanda; TROTTA, Francesco; MONACO, Andrea Lo; HUNZELMANN, Nicolas; PELLERITO, Raffaele; BAMBARA, Lisa Maria; CARAMASCHI, Paola; MOROVIC-VERGLES, Jadranka; BLACK, Carol; DENTON, Christopher; DAMJANOV, Nemanja; HENES, Joerg; SANTAMARIA, Vera Ortiz; HEITMANN, Stefan; KRASOWSKA, Dorota; SEIDEL, Matthias; HASLER, Paul; BURKHARDT, Harald; HIMSEL, Andrea; BAJOCCHI, Gianluigi; NUOVA, Arcispedale Santa Maria; SALVADOR, Maria Joao; SILVA, Jose Antonio Pereira Da; STAMENKOVIC, Bojana; STANKOVIC, Aleksandra; SELMI, Carlo Francesco; SANTIS, Maria De; MARASINI, Bianca; TIKLY, Mohammed; ANANIEVA, Lidia P.; DENISOV, Lev N.; MUELLER-LADNER, Ulf; FRERIX, Marc; TARNER, Ingo; SCORZA, Raffaella; PUPPO, Francesco; ENGELHART, Merete; STRAUSS, Gitte; NIELSEN, Henrik; DAMGAARD, Kirsten; SZUCS, Gabriella; SZAMOSI, Szilvia; MENDOZA, Antonio Zea; PUENTE, Carlos de la; GIRALDO, Walter Alberto Sifuentes; MIDTVEDT, Oyvind; REISETER, Silje; GAREN, Torhild; HACHULLA, Eric; LAUNAY, David; VALESINI, Guido; RICCIERI, Valeria; IONESCU, Ruxandra Maria; OPRIS, Daniela; GROSEANU, Laura; WIGLEY, Fredrick M.; CORNATEANU, Roxana Sfrent; IONITESCU, Razvan; GHERGHE, Ana Maria; SOARE, Alina; GORGA, Marilena; BOJINCA, Mihai; MIHAI, Carina; MILICESCU, Mihaela; SUNDERKOETTER, Cord; KUHN, Annegret; SANDORFI, Nora; SCHETT, Georg; DISTLER, Joerg H. W.; BEYER, Christian; MERONI, Pierluigi; INGEGNOLI, Francesca; MOUTHON, Luc; KEYSER, Filip De; SMITH, Vanessa; CANTATORE, Francesco Paolo; CORRADO, Ada; ULLMAN, Susanne; IVERSEN, Line; MUEHLEN, Carlos Alberto von; BOHN, Jussara Marilu; LONZETTI, Lilian Scussel; POZZI, Maria Rosa; EYERICH, Kilian; HEIN, Ruediger; KNOTT, Elisabeth; WILAND, Piotr; SZMYRKA-KACZMAREK, Magdalena; SOKOLIK, Renata; MORGIEL, Ewa; MADEJ, Marta; HOUSSIAU, Frederic A.; ALEGRE-SANCHO, Juan Jose; KRUMMEL-LORENZ, Brigitte; SAAR, Petra; ARINGER, Martin; GUENTHER, Claudia; WESTHOVENS, Rene; LANGHE, Ellen de; LENAERTS, Jan; ANIC, Branimir; BARESIC, Marko; MAYER, Miroslav; UPRUS, Maria; OTSA, Kati; YAVUZ, Sule; GRANEL, Brigitte; RADOMINSKI, Sebastiao Cezar; MUELLER, Carolina de Souza; AZEVEDO, Valderilio Feijo; JIMENEZ, Sergio; BUSQUETS, Joanna; AGACHI, Svetlana; GROPPA, Liliana; CHIABURU, Lealea; RUSSU, Eugen; POPA, Sergei; ZENONE, Thierry; PILECKYTE, Margarita; STEBBINGS, Simon; HIGHTON, John; MATHIEU, Alessandro; VACCA, Alessandra; SAMPAIO-BARROS, Percival D.; YOSHINARI, Natalino H.; MARANGONI, Roberta G.; MARTIN, Patricia; FUOCCO, Luiza; STAMP, Lisa; CHAPMAN, Peter; O'DONNELL, John; SOLANKI, Kamal; DOUBE, Alan; VEALE, Douglas; O'ROURKE, Marie; LOYO, Esthela; LI, Mengtao; MOHAMED, Walid Ahmed Abdel Atty; ROSATO, Edoardo; AMOROSO, Antonio; GIGANTE, Antonietta; OKSEL, Fahrettin; YARGUCU, Figen; TANASEANU, Cristina-Mihaela; POPESCU, Monica; DUMITRASCU, Alina; TIGLEA, Isabela; FOTI, Rosario; CHIRIEAC, Rodica; ANCUTA, Codrina; FURST, Daniel E.; VILLIGER, Peter; ADLER, Sabine; LAAR, Jacob van; KAYSER, Cristiane; EDUARDO, Andrade Luis C.; FATHI, Nihal; HASSANIEN, Manal; LEFEBVRE, Paloma Garcia de la Pena; RUBIO, Silvia Rodriguez; EXPOSITO, Marta Valero; SIBILIA, Jean; CHATELUS, Emmanuel; GOTTENBERG, Jacques Eric; CHIFFLOT, Helene; LITINSKY, Ira; EMERY, Paul; BUCH, Maya; GALDO, Francesco Del; VENALIS, Algirdas; BUTRIMIENE, Irena; VENALIS, Paulius; RUGIENE, Rita; KARPEC, Diana; SAKETKOO, Lesley Ann; LASKY, Joseph A.; KERZBERG, Eduardo; MONTOYA, Fabiana; COSENTINO, Vanesa; LIMONTA, Massimiliano; BRUCATO, Antonio Luca; LUPI, Elide; ROSNER, Itzhak; ROZENBAUM, Michael; SLOBODIN, Gleb; BOULMAN, Nina; RIMAR, Doron; COUTO, Maura; SPERTINI, Francois; RIBI, Camillo; BUSS, Guillaume; KAHL, Sarah; HSU, Vivien M.; CHEN, Fei; MCCLOSKEY, Deborah; MALVEAUX, Halina; PASQUALI, Jean Louis; MARTIN, Thierry; GORSE, Audrey; GUFFROY, Aurelien; POINDRON, VincentObjective Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that is typically subdivided into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) depending on the extent of skin involvement. This subclassification may not capture the entire variability of clinical phenotypes. The European Scleroderma Trials and Research (EUSTAR) database includes data on a prospective cohort of SSc patients from 122 European referral centers. This study was undertaken to perform a cluster analysis of EUSTAR data to distinguish and characterize homogeneous phenotypes without any a priori assumptions, and to examine survival among the clusters obtained. Methods A total of 11,318 patients were registered in the EUSTAR database, and 6,927 were included in the study. Twenty-four clinical and serologic variables were used for clustering. Results Clustering analyses provided a first delineation of 2 clusters showing moderate stability. In an exploratory attempt, we further characterized 6 homogeneous groups that differed with regard to their clinical features, autoantibody profile, and mortality. Some groups resembled usual dcSSc or lcSSc prototypes, but others exhibited unique features, such as a majority of lcSSc patients with a high rate of visceral damage and antitopoisomerase antibodies. Prognosis varied among groups and the presence of organ damage markedly impacted survival regardless of cutaneous involvement. Conclusion Our findings suggest that restricting subsets of SSc patients to only those based on cutaneous involvement may not capture the complete heterogeneity of the disease. Organ damage and antibody profile should be taken into consideration when individuating homogeneous groups of patients with a distinct prognosis.
- Gender Differences Among Spondylitis Associated with Psoriasis, Inflammatory Bowel Disease and Primary Ankylosing Spondylitis(2012) LANDI, Margarita; MALDONADO-FICCO, Hernan; MALDONADO-COCCO, Jose A.; CITERA, Gustavo; ARTURI, Pablo; SAMPAIO-BARROS, Percival; FLORES, Diana; BURGOS-VARGAS, Ruben; SANTOS, Helena; CHAVEZ-CORRALES, Jose; PALLEIRO, Daniel; GUTIERREZ, Miguel A.; VIEIRA-SOUSA, Elsa; PIMENTEL-SANTOS, Fernando; PAIRA, Sergio O.; SR., Alberto Berman; VAZQUEZ-MELLADO, Janitzia; COLLANTES-ESTEVEZ, Edu-ArdoBackground/Purpose: Differences regarding gender in primary Anky-losing Spondylitis are well known. However, there is less evidence regarding Spondylitis Associated with Psoriasis and that associated with Inflammatory Bowel Disease. To compare clinical manifestations, disease activity, functional capacity, spinal mobility and radiological findings among women and men from a multicenter, multiethnic cohort, of Ibero-American patients with Spondyloarthritis. Methods: This observational cross-section study included 2044 consecutive spondyloarthritis (SpA) patients (ESSG criteria). Demographic, clinical, disease activity, functional ability, quality of life, work status and radiologic data were evaluated and collected by RESPONDIA members from different Ibero-American countries between June and December 2006. For this analysis patients were selected only if they met modified New York criteria for AS. Data was transmitted on-line and stored in the Spanish SpA Registry (REGISPONSER) website. Categorial data were compared by X2 or Fisher’s exact tests and continuous variables by ANOVA with post-hoc tests. Results: Out of 2044 patients, 1264 met New York criteria; 73% were male, (mean age 43 years, SD 15.8), and 27% were female (mean age 45,8 years, SD = 12.6). 1072 had primary Ankylosing Spondylitis (AS), 147 Spondylitis Associated to Psoriasis (PsSp) and 45 Spondilytis associated to Inflammatory Bowel Disease (IBDSp). Overall, male patients were significantly younger, had longer diagnostic delay, lower disease activity (BASDAI), less swollen joints, worse spinal mobility (BASMI), better quality of life although worse total BASRI. Frequency of dactylitis and enthesitis was significantly more common among women. Analysing only AS, there was marked male predominance (76.2%). Male patients were also significantly younger, had lower disease activity, worse BASMI, better quality of life and less frequency of dactylitis, yet worse total BASRI. When reading only BASRI in the spine, still it was significantly higher in male patients (mean 7.3 vs 5.8 p = 0.000). However, among patients with PsSp male predominance was lower (57.8%), had significantly worse total BASRI and spinal BASRI and worse spinal mobility (BASMI). Among the 45 patients with IBDSp there was a slight female predominance (51.1%) and only differed in less lateral lumbar flexion in males (p = 0.015). Regarding work disability in the total population, men had higher permanent work disability (13.2 vs. 6.9 p < 0.05). These differences were maintained when subdividing patients according to primary AS but were no differences in PsSp. There were no patient with IBDSp and permanent work disability. Conclusion: In this gender comparative analysis among Psoriatic, IBD and primary AS, male patients were significantly younger, had longer diagnostic delay, worse total BASRI, higher BASMI, strikingly lower disease activity (BASDAI) and better quality of life. In both primary AS and PsSp groups, women had better spinal mobility and less radiographic damage.
- EFFICACY OF UPADACITINIB IN PATIENTS WITH NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS IN EARLY VERSUS ESTABLISHED DISEASE(2023) NAVARRO-COMPAN, V.; BOSCH, F. Van den; SAMPAIO-BARROS, P. D.; GANZ, F.; BILJAN, A.; DUAN, Y.; D'SILVA, K.; WUNG, P.; OSTOR, A.; RAMIRO, S.
- Perfil epidemiológico da espondiloartrite de início juvenil comparada com a espondiloartrite de início na vida adulta em uma grande coorte brasileira(2014) DUARTE, Angela P.; MARQUES, Claudia D. L.; BORTOLUZZO, Adriana B.; GONCALVES, Celio R.; SILVA, Jose Antonio Braga da; XIMENES, Antonio Carlos; BERTOLO, Manoel B.; RIBEIRO, Sandra Lucia E.; KEISERMAN, Mauro; SKARE, Thelma L.; CARNEIRO, Sueli; MENIN, Rita; AZEVEDO, Valderilio F.; VIEIRA, Walber P.; ALBUQUERQUE, Elisa N.; BIANCHI, Washington A.; BONFIGLIOLI, Rubens; CAMPANHOLO, Cristiano; CARVALHO, Hellen M. S.; COSTA, Izaias P.; KOHEM, Charles L.; LEITE, Nocy; LIMA, Sonia A. L.; MEIRELLES, Eduardo S.; PEREIRA, Ivanio A.; PINHEIRO, Marcelo M.; POLITO, Elizandra; RESENDE, Gustavo G.; ROCHA, Francisco Airton C.; SANTIAGO, Mittermayer B.; SAUMA, Maria de Fatima L. C.; VALIM, Valeria; BARROS, Percival D. SampaioObjective: To analyze the clinical and epidemiologic characteristics ofjuvenile-onset spondyloarthritis (SpA) (<16 years) and compare them with a group of adult-onset (> 16 years) SpA patients. Patients and methods: Prospective, observational and multicentric cohort with 1,424 patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group (ESSG) submitted to a common protocol of investigation and recruited in 29 reference centers participants of the Brazilian Registry of Spondyloarthritis (RBE - Registro Brasileiro de Espondiloartrites). Patients were divided in two groups: age at onset < 16 years (JOSpA group) and age at onset 16 years (A0SpA group). Results: Among the 1,424 patients, 235 presented disease onset before 16 years (16.5%). The clinical and epidemiologic variables associated with JOSpA were male gender (p <0.001), lower limb arthritis (p = 0.001), enthesitis (p = 0.008), anterior uveitis (p = 0.041) and positive HLA-B27 (p = 0.017), associated with lower scores of disease activity (Bath Ankylosing Spondylitis Disease Activity Index - BASDAI; p = 0.007) and functionality (Bath Ankylosing Spondylitis Functional Index - BASFI; p = 0.036). Cutaneous psoriasis (p <0.001), inflammatory bowel disease (p = 0.023), dactylitis (p = 0.024) and nail involvement (p = 0.004) were more frequent in patients with adult-onset SpA. Conclusions: Patients with JOSpA in this large Brazilian cohort were characterized predominantly by male gender, peripheral involvement (arthritis and enthesitis), positive HLA-B27 and lower disease scores.
article 31 Citação(ões) na Scopus An analysis of 372 patients with anterior uveitis in a large Ibero-American cohort of spondyloarthritis: the RESPONDIA Group(2013) SAMPAIO-BARROS, P. D.; PEREIRA, I. A.; HERNANDEZ-CUEVAS, C.; BERMAN, A.; BURGOS-VARGAS, R.; GUTIERREZ, M. A.; BAREELOS, A.; CHAVEZ-CORRALES, J. E.; MORENO, M.; PALLEIRO, D. R.; SAENZ-CASTRO, R.; STEKMAN, I.; AZEVEDO, V. F.; BRAGA-DA-SILVA, J. A.; CITERA, G.; FLORES-ALVARADO, D.; GONCAIVES, C. R.; GRAF, C.; NITSCHE, A.; SAAVEDRA, J.; XIMENES, A. C.; VAZQUEZ-MELLADO, J.; COLLANTES-ESTEVEZ, E.Objectives This study analysed the frequency of anterior uveitis (AU) and its correlations in a large cohort of patients with spondyloarthritis (SpA). Methods A common protocol of investigation was prospectively applied to 2012 SpA patients in 85 centres from 10 Ibero-American countries. Clinical and demographic variables and disease indexes were investigated. Categorical variables were compared by chi(2) and Fisher's exact test, and continuous variables were compared by ANOVA or Kruskal-Wallis test. A value of p<0.05 was considered significant. Results AU was referred by 372 SpA patients (18.5%). AU was statistically associated with inflammatory low back pain (p<0.001), radiographic sacroiliitis (p<0.001), enthesopathies (p=0.004), urethritis/acute diarrhoea (p<0.001), balanitis (p=0.002), hip involvement (p=0.002), HLA-B27 (p=0.003), and higher C-reactive protein (p=0.001), whilst it was negatively associated with the number of painful (p=0.03) and swollen (p=0.005) peripheral joints, psoriatic arthritis (p<0.001), psoriasis (p<0.001), nail involvement (p<0.001), and dactilitis (p=0.062; trend). No association with gender, race, and indices (disease activity, functionality and quality of life) was observed. Logistic regression showed that ankylosing spondylitis (p=0.001) and HLA-B27 (p=0.083; trend) was significantly associated with AU, while extra-articular manifestations (predominantly psoriasis) were negatively associated (p=0.016). Conclusion Anterior uveitis is a frequent extra-articular manifestation in SpA patients, positively associated with axial involvement and HLA-B27 and negatively associated with peripheral involvement and psoriatic arthritis.conferenceObject Development of a Set of ASAS Quality Standards for Adults with Axial Spondyloarthritis(2019) KILTZ, Uta; LANDEWE, Robert B. M.; HEIJDE, Desiree van der; RUDWALEIT, Martin; WEISMAN, Michael; AKKOC, Nurullah; BOONEN, Annelies; BRANDT-JUERGENS, Jan; CARRON, Philippe; DOUGADOS, Maxime; GOSSEC, Laure; JONGKEES, Merryn; MACHADO, Pedro; MARZO-ORTEGA, Helena; MOLTO, Anna; NAVARRO-COMPAN, Victoria; NIEDERMANN-SCHNEIDER, Karin; SAMPAIO-BARROS, Percival Degrava; SLOBODIN, Gleb; BOSCH, Filip Van den; TUBERGEN, Astrid van; WEELY, Salima van; WIEK, Dieter; BRAUN, Jurgen- Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study(2019) ELHAI, Muriel; BOUBAYA, Marouane; DISTLER, Oliver; SMITH, Vanessa; MATUCCI-CERINIC, Marco; SANCHO, Juan Jose Alegre; TRUCHETET, Marie-Elise; BRAUN-MOSCOVICI, Yolanda; IANNONE, Florenzo; NOVIKOV, Pavel I.; LESCOAT, Alain; SIEGERT, Elise; CASTELLVI, Ivan; AIRO, Paolo; VETTORI, Serena; LANGHE, Ellen De; HACHULLA, Eric; ERLER, Anne; ANANIEVA, Lidia; KRUSCHE, Martin; LOPEZ-LONGO, F. J.; DISTLER, Joerg H. W.; HUNZELMANN, Nicolas; HOFFMANN-VOLD, Anna-Maria; RICCIERI, Valeria; HSU, Vivien M.; POZZI, Maria R.; ANCUTA, Codrina; ROSATO, Edoardo; MIHAI, Carina; KUWANA, Masataka; SAKETKOO, Lesley Ann; CHIZZOLINI, Carlo; HESSELSTRAND, Roger; ULLMAN, Susanne; YAVUZ, Sule; REDNIC, Simona; CAIMMI, Cristian; BLOCH-QUEYRAT, Coralie; ALLANORE, Yannick; GUIDUCCI, Serena; WALKER, Ulrich A.; KYBURZ, Diego; LAPADULA, Giovanni; MAURER, Britta; JORDAN, Suzana; DOBROTA, Rucsandra; BECVAR, Radim; SIERAKOWSKY, Stanislaw; BIELECKA, Otylia Kowal; SULLI, Alberto; CUTOLO, Maurizio; CUOMO, Giovanna; NICOARA, Ileana; KAHAN, Andre; VLACHOYIANNOPOULOS, Panayiotis G.; MONTECUCCO, Carlo Maurizio; CAPORALI, Roberto; STORK, Jiri; INANC, Murat; CARREIRA, Patricia E.; NOVAK, Srdan; CZIRJAK, Laszlo; VARJU, Cecilia; KUCHARZ, Eugene J.; KOTULSKA, Anna; KOPEC-MEDREK, Magdalena; WIDUCHOWSKA, Malgorzata; COZZI, Franco; ROZMAN, Blaz; MALLIA, Carmel; COLEIRO, Bernard; GABRIELLI, Armando; FARGE, Dominique; WU, Chen; MARJANOVIC, Zora; FAIVRE, Helene; HIJ, Darin; DHAMADI, Roza; WOLLHEIM, Frank; SCHEJA, Agneta; WUTTGE, Dirk M.; ANDREASSON, Kristofer; MARTINOVIC, Duska; BALBIR-GURMAN, Alexandra; TROTTA, F.; MONACO, Andrea Lo; PELLERITO, Raffaele; MAURIZIANO, Ospedale; CARAMASCHI, Paola; MOROVIC-VERGLES, Jadranka; BLACK, Carol; DENTON, Christopher; DAMJANOV, Nemanja; HENES, Jorg; SANTAMARIA, Vera Ortiz; HEITMANN, Stefan; KRASOWSKA, Dorota; Matthias; HASLER, Paul; BURKHARDT, Harald; HIMSEL, Andrea; BAJOCCHI, Gianluigi; SILVA, Jose Antonio Pereira Da; SALVADOR, Maria Joao; STAMENKOVIC, Bojana; STANKOVIC, Aleksandra; SELMI, Carlo Francesco; SANTIS, Maria De; TIKLY, Mohammed; DENISOV, Lev N.; HERRICK, Ariane; MUELLER-LADNER, Ulf; FRERIX, Marc; TARNER, Ingo; SCORZA, Raffaella; PUPPO, Francesco; ENGELHART, Merete; STRAUSS, Gitte; NIELSEN, Henrik; DAMGAARD, Kirsten; SZUCS, Gabriela; MENDOZA, Antonio Zea; PUENTE, Carlos de la; GIRALDO, Sifuentes W. A.; MIDTVEDT, Oyvind; REISETER, Silje; GAREN, Torhild; LAUNAY, David; VALESINI, Guido; IONESCU, Ruxandra Maria; GROSEANU, Laura; OPRIS, Daniela; CORNATEANU, Roxana Sfrent; IONITESCU, Razvan; GHERGHE, Ana Maria; SOARE, Alina; GORGA, Marilena; BOJINCA, Mihai; MILICESCU, Mihaela; SUNDERKOTTER, Cord; KUHN, Annegret; SANDORFI, Nora; SCHETT, Georg; BEYER, Christian; MERONI, Pierluigi; INGEGNOLI, Francesca; MOUTHON, Luc; KEYSER, Filip De; MELSENS, Karin; CANTATORE, Francesco P.; CORRADO, Ada; IVERSEN, Line; MUHLEN, Carlos Alberto von; BOHN, Jussara Marilu; LONZETTI, Lilian Scussel; EYERICH, Kilian; HEIN, Rudiger; KNOTT, Elisabeth; WILAND, Piotr; SZMYRKA-KACZMAREK, Magdalena; SOKOLIK, Renata; MORGIEL, Ewa; MADEJ, Marta; HOUSSIAU, Frederic A.; KRUMMEL-LORENZ, Brigitte; SAAR, Petra; ARINGER, Martin; GUNTHER, Claudia; WESTHOVENS, Rene; LENAERTS, Jan; ANIC, Branimir; BARESIC, Marko; MAYER, Miroslav; UPRUS, Maria; OTSA, Kati; GRANEL, Brigitte; MULLER, Carolina de Souza; RADOMINSKI, Sebastiao C.; AZEVEDO, Valderilio F.; JIMENEZ, Sergio; BUSQUETS, Joanna; AGACHI, Svetlana; GROPPA, Liliana; CHIABURU, Lealea; RUSSU, Eugen; POPA, Sergei; ZENONE, Thierry; PILECKYTE, Margarita; MATHIEU, Alessandro; VACCA, Alessandra; SAMPAIO-BARROS, Percival D.; YOSHINARI, Natalino H.; MARANGONI, Roberta G.; MARTIN, Patricia; FUOCCO, Luiza; STEBBINGS, Simon; HIGHTON, John; CHAPMAN, Peter; O'DONNELL, John; STAMP, Lisa; DOUBE, Alan; SOLANKI, Kamal; VEALE, Douglas; O'ROURKE, Marie; LOYO, Esthela; LI, Mengtao; MOHAMED, Walid Ahmed Abdel Atty; AMOROSO, Antonio; GIGANTE, Antonietta; OKSEL, Fahrettin; YARGUCU, Figen; TANASEANU, Cristina-Mihaela; POPESCU, Monica; DUMITRASCU, Alina; TIGLEA, Isabela; FOTI, Rosario; CHIRIEAC, Rodica; FURST, Daniel; VILLIGER, Peter; ADLER, Sabine; LAAR, Jacob van; KAYSER, Cristiane; FATHI, Nihal; HASSANIEN, Manal; LEFEBVRE, Paloma Garcia de la Pena; RUBIO, Silvia Rodriguez; EXPOSITO, Marta Valero; CHATELUS, Emmanuel; SIBILIA, Jean; GOTTENBERG, Jacques Eric; CHIFFLOT, Helene; LITINSKY, Ira; EMERY, Paul; BUCH, Maya; GALDO, Francesco Del; VENALIS, Algirdas; BUTRIMIENE, Irena; VENALIS, Paulius; RUGIENE, Rita; KARPEC, Diana; LASKY, Joseph A.; COSENTINO, Vanesa; KERZBERG, Eduardo; MONTOYA, Fabiana; BIANCHI, Washington; CARNEIRO, Sueli; MARETTI, Giselle Baptista; BIANCHI, Dante Valdetaro; LIMONTA, Massimiliano; BRUCATO, Antonio Luca; LUPI, Elide; ROSNER, Itzhak; ROZENBAUM, Michael; SLOBODIN, Gleb; BOULMAN, Nina; RIMAR, Doron; COUTO, Maura; KAHL, Sarah; CHEN, Fei; MCCLOSKEY, Deborah; MALVEAUX, Halina; SPERTINI, Francois; RIBI, Camillo; BUSS, Guillaume; MARTIN, Thierry; GUFFROY, Aurelien; POINDRON, Vincent; CHOTCHAEVA, Fatima; MUKHIN, Nikolay A.; MOISEEV, SergeyObjective To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice. Methods We performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibrosis worsening and steroids use among propensity score-matched patients treated or not with rituximab. Results 254 patients were treated with rituximab, in 58% for lung and in 32% for skin involvement. After a median follow-up of 2 years, about 70% of the patients had no side effect. Comparison of treated patients with 9575 propensity-score matched patients showed that patients treated with rituximab were more likely to have skin fibrosis improvement (22.7 vs 14.03 events per 100 person-years; OR: 2.79 [1.47-5.32]; p=0.002). Treated patients did not have significantly different rates of decrease in forced vital capacity (FVC)>10% (OR: 1.03 [0.55-1.94]; p=0.93) nor in carbon monoxide diffusing capacity (DLCO) decrease. Patients having received rituximab were more prone to stop or decrease steroids (OR: 2.34 [1.56-3.53], p<0.0001). Patients treated concomitantly with mycophenolate mofetil had a trend for better outcomes as compared with patients receiving rituximab alone (delta FVC: 5.22 [0.83-9.62]; p=0.019 as compared with controls vs 3 [0.66-5.35]; p=0.012). Conclusion Rituximab use was associated with a good safety profile in this large SSc-cohort. Significant change was observed on skin fibrosis, but not on lung. However, the limitation is the observational design. The potential stabilisation of lung fibrosis by rituximab has to be addressed by a randomised trial.