PERCIVAL DEGRAVA SAMPAIO BARROS

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Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina

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  • article 75 Citação(ões) na Scopus
    Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis
    (2019) SOBANSKI, Vincent; GIOVANNELLI, Jonathan; ALLANORE, Yannick; RIEMEKASTEN, Gabriela; AIRO, Paolo; VETTORI, Serena; COZZI, Franco; DISTLER, Oliver; MATUCCI-CERINIC, Marco; DENTON, Christopher; LAUNAY, David; HACHULLA, Eric; CERINIC, Marco Matucci; GUIDUCCI, Serena; WALKER, Ulrich; KYBURZ, Diego; LAPADULA, Giovanni; IANNONE, Florenzo; DISTLER, Oliver; MAURER, Britta; JORDAN, Suzana; BECVAR, Radim; SIERAKOWSKY, Stanislaw; BIELECKA, Otylia Kowal; CUTOLO, Maurizio; SULLI, Alberto; VALENTINI, Gabriele; CUOMO, Giovanna; VETTORI, Serena; SIEGERT, Elise; REDNIC, Simona; NICOARA, Ileana; KAHAN, Andre; ALLANORE, Yannick; VLACHOYIANNOPOULOS, Panayiotis; MONTECUCCO, Carlo; CAPORALI, Roberto; STORK, Jiri; INANC, Murat; CARREIRA, Patricia E.; NOVAK, Srdan; CZIRJAK, Laszlo; VARJU, Cecilia; CHIZZOLINI, Carlo; KUCHARZ, Eugene J.; KOTULSKA, Anna; KOPEC-MEDREK, Magdalena; WIDUCHOWSKA, Malgorzata; COZZI, Franco; ROZMAN, Blaz; MALLIA, Carmel; COLEIRO, Bernard; GABRIELLI, Armando; FARGE, Dominique; WU, Chen; MARJANOVIC, Zora; FAIVRE, Helene; HIJ, Darin; DHAMADI, Roza; AIRO, Paolo; HESSELSTRAND, Roger; WOLLHEIM, Frank; WUTTGE, Dirk M.; ANDREASSON, Kristofer; MARTINOVIC, Duska; BALBIR-GURMAN, Alexandra; BRAUN-MOSCOVICI, Yolanda; TROTTA, Francesco; MONACO, Andrea Lo; HUNZELMANN, Nicolas; PELLERITO, Raffaele; BAMBARA, Lisa Maria; CARAMASCHI, Paola; MOROVIC-VERGLES, Jadranka; BLACK, Carol; DENTON, Christopher; DAMJANOV, Nemanja; HENES, Joerg; SANTAMARIA, Vera Ortiz; HEITMANN, Stefan; KRASOWSKA, Dorota; SEIDEL, Matthias; HASLER, Paul; BURKHARDT, Harald; HIMSEL, Andrea; BAJOCCHI, Gianluigi; NUOVA, Arcispedale Santa Maria; SALVADOR, Maria Joao; SILVA, Jose Antonio Pereira Da; STAMENKOVIC, Bojana; STANKOVIC, Aleksandra; SELMI, Carlo Francesco; SANTIS, Maria De; MARASINI, Bianca; TIKLY, Mohammed; ANANIEVA, Lidia P.; DENISOV, Lev N.; MUELLER-LADNER, Ulf; FRERIX, Marc; TARNER, Ingo; SCORZA, Raffaella; PUPPO, Francesco; ENGELHART, Merete; STRAUSS, Gitte; NIELSEN, Henrik; DAMGAARD, Kirsten; SZUCS, Gabriella; SZAMOSI, Szilvia; MENDOZA, Antonio Zea; PUENTE, Carlos de la; GIRALDO, Walter Alberto Sifuentes; MIDTVEDT, Oyvind; REISETER, Silje; GAREN, Torhild; HACHULLA, Eric; LAUNAY, David; VALESINI, Guido; RICCIERI, Valeria; IONESCU, Ruxandra Maria; OPRIS, Daniela; GROSEANU, Laura; WIGLEY, Fredrick M.; CORNATEANU, Roxana Sfrent; IONITESCU, Razvan; GHERGHE, Ana Maria; SOARE, Alina; GORGA, Marilena; BOJINCA, Mihai; MIHAI, Carina; MILICESCU, Mihaela; SUNDERKOETTER, Cord; KUHN, Annegret; SANDORFI, Nora; SCHETT, Georg; DISTLER, Joerg H. W.; BEYER, Christian; MERONI, Pierluigi; INGEGNOLI, Francesca; MOUTHON, Luc; KEYSER, Filip De; SMITH, Vanessa; CANTATORE, Francesco Paolo; CORRADO, Ada; ULLMAN, Susanne; IVERSEN, Line; MUEHLEN, Carlos Alberto von; BOHN, Jussara Marilu; LONZETTI, Lilian Scussel; POZZI, Maria Rosa; EYERICH, Kilian; HEIN, Ruediger; KNOTT, Elisabeth; WILAND, Piotr; SZMYRKA-KACZMAREK, Magdalena; SOKOLIK, Renata; MORGIEL, Ewa; MADEJ, Marta; HOUSSIAU, Frederic A.; ALEGRE-SANCHO, Juan Jose; KRUMMEL-LORENZ, Brigitte; SAAR, Petra; ARINGER, Martin; GUENTHER, Claudia; WESTHOVENS, Rene; LANGHE, Ellen de; LENAERTS, Jan; ANIC, Branimir; BARESIC, Marko; MAYER, Miroslav; UPRUS, Maria; OTSA, Kati; YAVUZ, Sule; GRANEL, Brigitte; RADOMINSKI, Sebastiao Cezar; MUELLER, Carolina de Souza; AZEVEDO, Valderilio Feijo; JIMENEZ, Sergio; BUSQUETS, Joanna; AGACHI, Svetlana; GROPPA, Liliana; CHIABURU, Lealea; RUSSU, Eugen; POPA, Sergei; ZENONE, Thierry; PILECKYTE, Margarita; STEBBINGS, Simon; HIGHTON, John; MATHIEU, Alessandro; VACCA, Alessandra; SAMPAIO-BARROS, Percival D.; YOSHINARI, Natalino H.; MARANGONI, Roberta G.; MARTIN, Patricia; FUOCCO, Luiza; STAMP, Lisa; CHAPMAN, Peter; O'DONNELL, John; SOLANKI, Kamal; DOUBE, Alan; VEALE, Douglas; O'ROURKE, Marie; LOYO, Esthela; LI, Mengtao; MOHAMED, Walid Ahmed Abdel Atty; ROSATO, Edoardo; AMOROSO, Antonio; GIGANTE, Antonietta; OKSEL, Fahrettin; YARGUCU, Figen; TANASEANU, Cristina-Mihaela; POPESCU, Monica; DUMITRASCU, Alina; TIGLEA, Isabela; FOTI, Rosario; CHIRIEAC, Rodica; ANCUTA, Codrina; FURST, Daniel E.; VILLIGER, Peter; ADLER, Sabine; LAAR, Jacob van; KAYSER, Cristiane; EDUARDO, Andrade Luis C.; FATHI, Nihal; HASSANIEN, Manal; LEFEBVRE, Paloma Garcia de la Pena; RUBIO, Silvia Rodriguez; EXPOSITO, Marta Valero; SIBILIA, Jean; CHATELUS, Emmanuel; GOTTENBERG, Jacques Eric; CHIFFLOT, Helene; LITINSKY, Ira; EMERY, Paul; BUCH, Maya; GALDO, Francesco Del; VENALIS, Algirdas; BUTRIMIENE, Irena; VENALIS, Paulius; RUGIENE, Rita; KARPEC, Diana; SAKETKOO, Lesley Ann; LASKY, Joseph A.; KERZBERG, Eduardo; MONTOYA, Fabiana; COSENTINO, Vanesa; LIMONTA, Massimiliano; BRUCATO, Antonio Luca; LUPI, Elide; ROSNER, Itzhak; ROZENBAUM, Michael; SLOBODIN, Gleb; BOULMAN, Nina; RIMAR, Doron; COUTO, Maura; SPERTINI, Francois; RIBI, Camillo; BUSS, Guillaume; KAHL, Sarah; HSU, Vivien M.; CHEN, Fei; MCCLOSKEY, Deborah; MALVEAUX, Halina; PASQUALI, Jean Louis; MARTIN, Thierry; GORSE, Audrey; GUFFROY, Aurelien; POINDRON, Vincent
    Objective Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that is typically subdivided into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) depending on the extent of skin involvement. This subclassification may not capture the entire variability of clinical phenotypes. The European Scleroderma Trials and Research (EUSTAR) database includes data on a prospective cohort of SSc patients from 122 European referral centers. This study was undertaken to perform a cluster analysis of EUSTAR data to distinguish and characterize homogeneous phenotypes without any a priori assumptions, and to examine survival among the clusters obtained. Methods A total of 11,318 patients were registered in the EUSTAR database, and 6,927 were included in the study. Twenty-four clinical and serologic variables were used for clustering. Results Clustering analyses provided a first delineation of 2 clusters showing moderate stability. In an exploratory attempt, we further characterized 6 homogeneous groups that differed with regard to their clinical features, autoantibody profile, and mortality. Some groups resembled usual dcSSc or lcSSc prototypes, but others exhibited unique features, such as a majority of lcSSc patients with a high rate of visceral damage and antitopoisomerase antibodies. Prognosis varied among groups and the presence of organ damage markedly impacted survival regardless of cutaneous involvement. Conclusion Our findings suggest that restricting subsets of SSc patients to only those based on cutaneous involvement may not capture the complete heterogeneity of the disease. Organ damage and antibody profile should be taken into consideration when individuating homogeneous groups of patients with a distinct prognosis.
  • article 11 Citação(ões) na Scopus
    Different ethnic background is associated with distinct clinical profiles in the spondyloarthritides in the North and South of Brazil
    (2019) RIBEIRO, Sandra Lucia Euzebio; CAMPOS, Ana Paula Beckhauser de; PALOMINOS, Penelope Esther; BORTOLUZZO, Adriana Bruscato; COSTA, Marta Aline Coelho da; RIBEIRO, Talita de Oliveira; SAMPAIO-BARROS, Percival Degrava
    The objective of this study was to analyze the clinical profile of the spondyloarthritides (SpA) in distinct Brazilian regions. A common protocol of investigation was prospectively applied to 202 SpA patients, including 138 patients from the South and 64 patients from the North. All the patients were classified as axial or peripheral SpA. Clinical and demographic variables and disease indexes were analyzed. Bonferroni correction was used to adjust the level of significance of each test; results with p value <0.003 were considered statistically relevant. White ethnicity was associated with positive HLA-B27, while non-Whites presented higher frequency of peripheral arthritis, although not statistically significant. When comparing non-White patients from the North with those from the South, the Southerners presented significantly higher scores of Ankylosing Spondylitis Disease Activity Score using C-reactive protein (p=0.001) and Health Assessment Questionnaire (p=0.001). Although not statistically significant, Northern non-White patients were more frequently males, while Southerners had higher frequency of anterior uveitis and higher Bath Ankylosing Spondylitis Disease Activity Index and Ankylosing Spondylitis Quality of Life. Brazilian SpA patients present distinct patterns of disease according to the geographic region, especially regarding the non-White populations.
  • article 9 Citação(ões) na Scopus
    Systemic sclerosis induced by the use of cocaine: is there an association?
    (2019) ANDREUSSI, Rafael; SILVA, Lila Morena Bueno; SILVA, Henrique Carrico da; LUPPINO-ASSAD, Ana Paula; ANDRADE, Danieli Castro O.; SAMPAIO-BARROS, Percival D.
    The association between cocaine abuse and systemic sclerosis (SSc) is rarely described. Two new cases of this association are presented: two young adults, after using inhaled cocaine for a few years, were diagnosed with SSc. While a 24 year-old white female patient presented with diffuse SSc with multiple digital ulcers and scleroderma renal crisis (SRC), a 27 year-old male patient presented limited SSc with skin ulcers and digital gangrene, rapidly evolving to death due to massive intestinal hemorrhage. The authors performed a literature search and found only eight previously published cases. The clinical picture of these patients shows a predominance of vascular involvement, including multiple ulcers and SRC. There is no association with specific SSc autoantibodies. The concomitance of alcohol and other drugs abuse, as well as the presence of drug adulterers, complicates a clear understanding of the role of cocaine in SSc patients.
  • conferenceObject
    HIGH INCIDENCE OF OSTEOPOROTIC FRACTURES IN A SINGLE COHORT OF 700 PATIENTS WITH SYSTEMIC SCLEROSIS
    (2019) SAMPAIO-BARROS, Marilia; BORTOLUZZO, Adriana; SILVA, Henrique Carrico da; LUPPINO-ASSAD, Ana Paula; ANDRADE, Danieli; PEREIRA, Rosa Maria; SAMPAIO-BARROS, Percival
  • conferenceObject
    Impact of Visceral Involvement in the Characterization and Prognosis of Patients Without Skin Involvement Classified as Systemic Sclerosis (SSc) According to 2013 ACR/EULAR Criteria in a Large Single Cohort
    (2019) RIBEIRO, Ana; LUPPINO-ASSAD, Ana Paula; SILVA, Henrique; PRADO, Leandro; ANDRADE, Danieli; SAMPAIO-BARROS, Percival Degrava
  • conferenceObject
    Distinctive Pattern of LTBI Screening Parameters in Ankylosing Spondylitis (AS) and Psoriatic Arthritis (PsA) in Endemic Areas
    (2019) SHIMABUCO, Andrea; RIBEIRO, Ana Cristina de Medeiros; MIOSSI, Renata; BONFIGLIOLI, Karina; MORAES, Julio Cesar Bertacini; GONCALVES, Celio; SAMPAIO-BARROS, Percival; GOLDENSTEIN-SCHAINBERG, Claudia; SOUZA, Fernando Henrique; PRADO, Leandro; UGOLINI-LOPES, Michelle Remiao; YUKI, Emily; BONFA, Eloisa; SAAD, Carla Goncalves Schahin
  • conferenceObject
    Evaluation of Illness Perception in Systemic Sclerosis Patients with Pulmonary Involvement
    (2019) BUNJES, Bruna Giusto; SAMPAIO-BARROS, Percival Degrava; LUPPINO-ASSAD, Ana Paula
  • article 3 Citação(ões) na Scopus
    Clinical and laboratory profile of juvenile-onset systemic sclerosis in a Brazilian cohort
    (2019) SAMPAIO-BARROS, Percival D.; BORTOLUZZO, Adriana B.; RIO, Ana Paula T. Del; LUPPINO-ASSAD, Ana Paula; ANDRADE, Danieli C. O.; MARQUES-NETO, Joao Francisco
    Objective: To characterize the clinical and laboratory profile of juvenile-onset compared to adult-onset systemic sclerosis in a large Brazilian cohort. Methods: Retrospective analysis of a cohort of 1016 systemic sclerosis patients followed at the Scleroderma Outpatient Clinic from two referral university centers in Brazil. Patients were classified as systemic sclerosis according to the 1980 American College of Rhaumatology (ACR) criteria. Juvenile-onset systemic sclerosis was defined if age at onset was Results: Thirty-one (3.1%) patients were classified as juvenile-onset systemic sclerosis. These patients were predominantly females (90.3%), Caucasians (71.0%), and presented diffuse systemic sclerosis (51.6%), with mean age at onset of 12.71 years. Compared to the adult-onset patients, juvenile onset was associated with diffuse systemic sclerosis (p < 0.001), calcinosis (p < 0.001), myositis (p = 0.050), and lower frequency of interstitial lung disease (p = 0.050), pulmonary hypertension (p = 0.035), and esophageal (p = 0.005) involvement. Conclusion: Juvenile-onset systemic sclerosis characterized a distinct clinical pattern in this large series of systemic sclerosis patients, since it was predominantly associated with diffuse systemic sclerosis without significant organ involvement.
  • conferenceObject
    LTBI SCREENING IN SPONDYLOARTHRITIS PATIENTSPRIOR TO ANTI-TNF TREATMENT AND FOLLOW-UP IN AN ENDEMIC AREA
    (2019) SHIMABUCO, Andrea; MEDEIROS, Ana; MIOSSI, Renata; BONFIGLIOLI, Karina; MORAES, Julio; GONCALVES, Celio; SAMPAIO-BARROS, Percival D.; GOLDENSTEIN-SCHAINBERG, Claudia; SOUZA, Fernando; PRADO, Leandro; LOPES, Michelle; BONFA, Eloisa; SAAD, Carla
  • article 5 Citação(ões) na Scopus
    Distal radius and tibia bone microarchitecture impairment in female patients with diffuse systemic sclerosis
    (2019) SAMPAIO-BARROS, M. M.; ALVARENGA, J. C.; TAKAYAMA, L.; ASSAD, A. P. L.; SAMPAIO-BARROS, P. D.; PEREIRA, R. M. R.
    A Summary Radius and tibia bone microarchitecture, analyzed through a high-resolution peripheral quantitative computed tomography, were significantly impaired in female patients with diffuse systemic sclerosis compared with healthy controls. Acroosteolysis, quality of life-grip strength, hand disability, and disease duration were significantly associated with this bone deterioration. Introduction The effect of diffuse systemic sclerosis (dSSc) on the bone is not completely understood. The objective of this study was to analyze the volumetric bone mineral density (vBMD), microarchitecture, and biomechanical parameters at the distal radius and tibia using high-resolution peripheral quantitative computed tomography (HR-pQCT, XtremeCT) in female patients with dSSc and identify clinical and laboratory variables associated with these parameters. Methods Thirty-eight women with dSSc and 76 healthy controls were submitted to HR-pQCT at the distal radius and tibia. Clinical and laboratory findings, bone mineral density(BMD), nailfold capillaroscopy (NC), total passive range of motion(ROM), and quality of life (health assessment questionnaire-HAQ) were associated with HR-pQCT (Scanco Medical AG, Bruttisellen, Switzerland) parameters. Multiple linear regression models adjusted for clinical and laboratory variables, ROM and HAQ, were performed. Results Density, microarchitecture, and biomechanical parameters at the distal radius and tibia were significantly impaired in dSSc patients compared with healthy controls (p < 0.001). Multiple linear regression models showed that lower trabecular density (Tb.vBMD) (radius R-2 = 0.561, p = 0.002; and tibia R-2 = 0.533, p = 0.005), and lower trabecular number (Tb.N) (tibia R-2 = 0.533, p = 0.005) were significantly associated with acroosteolysis. Higher trabecular separation (Tb.Sp) was associated with disease duration and higher HAQ-grip strength (radius R-2 = 0.489, p = 0.013), while cortical density (Ct.vBMD) was associated with ROM (radius R-2 = 0.294, p = 0.002). Conclusion Bone microarchitecture in patients with dSSc, analyzed through HR-pQCT, showed impairment of trabecular and cortical bone at distal radius and tibia. Variables associated with hand involvement (acroosteolysis, quality of life-grip strength, and ROM) and disease duration may be considered prognostic factors of this bone impairment.