PERCIVAL DEGRAVA SAMPAIO BARROS
Índice h a partir de 2011
26
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
20 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 20
conferenceObject EPIDEMIOLOGIC PROFILE OF JUVENILE SPONDYLOARTHRITIS COMPARED TO ADULT-ONSET SPONDYLOARTHRITIS IN A LARGE BRAZILIAN COHORT(2012) DUARTE, A. P.; MARQUES, C. D. L.; BORTOLUZZO, A. B.; GONCALVES, C. R.; SILVA, Braga J. A. da; XIMENES, A. C.; BERTOLO, M. B.; RIBEIRO, S. L.; KEISERMAN, M.; MENIN, R.; SKARE, T. L.; CARNEIRO, S.; AZEVEDO, V. F.; VIEIRA, W. P.; ALBUQUERQUE, E. N.; BIANCHI, W. A.; BONFIGLIOLI, R.; CAMPANHOLO, C.; CARVALHO, H. M. S.; COSTA, I. P.; KOHEM, C. L.; LEITE, N. H.; LIMA, S. A. L.; MEIRELLES, E. S.; PEREIRA, I. A.; PINHEIRO, M. M.; POLITO, E.; RESENDE, G. G.; ROCHA, F. A. C.; SANTIAGO, M. B.; SAUMA, M. F. L. C.; VALIM, V.; SAMPAIO-BARROS, P. D.- HIGH RATES OF WORK DISABILITY IN PATIENTS WITH PSORIATIC ARTHRITIS(2015) GASPARI, C. N. De; GOLDEINSTEIN-SCHAINBERG, C.; PRETTI, F. Z.; SILVA, T. C. P.; GONCALVES, C. R.; SAMPAIO-BARROS, P. D.; SAAD, C. G. S.; MORAES, J. C. B.
- Pan American League of Associations for Rheumatology recommendations for the management of axial spondyloarthritis(2023) BAUTISTA-MOLANO, Wilson; FERNANDEZ-AVILA, Daniel G.; BRANCE, Maria Lorena; PEDRETTI, Maria Gabriela Avila; BURGOS-VARGAS, Ruben; CORBACHO, Ines; COSENTINO, Vanesa Laura; COTO, Jose Francisco Diaz; HO, Enrique Giraldo; RESENDE, Gustavo Gomes; GUTIERREZ, Luis Arturo; GUTIERREZ, Marwin; VODNIZZA, Sebastian Eduardo Ibanez; JAUREGUI, Edwin; OCAMPO, Vanessa; RIVERO, Daniel Ruben Palleiro; PALOMINOS, Penelope Esther; TENA, Cesar Pacheco; QUICENO, Guillermo Andres; SALDARRIAGA-RIVERA, Lina Maria; SOMMERFLECK, Fernando Andres; SARIEGO, Annelise Goecke; BARREZUETA, Claudia Vera; ESPINOZA, Luis Enrique Vega; HINOJOSA, Oscar Vega; CITERA, Gustavo; LOZADA, Carlos; SAMPAIO-BARROS, Percival D.; SCHNEEBERGER, Emilce; SORIANO, Enrique R.Axial spondyloarthritis (axSpA) comprises a spectrum of chronic inflammatory manifestations affecting the axial skeleton and represents a challenge for diagnosis and treatment. Our objective was to generate a set of evidence-based recommendations for the management of axSpA for physicians, health professionals, rheumatologists and policy decision makers in Pan American League of Associations for Rheumatology (PANLAR) countries. Grading of Recommendations, Assessment, Development and Evaluation-ADOLOPMENT methodology was used to adapt existing recommendations after performing an independent systematic search and synthesis of the literature to update the evidence. A working group consisting of rheumatologists, epidemiologists and patient representatives from countries within the Americas prioritized 13 topics relevant to the context of these countries for the management of axSpA. This Evidence-Based Guideline article reports 13 recommendations addressing therapeutic targets, the use of NSAIDs and glucocorticoids, treatment with DMARDs (including conventional synthetic, biologic and targeted synthetic DMARDs), therapeutic failure, optimization of the use of biologic DMARDs, the use of drugs for extra-musculoskeletal manifestations of axSpA, non-pharmacological interventions and the follow-up of patients with axSpA.
- Rosa Maria Rodrigues Pereira (1958-2022) IN MEMORIAM(2023) JORGETTI, Vanda; PD, Sampaio-Barros; SK, Shinjo; BONFA, Eloisa
article 0 Citação(ões) na Scopus Rosa Maria Rodrigues Pereira(2022) JORGETTI, Vanda; SAMPAIO-BARROS, Percival Degrava; SHINJO, Samuel Katsuyuki; BONFA, Eloisa- Critical digital ischaemia in systemic sclerosis exacerbated by multiple myeloma: A case report(2023) FRANCO, Andre Silva; POLHO, Gabriel Berlingieri; ASSAD, Ana Paula Luppino; MIOSSI, Renata; SAMPAIO-BARROS, Percival DegravaIntroduction: The overlapping of systemic sclerosis with hematologic malignancy has been described previously in the literature. This case report presents a patient with systemic sclerosis and multiple myeloma who had severe digital ischaemia that culminated in the amputation of several fingers. Case report: A 65-year-old White female patient was diagnosed with limited systemic sclerosis in 2002, smouldering multiple myeloma IgG/kappa in 2017 and liver cirrhosis in 2018 due to autoimmune hepatitis. In 2021, she was admitted to the emergency room with dry ischaemia of all fingers and toes despite optimized therapy, associated with visual blurring. The diagnostic hypothesis was hyperviscosity syndrome associated with multiple myeloma reactivation. The patient underwent chemotherapy and despite initial laboratory improvement, 19 digits required amputation. Conclusion: Although the association between systemic sclerosis and multiple myeloma is rare, it should be remembered in cases of significant worsening of Raynaud's phenomenon. Causes unrelated to systemic sclerosis should also be considered in the presence of severe exacerbations in patients with other comorbidities.
- EFFICACY OF UPADACITINIB IN PATIENTS WITH NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS IN EARLY VERSUS ESTABLISHED DISEASE(2023) NAVARRO-COMPAN, V.; BOSCH, F. Van den; SAMPAIO-BARROS, P. D.; GANZ, F.; BILJAN, A.; DUAN, Y.; D'SILVA, K.; WUNG, P.; OSTOR, A.; RAMIRO, S.
- HLA-B27 positivity in a large miscegenated population of 5,389,143 healthy blood marrow donors in Brazil(2023) RESENDE, Gustavo Gomes; SAAD, Carla Goncalves Schahin; OLIVEIRA, Danielli Cristina Muniz de; BUENO FILHO, Julio Silvio de Sousa; SAMPAIO-BARROS, Percival Degrava; PINHEIRO, Marcelo de MedeirosBackgroundThe prevalence of HLA-B27 gene positivity in healthy Caucasian communities varies between 8 and 14%. However, there is a lack of information in countries with a high rate of miscegenation, such as Brazil.AimTo estimate the frequency of HLA-B27 in the Brazilian general population using a large national registry database.MethodsThis is a cross-sectional ecological study using the Brazilian Registry of Volunteer Bone Marrow Donors (REDOME) database on HLA-B27 allelic frequency and proportion of positives of healthy donors (18-60 years old). Data were analyzed according to sex, age, race (by self-reported skin color recommended by the Brazilian Institute of Geography and Statistics - IBGE), and geographic region of residence.ResultsFrom 1994 to 2022, a total of 5,389,143 healthy bone marrow donors were included. The overall positivity for HLA-B27 was 4.35% (CI 95% 4.32-4.37%), regardless of sex and age (57.2% were women, mean age was 41.7yo). However, there was a difference between races: 4.85% in Whites; 2.92% in Blacks; 3.76% in Pardos (Browns i.e. mixed races); 3.95% in Amarelos (Yellows i.e. Asian Brazilians); and 3.18% in Indigenous. There was also a difference regarding geographic region of residence (North: 3.62%; Northeast: 3.63%; Southeast: 4.29%; Midwest: 4.5% and 5.25% in South). The homozygosity rate for the HLA-B27 was 1.32% of all the positives and only 0.06% in the general population.ConclusionsOur findings provide the first Brazilian national prevalence for HLA-B27 in 4.35%. There is a gradient gene positivity from North to South, suggesting that the genetic background related to the miscegenation due to colonization, slavery, and some later waves of immigration together with internal migratory flows, could explain our findings.
- Strong response after fourth dose of mRNA COVID-19 vaccine in autoimmune rheumatic diseases patients with poor response to inactivated vaccine(2022) AIKAWA, Nadia E.; KUPA, Leonard V. K.; SILVA, Clovis A.; SAAD, Carla G. S.; PASOTO, Sandra G.; YUKI, Emily F. N.; FUSCO, Solange R. G.; SHINJO, Samuel K.; ANDRADE, Danieli C. O.; SAMPAIO-BARROS, Percival D.; PEREIRA, Rosa M. R.; CHASIN, Anna C. S.; SHIMABUCO, Andrea Y.; LUPPINO-ASSAD, Ana P.; LEON, Elaine P.; LOPES, Marta H.; ANTONANGELO, Leila; MEDEIROS-RIBEIRO, Ana C.; BONFA, EloisaObjectives. To assess immunogenicity of a heterologous fourth dose of an mRNA (BNT162b2) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in autoimmune rheumatic diseases (ARD) patients with poor/non-response to inactivated vaccine (Sinovac-CoronaVac). Methods. A total of 164 ARD patients who were coronavirus disease 2019 (COVID-19) poor/non-responders (negative anti-SARS-CoV-2 S1/S2 IgG and/or neutralizing antibodies-NAb) to the third dose of Sinovac-CoronaVac received an additional heterologous dose of mRNA (BNT162b2) 3 months after last dose. IgG and NAb were evaluated before and after the fourth dose. Results. Significant increases were observed after the fourth dose in IgG (66.4 vs 95.1%, P < 0.001), NAb positivity (5.5 vs 83.5%, P < 0.001) and geometric mean titre (29.5 vs 215.8 AU/ml, P < 0.001), and 28 (17.1%) remained poor/non-responders. Patients with negative IgG after a fourth dose were more frequently under rituximab (P = 0 .001) . Negative NAb was associated with older age (P = 0.015), RA (P = 0 .002) , SSc (P = 0 .026) , LEF (P = 0 .01 6) and rituximab use (P = 0.007) . In multiple logistic regression analysis, prednisone dose >= 7.5 mg/day (OR =0.34; P = 0.047) , LEF (OR =0.32, P = 0.036) and rituximab use (OR =0.19, P = 0.022) were independently associated with negative NAb after the fourth vaccine dose. Conclusions. This is the largest study to provide evidence of a remarkable humoral response after the fourth dose of heterologous mRNA SARS-CoV-2 vaccination in ARD patients with poor/non-response to the third dose of an inactivated vaccine. We further identified that treatment, particularly rituximab and prednisone, impaired antibody response to this additional dose.
conferenceObject DISEASE PATTERNS OF PSORIATIC ARTHRITIS IN A LARGE SERIES OF BRAZILIAN PATIENTS WITH SPONDYLOARTHRITIS(2012) BONFIGLIOLI, R.; BONOLUZZO, A. B.; GONCALVES, C. R.; SILVA, Braga J. A. da; XIMENES, A. C.; BERTOLO, M. B.; RIBEIRO, S. L.; KEISERMAN, M.; MENIN, R.; SKARE, T. L.; CARNEIRO, S.; AZEVEDO, V. F.; VIEIRA, W. P.; ALBUQUERQUE, E. M. N.; BIANCHI, W. A.; CAMPANHOLO, C.; CARVALHO, H. M. S.; COSTA, I. P.; DUARTE, A. P.; KOHEM, C. L.; LEITE, N. H.; LIMA, S. A. L.; MEIRELLES, E. S.; PEREIRA, I. A.; PINHEIRO, M. M.; POLITO, E.; RESENDE, G. G.; ROCHA, F. A. C.; SANTIAGO, M. B.; SAUMA, M. F. L. C.; VALIN, V.; SAMPAIO-BARROS, P. D.