EURIPEDES CONSTANTINO MIGUEL FILHO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Psiquiatria, Faculdade de Medicina - Docente
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina - Líder
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- Y Editorial: Obsessive-compulsive disorder (OCD) across the lifespan: Current diagnostic challenges and the search for personalized treatment(2022) SHAVITT, Roseli G.; HEUVEL, Odile A. van den; LOCHNER, Christine; REDDY, Y. C. Janardhan; MIGUEL, Euripedes C.; SIMPSON, Helen Blair
- Screen time and psychopathology: investigating directionality using cross-lagged panel models(2022) BADO, Patricia; SCHAFER, Julia; SIMIONI, Andre R.; BRESSAN, Rodrigo A.; GADELHA, Ary; PAN, Pedro M.; MIGUEL, Euripedes C.; ROHDE, Luis A.; SALUM, Giovanni A.
- Towards a definitive symptom structure of obsessive-compulsive disorder: a factor and network analysis of 87 distinct symptoms in 1366 individuals(2022) CERVIN, Matti; MIGUEL, Euripedes C.; GULER, Aysegul Selcen; FERRAO, Ygor A.; ERDOGDU, Ayse Burcu; LAZARO, Luisa; GOKCE, Sebla; GELLER, Daniel A.; YULAF, Yasemin; BASGUL, Saziye Senem; OZCAN, Ozlem; KARABEKIROGLU, Koray; FONTENELLE, Leonardo F.; YAZGAN, Yanki; STORCH, Eric A.; LECKMAN, James F.; ROSARIO, Maria Conceicao do; MATAIX-COLS, DavidBackground The symptoms of obsessive-compulsive disorder (OCD) are highly heterogeneous and it is unclear what is the optimal way to conceptualize this heterogeneity. This study aimed to establish a comprehensive symptom structure model of OCD across the lifespan using factor and network analytic techniques. Methods A large multinational cohort of well-characterized children, adolescents, and adults diagnosed with OCD (N = 1366) participated in the study. All completed the Dimensional Yale-Brown Obsessive-Compulsive Scale, which contains an expanded checklist of 87 distinct OCD symptoms. Exploratory and confirmatory factor analysis were used to outline empirically supported symptom dimensions, and interconnections among the resulting dimensions were established using network analysis. Associations between dimensions and sociodemographic and clinical variables were explored using structural equation modeling (SEM). Results Thirteen first-order symptom dimensions emerged that could be parsimoniously reduced to eight broad dimensions, which were valid across the lifespan: Disturbing Thoughts, Incompleteness, Contamination, Hoarding, Transformation, Body Focus, Superstition, and Loss/Separation. A general OCD factor could be included in the final factor model without a significant decline in model fit according to most fit indices. Network analysis showed that Incompleteness and Disturbing Thoughts were most central (i.e. had most unique interconnections with other dimensions). SEM showed that the eight broad dimensions were differentially related to sociodemographic and clinical variables. Conclusions Future research will need to establish if this expanded hierarchical and multidimensional model can help improve our understanding of the etiology, neurobiology and treatment of OCD.
- Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action(2022) TERRA, Tauana; SCHAFER, Julia L.; PAN, Pedro M.; COSTA, Angelo Brandelli; CAYE, Arthur; GADELHA, Ary; MIGUEL, Euripedes C.; BRESSAN, Rodrigo A.; ROHDE, Luis A.; SALUM, Giovanni A.Background: Lesbian, Gay, Bisexual, Transgender, Queer, and Asexual (LGBTQA+) youth have a greater chance of experiencing stressful life events when compared to cisgender heterosexual peers, which can lead to mental health problems. We aimed to estimate the prevalence of mental disorders among LGBTQA+ youths from two large cities in Brazil. Methods: Participants were 13-22 years old youths from the 3rd wave of the Brazilian High-Risk Cohort for Psychiatric Disorders (n = 1475). Mental disorders were assessed using the Development and Well-Being Behavior Assessment. Sexual orientation and gender identity were assessed using a self-report confidential questionnaire. Data were analyzed through logistic regressions (adjusting for sociodemographic) using sampling weights to account for attrition and our oversampling high-risk design. Results: 15.18% of the sample described themselves as LGBTQA+. The LGBTQA+ group presented higher rates of anxiety disorders (30.14% vs. 13.37%; OR = 3.37; 95%CI:2.51-4.50), depressive disorders (27.75% vs. 15.34%; OR = 2.17; 95%CI:1.60-2.93) and post-traumatic stress disorder (4.98% vs. 2.25%; OR = 4.20; 95% CI:2.24-7.82), if compared with the cisgender heterosexual group. No difference was found for conduct disorders (2.97% vs. 5.21%; OR = 0.82; 95%CI:0.35-1.65) or attention deficit hyperactivity disorder (5.92% vs. 3.28%; OR = 1.56; 95%CI:0.83-2.79). Limitations: Although recruitment was performed at 57 schools in the two cities, sampling was non-probabilistic and included only urban areas, which might bias prevalence estimates and group comparisons. Conclusions: Our results elucidate the mental health disparities between LGBTQA+ people and cisgender heterosexuals in Brazil. It highlights the need to promote the inclusion of this population in policy formulation and support actions to mitigate the suffering related to sexual orientation and gender identity.
- Childhood individual and family modifiable risk factors for criminal conviction: a 7-year cohort study from Brazil(2022) ZIEBOLD, Carolina; EVANS-LACKO, Sara; ANDRADE, Mario Cesar Rezende; HOFFMANN, Mauricio Scopel; FONSECA, Lais; BARBOSA, Matheus Ghossain; PAN, Pedro Mario; MIGUEL, Euripedes; BRESSAN, Rodrigo Affonseca; ROHDE, Luis Augusto; SALUM, Giovanni Abrahao; MARI, Jair de Jesus; GADELHA, AryCrime is a major public problem in low- and middle-income countries (LMICs) and its preventive measures could have great social impact. The extent to which multiple modifiable risk factors among children and families influence juvenile criminal conviction in an LMIC remains unexplored; however, it is necessary to identify prevention targets. This study examined the association between 22 modifiable individual and family exposures assessed in childhood (5-14 years, n = 2511) and criminal conviction at a 7-year follow-up (13-21 years, n = 1905, 76% retention rate) in a cohort of young people in Brazil. Population attributable risk fraction (PARF) was computed for significant risk factors. Criminal convictions were reported for 81 (4.3%) youths. Although most children living in poverty did not present criminal conviction (89%), poverty at baseline was the only modifiable risk factor significantly associated with crime (OR 4.14, 99.8% CI 1.38-12.46) with a PARF of 22.5% (95% CI 5.9-36.1%). It suggests that preventing children's exposure to poverty would reduce nearly a quarter of subsequent criminal convictions. These findings highlight the importance of poverty in criminal conviction, as it includes several deprivations and suggest that poverty eradication interventions during childhood may be crucial for reducing crime among Brazilian youth.
- Obsessive-Compulsive Disorder Treatment Based on Neurocircuits(2022) SHEPHARD, Elizabeth; STERN, Emily R.; MIGUEL, Euripedes C.Psychiatric disorders affect close to 30% of the global population and ac-count for more than 7% of the global burden of disease. To address this prob-lem, new treatment approaches are re-quired that target the heterogeneity of psychiatric conditions and their un-derlying neurobiological bases. In this article, we use obsessive-compulsive disorder (OCD) as an example to sum-marize recent conceptual work that has attempted to offer solutions to bet -ter understanding heterogeneity and improving effectiveness of psychiatric treatments. Specifically, we highlight hypothetical ""clinical profiles"" of OCD that are based on neurocognitive alter-ations (eg, dysregulated fear), which are underpinned by dysfunctions in specific neurocircuits (eg, hyperactive frontolimbic circuit function) and could be ameliorated with neurocircuit-based treatments. While this model of OCD is not yet ready for clinical use, this ap-proach to understanding OCD may be helpful for clinicians in understanding individual patients under their care and the mechanisms involved in different treatments for OCD. [Psychiatr Ann. 2022;52(4);152-156.]
- Factor structure of the Dimensional Yale-Brown Obsessive-Compulsive Scale in a large sample of adults with obsessive-compulsive disorder(2022) BATISTUZZO, Marcelo C.; FONTENELLE, Leonardo; FERRAO, Ygor A.; ROSARIO, Maria C.; MIGUEL, Euripedes C.; FATORI, DanielObjectives: Although the Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS) is a widely used instrument for assessing different obsessive-compulsive symptom dimensions, its factor structure has never been studied in a Brazilian population. Thus, we aimed to assess the goodness-of fit indexes and factor loadings of two higher-order models of the DY-BOCS using confirmatory factor analysis (CFA) in a large obsessive-compulsive disorder (OCD) sample. Methods: We tested two CFA models in a sample of 955 adults with OCD who had been assessed with the DY-BOCS in a cross-sectional multi-site study. The first model encompassed the symptom checklist (present or absent), whereas the second focused on items related to severity scores. Results: Both models presented adequate goodness-of-fit indexes. The comparative fit index, Tucker Lewis index, and omega were 4 0.9, while the root mean square error of approximation was p 0.06 for both models. Factor loadings for each item of each dimension are presented and discussed. Conclusion: Higher-order factor models showed adequate goodness-of-fit indexes, indicating that they appropriately measured OCD dimensions in this Brazilian population.
bookPart Prefácio(2022) MIGUEL, Euripedes Constantino- Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation(2022) BUSATTO, Geraldo F.; ARAUJO, Adriana Ladeira de; CASTALDELLI-MAIA, Joao Mauricio; DAMIANO, Rodolfo Furlan; IMAMURA, Marta; GUEDES, Bruno F.; PINNA, Fabio de Rezende; SAWAMURA, Marcio Valente Yamada; MANCINI, Marcio C.; SILVA, Katia R. da; GARCIA, Michelle L.; SUMITA, Nairo; BRUNONI, Andre Russowsky; DUARTE, Alberto J. da Silva; BURDMANN, Emmanuel A.; KALLAS, Esper G.; CERRI, Giovanni G.; NITRINI, Ricardo; BENTO, Ricardo F.; ROCHA, Vanderson Geraldo; SOUZA, Heraldo Possolo de; MIGUEL, Euripedes C.; CARVALHO, Carlos R. R. de; FORLENZA, Orestes V.; BATISTELLA, Linamara RizzoBackground Despite the multitude of clinical manifestations of post-acute sequelae of SARS-CoV-2 infection (PASC), studies applying statistical methods to directly investigate patterns of symptom co-occurrence and their biological correlates are scarce. Methods We assessed 30 symptoms pertaining to different organ systems in 749 adults (age = 55 +/- 14 years; 47% female) during in-person visits conducted at 6-11 months after hospitalization due to coronavirus disease 2019 (COVID-19), including six psychiatric and cognitive manifestations. Symptom co-occurrence was initially investigated using exploratory factor analysis (EFA), and latent variable modeling was then conducted using Item Response Theory (IRT). We investigated associations of latent variable severity with objective indices of persistent physical disability, pulmonary and kidney dysfunction, and C-reactive protein and D-dimer blood levels, measured at the same follow-up assessment. Results The EFA extracted one factor, explaining 64.8% of variance; loadings were positive for all symptoms, and above 0.35 for 16 of them. The latent trait generated using IRT placed fatigue, psychiatric, and cognitive manifestations as the most discriminative symptoms (coefficients > 1.5, p < 0.001). Latent trait severity was associated with decreased body weight and poorer physical performance (coefficients > 0.240; p <= 0.003), and elevated blood levels of C-reactive protein (coefficient = 0.378; 95% CI 0.215-0.541; p < 0.001) and D-dimer (coefficient = 0.412; 95% CI 0.123-0.702; p = 0.005). Results were similar after excluding subjects with pro-inflammatory comorbidities. Conclusions Different symptoms that persist for several months after moderate or severe COVID-19 may unite within one latent trait of PASC. This trait is dominated by fatigue and psychiatric symptoms, and is associated with objective signs of physical disability and persistent systemic inflammation.
- Double cone coil repetitive transcranial magnetic stimulation for severe obsessive-compulsive disorder after reversible cerebral vasoconstriction syndrome with intracerebral hemorrhage: a case report(2022) SILVEIRA, Julia Belizario; DAMIANO, Rodolfo Furlan; NETO, Emilio Abelama; GOMES, Raphael Neves dos Santos Mosqueira; KLEIN, Izio; BORRIONE, Lucas; SUDBRACK, Pedro; GENTIL, Andre Felix; SHEPHARD, Elizabeth; BRUNONI, Andre Russowski; MIGUEL, Euripedes Constantino; ECHEVARRIA, Marco Antonio Nocito