FRANCISCO CARLOS DA COSTA DARRIEUX
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
13 resultados
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- Age is associated with time in therapeutic range for warfarin therapy in patients with atrial fibrillation(2016) MARCATTO, Leiliane Rodrigues; SACILOTTO, Luciana; DARRIEUX, Francisco Carlos da Costa; HACHUL, Denise Tessariol; SCANAVACCA, Mauricio Ibrahim; KRIEGER, Jose Eduardo; PEREIRA, Alexandre Costa; SANTOS, Paulo Caleb Junior LimaBackground: Warfarin is the most prescribed oral anticoagulant used for preventing stroke in patients with atrial fibrillation. Time in the therapeutic range (TTR) has been accepted as the best method to evaluate the quality of warfarin therapy. The main aim of the present study was to evaluate the impact of variables on the time in the therapeutic range for warfarin therapy in patients with atrial fibrillation from a referral cardiovascular hospital. Methods: This retrospective study included 443 patients were included (190 patients with age < 65 years and 253 patients with age >= 65 years) from 2011 to 2014 and TTR was computed according to Rosendaal's method. Results: Patients with age >= 65 years had higher TTR value (67+/-22%) compared with patients with < 65 years (60+/-24%) (p = 0.004). In a linear regression model, only age >= 65 years emerged as a significant predictor of greater TTR values. In multivariate logistic regression model, the variable age = 65 years was associated with higher OR for having a TTR higher than the median value (OR = 2.17, p < 0.001). Conclusion: We suggest that the age influenced TTR through greater drug adherence. Strategies for increasing drug adherence might improve quality of warfarin anticoagulation.
bookPart Abordagem do paciente com arritmia(2016) DARRIEUX, Francisco; SACILOTTO, Luciana; PAOLA, Angelo de- Evaluation of a pharmacogenetic-based warfarin dosing algorithm in patients with low time in therapeutic range - study protocol for a randomized controlled trial(2016) MARCATTO, Leiliane Rodrigues; SACILOTTO, Luciana; BUENO, Carolina Tosin; FACIN, Mirella; STRUNZ, Celia Maria Cassaro; DARRIEUX, Francisco Carlos Costa; SCANAVACCA, Mauricio Ibrahim; KRIEGER, Jose Eduardo; PEREIRA, Alexandre Costa; SANTOS, Paulo Caleb Junior LimaBackground: Time in therapeutic range (TTR) is a measurement of quality of warfarin therapy and lower TTR values (<50%) are associated with greater risk of thromboembolic and bleeding events. Recently, we developed a pharmacogenetic-based warfarin dosing algorithm specifically calibrated for a Brazilian patient sample. The aims of this study are: to evaluate the impact of a genetic-based algorithm, compared to traditional anticoagulation, in the time to achieve the therapeutic target and in TTR percentage; and to assess the cost-effectiveness of genotype-guided warfarin dosing in a specific cohort of patients with low TTR (<50%) from a tertiary cardiovascular hospital. Methods/design: This study is a randomized controlled trial in patients (n = 300) with atrial fibrillation with TTR <50%, based on the last three INR values. At the first consultation, patients will be randomized into two groups: TA group (traditional anticoagulation) and PA group (pharmacogenetic anticoagulation). For the first group, the physician will adjust the dose according to current INR value and, for the second group, a pharmacogenetic algorithm will be used. At the second, third, fourth and fifth consultations (with an interval of 7 days each) INR will be measured and, if necessary, the dose will be adjusted based on guidelines. Afterwards, patients who are INR stable will begin measuring their INR in 30 day intervals; if the patient's INR is not stable, the patient will return in 7 days for a new measurement of the INR. Outcomes measures will include the time to achieve the therapeutic target and the percentage of TTR at 4 and 12 weeks. In addition, as a secondary end-point, pharmacoeconomic analysis will be carried out. Ethical approval was granted by the Ethics Committee for Medical Research on Human Beings of the Clinical Hospital of the University of Sao Paulo Medical School. Discussion: This randomized study will include patients with low TTR and it will evaluate whether a population-specific genetic algorithm might be more effective than traditional anticoagulation for a selected group of poorly anticoagulated patients.
article Cardiac Arrhythmias Guideline in Children and Congenital Cardiomyopathies SOBRAC and DCC - CP(2016) MAGALHAES, L. P.; GUIMARAES, I. C. B.; MELO, S. L.; MATEO, E. I. P.; ANDALAFT, R. B.; XAVIER, L. F. R.; LORGA FILHO, A. M.; FAGUNDES, A. A.; MOREIRA, D. A. R.; HACHUL, D. T.; STERNICK, E. B.; ANDREA, E. M.; CANNAVAN, F. P. S.; OLIVEIRA, F. J. B.; DARRIEUX, F. C. C.; LIMA, G. G.; ATIE, J.; ELIAS NETO, J.; ZIMERMAN, L. I.; MIANA, L.; PELLANDA, L. C.; SACILOTTO, L.; JATENE, M. B.; SOARES, M. M.; BINOTTO, M. A.; SCANAVACCA, M. I.; OLIVEIRA JUNIOR, N. A.; ZIELINSKY, P.; SALERNO, P. R.; TEIXEIRA, R. A.; KUNIYOSHI, R. R.; COSTA, R.; SCHAMES NETO, S.; PEDRA, S. R. F. F.; GIMENEZ, S. C.; WU, T. C.; AIELLO, V. D.bookPart Arritmias(2016) FONSECA, Wallyson Pereira; DARRIEUX, Francisco- II BRAZILIAN GUIDELINES OF ATRIAL FIBRILLATION Introduction(2016) MAGALHAES, L. P.; FIGUEIREDO, M. J. O.; CINTRA, F. D.; SAAD, E. B.; KUNIYISHI, R. R.; TEIXEIRA, R. A.; LORGA FILHO, A. M.; D'AVILA, A.; V, A. A. de Paola; KALIL, C. A.; MOREIRA, D. A. R.; SOBRAL FILHO, D. C.; STERNICK, E. B.; DARRIEUX, F. C. C.; FENELON, G.; LIMA, G. G.; ATIE, J.; MATEOS, J. C. P.; MOREIRA, J. M.; VASCONCELOS, J. T. M.; I, L. Zimerman; SILVA, L. R. L.; SILVA, M. A.; I, M. Scanavacca; SOUZA, O. F.
bookPart Arritmias Cardíacas(2016) SOSA, Eduardo; MELO, Sissy Lara de; PISANI, Cristiano Faria; OLIVEIRA, Barbara; DARRIEUX, Francisco; SCANAVACCA, MauriciobookPart Taquiarritmias supraventriculares: manejo ambulatorial(2016) OLIVETTI, Natália Quintella Sangiorgi; DARRIEUX, Francisco Carlos da Costa- Executive Summary of the II Brazilian Guidelines for Atrial Fibrillation(2016) MAGALHAES, Luiz Pereira de; FIGUEIREDO, Marcio Jansen de Oliveira; CINTRA, Fatima Dumas; SAAD, Eduardo Benchimol; KUNIYOSHI, Ricardo Ryoshim; LORGA FILHO, Adalberto Menezes; D'AVILA, Andre Luiz Buchele; PAOLA, Angelo Amato Vincenzo de; KALIL, Carlos Antonio Abunader; MOREIRA, Dalmo Antonio Ribeiro; SOBRAL FILHO, Dario Celestino; STERNICK, Eduardo Back; DARRIEUX, Francisco Carlos da Costa; FENELON, Guilherme; LIMA, Gustavo Glotz de; ATIE, Jacob; MATEOS, Jose Carlos Pachon; MOREIRA, Jose Marcos; VASCONCELOS, Jose Tarcisio Medeiros de; ZIMERMAN, Leandro Ioschpe; SILVA, Luiz Roberto Leite da; SILVA, Marcio Augusto; SCANAVACCA, Mauricio Ibrahim; SOUZA, Olga Ferreira de
article III DIRECTIVES OF THE BRAZILIAN SOCIETY OF CARDIOLOGY ON ANALYSIS AND ISSUANCE OF ELECTROCARDIOGRAPHIC REPORTS Introduction(2016) PASTORE, C. A.; PINHO, J. A.; PINHO, C.; SAMESIMA, N.; PEREIRA-FILHO, H. G.; KRUSE, J. C. L.; PAIXAO, A.; PEREZ-RIERA, A. R.; RIBEIRO, A. L.; OLIVEIRA, C. A. R.; GOMES, C. I. G.; KAISER, E.; GALVAO, F.; DARRIEUX, F. C. C.; FRANCA, F. F. A. C.; FEITOSA-FILHO, G.; GERMINIANI, H.; AZIZ, J. L.; LEAL, M. G.; MOLINA, M.; OLIVEIRA, N. M. T.; OLIVEIRA, P. A.; SANCHES, P. C. R.; ALMEIDA, R. M.; BARBOSA, R.; TEIXEIRA, R. A.; DOUGLAS, R. A. G.; GUNDIM, R. S.; ATANES, S. M.