DENISE CERQUEIRA PARANAGUA VEZOZZO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
5 resultados
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- Epidemiology of Liver Cancer in Latin America: Current and Future Trends(2020) CARRILHO, Flair Jose; PARANAGUA-VEZOZZO, Denise Cerqueira; CHAGAS, Aline Lopes; ALENCAR, Regiane Saraiva de Souza Melo; FONSECA, Leonardo Gomes daOver 38,000 cases of hepatocellular carcinoma (HCC) are estimated to occur in Latin America annually. The region is characterized by sociocultural heterogeneity and economic disparities, which impose barriers in addressing this major health issue. A significant proportion of patients are still diagnosed in the later stages of the disease, although efforts to implement effective screening programs have been reported by referral centers. While viral hepatitis remains the predominant etiology of liver disease among HCC cases in Latin America, a high prevalence of fatty liver disease in the region is a matter of concern, reflecting the current scenario in many Western countries. In addition, other risk factors such as alcohol, aflatoxin, and early-onset HCC in hepatitis B virus infection contribute to the burden of HCC in Latin America. Interventions to increase screening coverage, expand healthcare access, and implement continuing medical training are key challenges to be overcome.
- BRAZILIAN SOCIETY OF HEPATOLOGY UPDATED RECOMMENDATIONS FOR DIAGNOSIS AND TREATMENT OF HEPATOCELLULAR CARCINOMA(2020) CHAGAS, Aline Lopes; MATTOS, Angelo Alves de; CARRILHO, Flair José; BITTENCOURT, Paulo Lisboa; VEZOZZO, Denise Cerqueira Paranaguá; HORVAT, Natally; ROCHA, Manoel de Souza; ALVES, Venâncio Avancini Ferreira; CORAL, Gabriela Perdomo; ALVARES-DA-SILVA, Mario Reis; BARROS, Fabio Marinho do Rego; MENEZES, Marcos Roberto; MONSIGNORE, Lucas Moretti; COELHO, Fabricio Ferreira; SILVA, Renato Ferreira da; SILVA, Rita de Cássia Martins Alves; BOIN, Ilka de Fatima Santana Ferreira; D`ALBUQUERQUE, Luiz Augusto Carneiro; GARCIA, José Huygens Parente; FELGA, Guilherme Eduardo Gonçalves; MOREIRA, Airton Mota; BRAGHIROLI, Maria Ignez Freitas Melro; HOFF, Paulo Marcelo Gehm; MELLO, Vivianne Barretto de; DOTTORI, Mariana Fonseca; BRANCO, Tiago Pugliese; SCHIAVON, Leonardo de Lucca; COSTA, Thaisa de Fátima AlmeidaABSTRACT Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. The Brazilian Society of Hepatology (SBH) published in 2015 its first recommendations about the management of HCC. Since then, new data have emerged in the literature, prompting the governing board of SBH to sponsor a single-topic meeting in August 2018 in São Paulo. All the invited experts were asked to make a systematic review of the literature reviewing the management of HCC in subjects with cirrhosis. After the meeting, all panelists gathered together for the discussion of the topics and the elaboration of updated recommendations. The text was subsequently submitted for suggestions and approval of all members of the Brazilian Society of Hepatology through its homepage. The present manuscript is the final version of the reviewed manuscript containing the recommendations of SBH.
- HCC in patients with NAFLD/NASH(2020) STEFANO, J. T.; MALTA, F. De Mello; CAMPOS, P. B. De; ANDRADE, P. F.; PARANAGUá-VEZZOZO, D. C.; CARRILHO, F. J.; OLIVEIRA, C. P.Hepatocellular carcinoma (HCC) associated with NAFLD has been steadily increasing and non-alcoholic steatohepatitis (NASH) is the most rapidly growing risk for liver transplantation in patients with HCC in the last years. In the vast majority of cases, HCC develops in the context of hepatic cirrhosis, but recent data suggest that there is a proportion of patients with NAFLD who are at high risk for HCC in the absence of cirrhosis. Although no study clearly explains the evolution of NAFLD to HCC, researchers suggest that the most likely mechanism involves fatty acid (FA) accumulation in hepatocytes due to predisposing factors, such as MtS, increased oxidative stress, endoplasmic reticulum (ER) stress, mitochondrial dysfunction and chronic endotoxaemia. Genetic and epigenetic changes in pathogenesis and hepatic carcinogenesis potentially serve as potential diagnostic biomarkers and/or therapeutic targets. MicroRNAs (miRNAs) play a key role in the pathogenesis of HCC related to NAFLD by closely regulating lipid metabolism, glucose homeostasis, cell proliferation, apoptosis, and cell migration and differentiation. In other words, there are currently no guidelines for the screening and early detection of NAFLD-related HCC in the absence of cirrhosis. However, there is an increasing number of HCC cases without cirrhosis. Thus, there is a strong interest in identifying biomarkers to detect early detection of HCC risk related to NAFLD progression. © Springer Nature Switzerland AG 2020.
- Liver Elastography in Acute Cellular Rejection After Liver Transplantation(2020) NACIF, Lucas Souto; GOMES, Caroline de Cassia; PARANAGUA-VEZOZZO, Denise; CASSENOTE, Alex Jones Flores; PINHEIRO, Rafael Soares; WAISBERG, Daniel Reis; ROCHA-SANTOS, Vinicius; MARTINO, Rodrigo Bronze de; ARANTES, Rubens Macedo; DUCATTI, Liliana; HADDAD, Luciana; GALVAO, Flavio; ANDRAUS, Wellington; CARRILHO, Flair Jose; D'ALBUQUERQUE, Luiz Carneiro
conferenceObject Hepatocellular carcinoma in patients with autoimmune hepatitis: prevalence and risk factors(2020) VAZ, Nayana Fonseca; MARGON, Julia Fadini; MOUTINHO, Bruna Damasio; BRAGA, Michele Harriz; TANI, Claudia Megumi; ALENCAR, Regiane Saraiva de Souza Melo; SAUD, Lisa Rodrigues da Cunha; VEZOZZO, Denise Cerqueira Paranagua; DEGUTI, Marta; HORVAT, Natally; CANCADO, Eduardo Luiz Rachid; CARRILHO, Flair Jose; CHAGAS, Aline Lopes; TERRABUIO, Debora