PEDRO FRANCISCO GIAVINA-BIANCHI JUNIOR
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina - Líder
16 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 16
conferenceObject Esophagogastroduodenal Mucosal Behavior after Bronchial Challenge with House Dust Mites in Allergic Asthmatic Patients(2015) AGONDI, Rosana C.; NAVARRO-RODRIGUEZ, Tomas; BARBUTI, Ricardo; BISACCIONI, Carla; AUN, Marcelo Vivolo; KALIL, Jorge; GIAVINA-BIANCHI, PedroconferenceObject Bordetella Pertussis Whole-Cell Vaccine Inhibits Specific IgE, Inflammation and Airway Remodeling in a Murine Model of Asthma(2015) AUN, Marcelo Vivolo; ARANTES-COSTA, Fernanda; SARAIVA-ROMANHOLO, Beatriz Mangueira; ALMEIDA, Francine Maria; REGINA-BRUEGGERMANN, Thayse; MARTINS, Milton Arruda; KALIL, Jorge; GIAVINA-BIANCHI, Pedro- Defining phenotypes in rhinitis: A step toward personalized medicine(2015) GIAVINA-BIANCHI, Pedro
conferenceObject Basophil Activation Test As a Biomarker in Allergic Patients to Platins Undergoing Rapid Desensitization(2015) GIAVINA-BIANCHI, Pedro; GALVAO, Violeta; CAIADO, Joana; PICARD, Matthieu; CASTELLS, Mariana C.bookPart Terapêutica Monoclonal nas Doenças Alérgicas(2015) AGONDI, Rosana Câmara; GIAVINA-BIANCHI, Pedro; KALIL, JorgebookPart Alergia ao Látex(2015) GARRO, Laila Sabino; GALVãO, Violeta Régnier; GIAVINA-BIANCHI, Pedro- Aerobic training decreases bronchial hyperresponsiveness and systemic inflammation in patients with moderate or severe asthma: a randomised controlled trial(2015) FRANCA-PINTO, Andrezza; MENDES, Felipe A. R.; CARVALHO-PINTO, Regina Maria de; AGONDI, Rosana Camara; CUKIER, Alberto; STELMACH, Rafael; SARAIVA-ROMANHOLO, Beatriz M.; KALIL, Jorge; MARTINS, Milton A.; GIAVINA-BIANCHI, Pedro; CARVALHO, Celso R. F.Background The benefits of aerobic training for the main features of asthma, such as bronchial hyperresponsiveness (BHR) and inflammation, are poorly understood. We investigated the effects of aerobic training on BHR (primary outcome), serum inflammatory cytokines (secondary outcome), clinical control and asthma quality of life (Asthma Quality of Life Questionnaire (AQLQ)) (tertiary outcomes). Methods Fifty-eight patients were randomly assigned to either the control group (CG) or the aerobic training group (TG). Patients in the CG (educational programme+breathing exercises (sham)) and the TG (same as the CG+aerobic training) were followed for 3 months. BHR, serum cytokine, clinical control, AQLQ, induced sputum and fractional exhaled nitric oxide (FeNO) were evaluated before and after the intervention. Results After 12 weeks, 43 patients (21 CG/22 TG) completed the study and were analysed. The TG improved in BHR by 1 doubling dose (dd) (95% CI 0.3 to 1.7 dd), and they experienced reduced interleukin 6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1) and improved AQLQ and asthma exacerbation (p<0.05). No effects were seen for IL-5, IL-8, IL-10, sputum cellularity, FeNO or Asthma Control Questionnaire 7 (ACQ-7; p>0.05). A within-group difference was found in the ACQ-6 for patients with non-well-controlled asthma and in sputum eosinophil and FeNO in patients in the TG who had worse airway inflammation. Conclusions Aerobic training reduced BHR and serum proinflammatory cytokines and improved quality of life and asthma exacerbation in patients with moderate or severe asthma. These results suggest that adding exercise as an adjunct therapy to pharmacological treatment could improve the main features of asthma.
- Sensitization by subcutaneous route is superior to intraperitoneal route in induction of asthma by house dust mite in a murine mode(2015) AUN, Marcelo Vivolo; SARAIVA-ROMANHOLO, Beatriz Mangueira; ALMEIDA, Francine Maria de; BRüGGEMANN, Thayse Regina; KALIL, Jorge; MARTINS, Milton de Arruda; ARANTES-COSTA, Fernanda Magalhães; GIAVINA-BIANCHI, PedroABSTRACT Objective To develop a new experimental model of chronic allergic pulmonary disease induced by house dust mite, with marked production of specific immunoglobulin E (IgE), eosinophilic inflammatory infiltrate in the airways and remodeling, comparing two different routes of sensitization. Methods The protocol lasted 30 days. BALB/c mice were divided into six groups and were sensitized subcutaneously or intraperitoneally with saline (negative control), Dermatophagoides pteronyssinus (Der p) 50 or 500mcg in three injections. Subsequently they underwent intranasal challenge with Der p or saline for 7 days and were sacrificed 24 hours after the last challenge. We evaluated the titration of specific IgE anti-Der p, eosinophilic density in peribronchovascular space and airway remodeling. Results Both animals sensitized intraperitoneally and subcutaneously produced specific IgE anti-Der p. Peribronchovascular eosinophilia increased only in mice receiving lower doses of Der p. However, only the group sensitized with Der p 50mcg through subcutaneously route showed significant airway remodeling. Conclusion In this murine model of asthma, both pathways of sensitization led to the production of specific IgE and eosinophilia in the airways. However, only the subcutaneously route was able to induce remodeling. Furthermore, lower doses of Der p used in sensitization were better than higher ones, suggesting immune tolerance. Further studies are required to evaluate the efficacy of this model in the development of bronchial hyperresponsiveness, but it can already be replicated in experiments to create new therapeutic drugs or immunotherapeutic strategies.
conferenceObject Hereditary angioedema with normal C1 inhibitor: prevalence, clinical features and treatment of patients in a University Hospital in Brazil(2015) V, M. Arun; LONGEN, E.; PORTILHO, N. C.; AGONDI, R. C.; KALIL, J.; MOTTA, A. A.; GIAVINA-BIANCHI, P.conferenceObject Elevated Serum Tryptase Levels during Rituximab Hypersensitivity Reaction(2015) GIANNETTI, Matthew P.; PICARD, Matthieu; BADAWI, Cristina; BALEMA, Wintana; GIAVINA-BIANCHI, Pedro; CASTELLS, Mariana C.