VICTOR SARLI ISSA
Projetos de Pesquisa
Unidades Organizacionais
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
10 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 10
conferenceObject Prevalence of Cognitive Impairment in Heart Transplant Waiting-List Patients in a Developing Country(2020) OLIVEIRA, F. M. de; IKEDA, E. T.; AVILA, M.; WOZNIAK, I.; SEGURO, L.; SANTOS, M.; FELTRIM, M.; BARONE, F.; ISSA, V.; LAGE, S.; BACAL, F.; BOCCHI, E.; GAIOTTO, F.; NOMURA, C.; MARCONDES-BRAGA, F.; MANGINI, S.- Morphologic and immunohistochemical features of pulmonary vasculopathy in end-stage left ventricular systolic failure(2018) CAMPOS, Pompeu Tome Ribeiro de; LOPES, Antonio Augusto; ISSA, Victor Sali; AIELLO, Vera Demarchi
- Exercise training improves ambulatory blood pressure but not arterial stiffness in heart transplant recipients(2015) PASCOALINO, Lucas Nobilo; CIOLAC, Emmanuel Gomes; TAVARES, Aline Cristina; CASTRO, Rafael Ertner; AYUB-FERREIRA, Silvia Moreira; BACAL, Fernando; ISSA, Victor Sarli; BOCCHI, Edimar Alcides; GUIMARAES, Guilherme VeigaBACKGROUND: Hypertension is the most prevalent comorbidity after heart transplantation (HT). Exercise training (ET) is widely recommended as a key non-pharmacologic intervention for the prevention and management of hypertension, but its effects on ambulatory blood pressure (ABP) and some mechanisms involved in the pathophysiology of hypertension have not been studied in this population. The primary purpose of this study was to investigate the effects of ET on ABP and arterial stiffness of HT recipients. METHODS: 40 HT patients, randomized to ET (n = 31) or a control group (n = 9) underwent a maximal graded exercise test, 24-hour ABP monitoring, and carotid-femoral pulse wave velocity (PWV) assessment before the intervention and at a 12-week follow-up assessment. The ET program was performed thrice-weekly and consisted primarily of endurance exercise (40 minutes) at similar to 70% of maximum oxygen uptake (Vo(2MAX)) RESULTS: The ET group had reduced 24-hour (4.0 +/- 1.4 mm Hg, p < 0.01) and daytime (4.8 +/- 1.6 mm Hg, p < 0.01) systolic ABP, and 24-hour (7.0 +/- 1.4 mm Hg, p < 0.001) daytime (7.5 +/- 1.6 mm Hg, p < 0.001) and nighttime (5.9 +/- 1.5 mm Hg, p < 0.001) diastolic ABP after the intervention. The ET group also had improved Vo(2MAX) (9.7% +/- 2.6%, p < 0.001) after the intervention. However, PWV did not change after ET. No variable was changed in the control group after the intervention. CONCLUSIONS: The 12-week ET program was effective for reducing ABP but not PWV in heart transplant recipients. This result suggesfs that endurance ET may be a tool to counteract hypertension in this high-risk population.
conferenceObject Nutritional Characteristics of Patient with Chagas Cardiomyopathy with Decompensated Heart Failure(2017) TAVARES, L. C.; MOREIRA, H. F.; TERHOCH, C. B.; LAGE, S. H.; OLIVEIRA JUNIOR, M. T.; BOCCHI, E. A.; ISSA, V. S.conferenceObject Prevalence of Cognitive Impairment in Heart Transplant Waiting List Patients in a Developing Country(2021) OLIVEIRA, F. M. de; IKEDA, E. T.; AVILA, M. S.; CAMPOS, I. W.; SEGURO, L. F.; SANTOS, M. V.; FELTRIM, M.; BARONE, F.; ISSA, V. S.; LAGE, S.; BOCCHI, E. A.; GAIOTTO, F. A.; NOMURA, C.; BACAL, F.; MARCONDES-BRAGA, F. G.; MANGINI, S.conferenceObject Therapeutical Implications of Clinical Characteristics of Patients With Chagas Cardiomyopathy and Decompensated Heart Failure(2015) ISSA, V. S.; LIMA, G. C.; AYUB-FERREIRA, S. M.; LAGE, S. G.; OLIVEIRA JR., M. T.; NICOLAU, J.; BOCCHI, E. A.- Control of sinus tachycardia as an additional therapy in patients with decompensated heart failure (CONSTATHE-DHF): A randomized, double-blind, placebo-controlled trial(2016) LOFRANO-ALVES, Marco Stephan; ISSA, Victor Sarli; BISELLI, Bruno; CHIZZOLA, Paulo; AYUB-FERREIRA, Silvia Moreira; BOCCHI, Edimar Alcides
conferenceObject Control of Sinus Node Tachycardia as Additional Therapy in Patients With Decompensated Heart Failure (CONSTATHE)(2015) LOFRANO-ALVES, M. S.; ISSA, V. S.; BOCCHI, E. A.- Exhaled Acetone as a New Biomarker of Heart Failure Severity(2012) MARCONDES-BRAGA, Fabiana G.; GUTZ, Ivano G. R.; BATISTA, Guilherme L.; SALDIVA, Paulo H. N.; AYUB-FERREIRA, Silvia M.; ISSA, Victor S.; MANGINI, Sandrigo; BOCCHI, Edimar A.; BACAL, FernandoBackground: Heart failure (HF) is associated with poor prognosis, and the identification of biomarkers of its severity could help in its treatment. In a pilot study, we observed high levels of acetone in the exhaled breath of patients with HF. The present study was designed to evaluate exhaled acetone as a biomarker of HF diagnosis and HF severity. Methods: Of 235 patients with systolic dysfunction evaluated between May 2009 and September 2010, 89 patients (HF group) fulfilled inclusion criteria and were compared with sex- and age-matched healthy subjects (control group, n = 20). Patients with HF were grouped according to clinical stability (acute decompensated HF [ADHF], n = 59; chronic HF, n = 30) and submitted to exhaled breath collection. Identification of chemical species was done by gas chromatography-mass spectrometry and quantification by spectrophotometry. Patients with diabetes were excluded. Results: The concentration of exhaled breath acetone (EBA) was higher in the HF group (median, 3.7 mu g/L; interquartile range [IQR], 1.69-10.45 mu g/L) than in the control group (median, 0.39 mu g/L; IQR, 0.30-0.79 mu g/L; P < .001) and higher in the ADHF group (median, 7.8 mu g/L; IQR, 3.6-15.2 mu g/L) than in the chronic HF group (median, 1.22 mu g/L; IQR, 0.68-2.19 P < .001). The accuracy and sensitivity of this method in the diagnosis of HF and ADHF were about 85%, a value similar to that obtained with B-type natriuretic peptide (BNP). EBA levels differed significantly as a function of severity of HF (New York Heart Association classification, P < .001). There was a positive correlation between EBA and BNP (r = 0.772, P < .001). Conclusions: EBA not only is a promising noninvasive diagnostic method of HF with an accuracy equivalent to BNP but also a new biomarker of HF severity. CHEST 2012; 142(2):457-466
conferenceObject Immunohistochemical Counting of Mononuclear Infiltrates in Endomyocardial Biopsy Fragments: A New Method To Improve the Diagnosis of Rejection after Heart Transplantation(2013) BOCCHI, E. A.; BENVENUTTI, L. A.; TANIGAWA, R.; BRANDAO, S.; ISSA, V. S.; AYUB-FERREIRA, S.; CRUZ, F.; POMERANTZEFF, P.; HONORATO, R.; LOURENCO-FILHO, D. D.; FIORELLI, A. I.; CHIZZOLA, P.; SOUZA, G.; BACAL, F.