BRUNO GUALANO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina - Líder
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- Is Open-Label Placebo a New Ergogenic Aid? A Commentary on Existing Studies and Guidelines for Future Research(2020) SAITO, Tiemi; BARRETO, Gabriel; SAUNDERS, Bryan; GUALANO, BrunoThe placebo effect has been defined as a genuine psychobiological response that arises from the belief that a positive intervention has been received. However, the notion that belief in an active treatment is necessary to elicit a placebo effect has been challenged. Recent data show that placebo effects may occur even when individuals are openly informed that they are receiving an inert treatment, the so-called open-label placebo. In fact, clinical studies have shown improvements in disease symptoms in patients who underwent an open-label placebo intervention. Now, the application of open-label placebo is attracting interest among the sports science community. Open-label placebo could be a useful and ethically permitted tool to improve exercise performance when applied in combination with other legal ergogenic aids (e.g., nutritional supplements) and/or in place of illegal substances (e.g., anabolic steroids). However, independent laboratories recently investigated the effects of open-label placebo on exercise performance with contrasting results, suggesting that there is much more research required before widespread implementation of open-label placebo in the field of sport and exercise can be justified. Herein we discuss the emerging science on open-label placebo interventions from a clinical setting to sports science. Moreover, we propose a research agenda for investigations on open-label placebo in sports and exercise sciences by covering the main gaps in the field. Addressing the research agenda put forward will help to advance our understanding of this intriguing topic.
conferenceObject Sex, But Not Age, Associates With Whole Muscle Carnosine Content Of Trained Men And Women(2020) DOLAN, Eimear; SWINTON, Paul A.; OLIVEIRA, Luana Farias de; REZENDE, Nathalia Saffioti; MAZZOLANI, Bruna Caruso; BESTETTI, Giulia Cazetta; SMAIRA, Fabiana Infante; DUMAS, Alina; PERIM, Pedro; RIANI, Luiz; GUALANO, Bruno; SAUNDERS, Bryan- 24-Week beta-alanine ingestion does not affect muscle taurine or clinical blood parameters in healthy males(2020) SAUNDERS, Bryan; FRANCHI, Mariana; OLIVEIRA, Luana Farias de; SILVA, Vinicius da Eira; SILVA, Rafael Pires da; PAINELLI, Vitor de Salles; COSTA, Luiz Augusto Riani; SALE, Craig; HARRIS, Roger Charles; ROSCHEL, Hamilton; ARTIOLI, Guilherme Giannini; GUALANO, BrunoPurpose To investigate the effects of chronic beta-alanine (BA) supplementation on muscle taurine content, blood clinical markers and sensory side-effects. Methods Twenty-five healthy male participants (age 27 +/- 4 years, height 1.75 +/- 0.09 m, body mass 78.9 +/- 11.7 kg) were supplemented with 6.4 g day(-1) of sustained-release BA (N = 16; CarnoSyn (TM), NAI, USA) or placebo (PL; N = 9; maltodextrin) for 24 weeks. Resting muscle biopsies of the m. vastus lateralis were taken at 0, 12 and 24 weeks and analysed for taurine content (BA, N = 12; PL, N = 6) using high-performance liquid chromatography. Resting venous blood samples were taken every 4 weeks and analysed for markers of renal, hepatic and muscle function (BA, N = 15; PL, N = 8; aspartate transaminase; alanine aminotransferase; alkaline phosphatase; lactate dehydrogenase; albumin; globulin; creatinine; estimated glomerular filtration rate and creatine kinase). Results There was a significant main effect of group (p = 0.04) on muscle taurine, with overall lower values in PL, although there was no main effect of time or interaction effect (both p > 0.05) and no differences between specific timepoints (week 0, BA: 33.67 +/- 8.18 mmol kg(-1) dm, PL: 27.75 +/- 4.86 mmol kg(-1) dm; week 12, BA: 35.93 +/- 8.79 mmol kg(-1) dm, PL: 27.67 +/- 4.75 mmol kg(-1) dm; week 24, BA: 35.42 +/- 6.16 mmol kg(-1) dm, PL: 31.99 +/- 5.60 mmol kg(-1) dm). There was no effect of treatment, time or any interaction effects on any blood marker (all p > 0.05) and no self-reported side-effects in these participants throughout the study. Conclusions The current study showed that 24 weeks of BA supplementation at 6.4 g day(-1) did not significantly affect muscle taurine content, clinical markers of renal, hepatic and muscle function, nor did it result in chronic sensory side-effects, in healthy individuals. Since athletes are likely to engage in chronic supplementation, these data provide important evidence to suggest that supplementation with BA at these doses for up to 24 weeks is safe for healthy individuals.
- Infographic. A systematic review and meta-analysis of the effect of beta-alanine supplementation on exercise capacity and performance(2020) SAUNDERS, Bryan; VIRGILE, Adam; ELLIOTT-SALE, Kirsty Jayne; ARTIOLI, Guilherme Giannini; SWINTON, Paul A.; DOLAN, Eimear; ROSCHEL, Hamilton; SALE, Craig; GUALANO, Bruno
- Is Open-Label Placebo a New Ergogenic Aid? A Commentary on Existing Studies and Guidelines for Future Research (vol 33, pg 543, 2020)(2020) SAITO, Tiemi; BARRETO, Gabriel; SAUNDERS, Bryan; GUALANO, Bruno