BRUNO GUALANO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina - Líder
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- A single session of aerobic exercise reduces systolic blood pressure at rest and in response to stress in women with rheumatoid arthritis and hypertension(2024) LUNA, Tatiane Almeida de; REZENDE, Diego Augusto Nunes; BRITO, Leandro Campos de; FECCHIO, Rafael Yokoyama; LIMA, Fernanda Rodrigues; PINTO, Ana Lucia de Sa; RIBEIRO, Ana Cristina de Medeiros; BONFIGLIOLI, Karina Rossi; GUALANO, Bruno; ROSCHEL, Hamilton; PECANHA, TiagoRheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by increased risk of cardiovascular disease and hypertension (HT). A single session of aerobic exercise may reduce blood pressure (BP) in different clinical groups; however, little is known about the acute effects of exercise on BP in RA patients. This is a randomized controlled crossover study that assessed the effects of a single session of aerobic exercise on resting BP, on BP responses to stressful stimuli, and on 24-h BP in women with RA and HT. Twenty women with RA and HT (53 +/- 10 years) undertook sessions of 30-min treadmill exercise (50% VO2max) or control (no exercise) in a crossover fashion. Before and after the sessions, BP was measured at rest, and in response to the Stroop-Color Word Test (SCWT), the Cold Pressor Test (CPT), and an isometric handgrip test. After the sessions, participants were also fitted with an ambulatory BP monitor for the assessment of 24-h BP. A single session of exercise reduced resting systolic BP (SBP) (-5 +/- 9 mmHg; p < 0.05), and reduced SBP response to the SCWT (-7 +/- 14 mmHg; p < 0.05), and to the CPT (-5 +/- 11 mmHg; p < 0.05). Exercise did not reduce resting diastolic BP (DBP), BP responses to the isometric handgrip test or 24-h BP. In conclusion, a single session of aerobic exercise reduced SBP at rest and in response to stressful stimuli in hypertensive women with RA. These results support the use of exercise as a strategy for controlling HT and, hence, reducing cardiovascular risk in women with RA.
- Role of the exercise professional in metabolic and bariatric surgery(2024) STULTS-KOLEHMAINEN, Matthew A.; BOND, Dale S.; RICHARDSON, Laura A.; HERRING, Louisa Y.; MULONE, Bethany; GARBER, Carol Ewing; MORTON, John; GHIASSI, Saber; DUFFY, Andrew J.; BALK, Ethan; ABOLT, Charles J.; HOWARD, Matt C.; ASH, Garrett I.; WILLIAMSON, Susannah; MARCON, Emilian Rejane; SANTOS, Melissa De Los; BOND, Samantha; HUEHLS, Janet; ALOWAISH, Osama; HEYMAN, Nina Brojan; GUALANO, BrunoObjectives: To investigate: (1) who are the professionals implementing PA programming in MBS clinical settings; and (2) what patient-centric tasks do they perform? Setting: Clinical and academic exercise settings worldwide.Methods: This multimethod study included a scoping review of PA programs in MBS described in the research literature. Data about job tasks were extracted and provided to 10 experts to sort into categories. Cluster analysis was utilized to find the hierarchical structure of tasks. A Delphi process was used to agree on a final model.Results: The majority of PA professionals were exercise physiologists in the USA and physiotherapists or other types of exercise professionals elsewhere. Forty-three tasks were identified, the most reported being supervision of exercise, fitness testing, and exercise prescription. Seven higher-order categories were determined: (1) Exercise-related health assessment, (2) Body composition and physical fitness assessment, (3) Lifestyle physical activity and sedentary behavior assessment, (4) Education, instruction, and prescription, (5) Exercise monitoring, (6) Behavioral counseling and psychosocial support, and (7) Dietary support. The following statements were rated an average of 9.0, classifying them as ""imperative"": 1) ""Pre-and postoperative PA/exercise guidelines for MBS patients are needed"", 2) ""MBS programs need to include PA/exercise as part of multidisciplinary care"".Conclusions: The expert group reached a consensus on 7 major classifications of job tasks for the exercise professional. It is important for governing medical associations across the world to formally recognize experienced exercise professionals as playing pivotal roles in continuing, multidisciplinary care for MBS patients. These findings also provide evidence-based information in the effort to solidify these positions within the greater context of healthcare. (Surg Obes Relat Dis 2024;20:98-110.) (c) 2024 American Society for Metabolic and Bariatric Surgery.
- Higher resistance training volume offsets muscle hypertrophy nonresponsiveness in older individuals(2024) LIXANDRAO, Manoel E.; BAMMAN, Marcas; VECHIN, Felipe C.; CONCEICAO, Miguel S.; TELLES, Guilherme; LONGOBARDI, Igor; DAMAS, Felipe; LAVIN, Kaleen M.; DRUMMER, Devin J.; MCADAM, Jeremy S.; DUNGAN, Cory M.; LEITAO, Alice E.; COSTA, Luiz A. Riani; AIHARA, Andre Y.; LIBARDI, Cleiton A.; GUALANO, Bruno; ROSCHEL, HamiltonThe magnitude of muscle hypertrophy in response to resistance training (RT) is highly variable between individuals (response heterogeneity). Manipulations in RT variables may modulate RT-related response heterogeneity; yet, this remains to be determined. Using a within-subject unilateral design, we aimed to investigate the effects of RT volume manipulation on whole muscle hypertrophy [quadriceps muscle cross-sectional area (qCSA)] among nonresponders and responders to a low RT dose (single-set). We also investigated the effects of RT volume manipulation on muscle strength in these responsiveness groups. Eighty-five older individuals [41M/44F, age = 68 +/- 4 yr; body mass index (BMI) = 26.4 +/- 3.7 kg/m(2)] had one leg randomly allocated to a single (1)-set and the contralateral leg allocated to four sets of unilateral knee-extension RT at 8-15 repetition maximum (RM) for 10-wk 2 days/wk. Pre- and postintervention, participants underwent magnetic resonance imaging (MRI) and unilateral knee-extension 1-RM strength testing. MRI typical error (2x TE = 3.27%) was used to classify individuals according to responsiveness patterns. n = 51 were classified as nonresponders (<= 2x TE) and n = 34 as responders (>2x TE) based on pre- to postintervention change qCSA following the single-set RT protocol. Nonresponders to single-set training showed a dose response, with significant time x set interactions for qCSA and 1-RM strength, indicating greater gains in response to the higher volume prescription (time x set: P < 0.05 for both outcomes). Responders improved qCSA (time: P < 0.001), with a tendency toward higher benefit from the four sets RT protocol (time x set: P = 0.08); on the other hand, 1-RM increased similarly irrespectively of RT volume prescription (time x set: P > 0.05). Our findings support the use of higher RT volume to mitigate nonresponsiveness among older adults.
- Acute and short-term beetroot juice nitrate-rich ingestion enhances cardiovascular responses following aerobic exercise in postmenopausal women with arterial hypertension: A triple-blinded randomized controlled trial(2024) BENJAMIM, Cicero Jonas R.; SILVA, Leonardo Santos L. da; SOUSA, Yaritza B. Alves; RODRIGUES, Guilherme da Silva; PONTES, Yasmim M. de Moraes; REBELO, Macario Arosti; GONSALVES, Leonardo da Silva; TAVARES, Simone Sakagute; GUIMARA, Carolina S.; SOBRINHO, Andressa C. da Silva; TANUS-SANTOS, Jose E.; GUALANO, Bruno; BUENO, Carlos R.Background: The increase in blood pressure (BP) levels in the postmenopausal period can be partly explained by the decrease in nitric oxide synthases (NOS). Objective: To investigate the acute and one-week effects of beetroot juice nitrate-rich (BRJ-NO3-rich) ingestion on cardiovascular and autonomic performance in response to submaximal aerobic exercise in postmenopausal women with systemic arterial hypertension (SAH) who are physically inactive. Methods: Fourteen postmenopausal women with SAH [mean (SD) age: 59(4) y; BMI (kg/m2): 29.2(3.1)] completed submaximal aerobic exercise bouts after an acute and a one-week intervention with BRJ in a placebocontrolled, randomized, triple-blind, crossover design. Participants ingested either BRJ (800 mg of NO3- ) or placebo acutely and drank either BRJ (400 mg of NO3- ) or placebo every day for the next six days. After two and 1/2 hours, they performed a session of aerobic submaximal aerobic exercise, and their systolic BP (SBP) and diastolic BP (DBP), flow-mediated dilation (FMD), heart rate (HR) recovery, and HR variability were measured. Results: In the post-exercise recovery period, SBP dropped significantly in the BRJ-NO3- rich group (-9.28 mmHg [95%CI: -1.68 to -16.88] ES: -0.65, p = 0.019) compared to placebo after acute ingestion. The FMD values increased after acute BRJ-NO3-rich on post-exercise (3.18 % [0.36 to 5.99] ES: 0.87, p = 0.031). After the oneweek intervention, FMD values were higher in the BRJ-NO3- rich group before (4.5 % [1.62 to 7.37] ES: 1.21, p = 0.005) and post-exercise measurements (4.2 % [1.52 to 6.87] ES: 1.22, p = 0.004) vs. placebo. HRV indices with remarkable parasympathetic modulation to heart recovered faster on the BRJ-NO3-rich group than placebo group. No between-group differences were identified in values of HR post-exercise recovery in the 30s, 60s, 120s, 180s, and 300s. Conclusions: Acute and short-term BRJ-NO3-rich ingestion may enhance cardiovascular and autonomic behavior in response to aerobic exercise in postmenopausal women diagnosed with SAH. Clinical trial registry number: https://clinicaltrials.gov/ct2/show/NCT05384340.