RICARDO DOS SANTOS SIMOES

(Fonte: Lattes)
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Lattes
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Instituto Central, Hospital das Clínicas, Faculdade de Medicina
SCGINEC-62, Hospital Universitário
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina

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  • article 7 Citação(ões) na Scopus
    The effects of soybean isoflavones and 17-estradiol in uterus and mammary glands of diabetic rat models
    (2018) CARBONEL, Adriana Aparecida Ferraz; LIMA, Patricia Daniele Azevedo; LIM, Jung Jin; FUCHS, Luiz Fernando Portugal; PAIOTTI, Ana Paula Ribeiro; SASSO, Gisela Rodrigues da Silva; SIMOES, Ricardo Santos; SOARES JUNIOR, Jose Maria; BARACAT, Edmund Chada; SIMOES, Manuel de Jesus
    The objective of this study was to evaluate the action of soy isoflavones and 17 beta estradiol on the extracellular matrix in the uterus and mammary gland of diabetic rats. Sixty adult female rats underwent ovariectomy, then randomized into seven groups of ten animals each: Non-diabetic: GI Sham control animals ovariectomized; and GII control ovariectomized that received propylene glycol vehicle. Diabetic: GIII Sham control diabetic animals ovariectomized; GIV ovariectomized diabetic animals receiving propylene glycol vehicle; GV diabetic ovariectomized animals treated with soy isoflavones (150mg/kg by gavage); GVI ovariectomized diabetic rats treated with estrogen (17b-estradiol, 10mg/kg, subcutaneously); GVII diabetic ovariectomized animals treated with soy isoflavones (150 mg/kg by gavage), and with estrogen (17b-estradiol, 10 mg/kg combination therapy). Treatments occurred during 30 consecutive days. After animals euthanasia, a portion of the uterus was immersed in liquid nitrogen for molecular biology analysis, the other portion of uterus and mammary glands were removed and processed for paraffin embedding. Soy isoflavones (GV) and 17b estradiol improved the production of compounds of extracellular matrix, such as small leucine-rich proteoglycans (SLRPs). The combination of both therapies had an additive effect in SLRPs expression. Soy isoflavones contribute to the uterine integrity of SLRPs of diabetic rats.