RICARDO DOS SANTOS SIMOES
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
SCGINEC-62, Hospital Universitário
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
SCGINEC-62, Hospital Universitário
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
18 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 18
bookPart Câncer de ovário: tumores epiteliais(2016) CARVALHO, Jesus Paula; SIMõES, Ricardo dos Santos; BARACAT, Edmund ChadaconferenceObject Elevation of collagen and proteoglycan in diabetic rat vaginas treated with soybean isoflavones, 17 beta-estradiol and combined therapy(2016) CARBONEL, Adriana A.; SIMOES, Ricardo Santos; BERTONCINI, Clelia R.; SOARES JR., Jose M.; SIMOES, Manuel J.bookPart Pólipos endometriais(2016) PEREIRA, Anne Kristhine Cavalcante; PINHEIRO, Walter; SIMõES, Ricardo dos Santos; JúNIOR, José Maria Soares; BARACAT, Edmund ChadabookPart Sangramento uterino anormal na vigência de terapia hormonal na pós-menopausa(2016) JúNIOR, José Maria Soares; SORPRESO, Isabel Cristina Esposito; SIMõES, Ricardo dos Santos; BARACAT, Maria Cândida Pinheiro; BARACAT, Edmund ChadaconferenceObject Gene expression of small leucine-rich proteoglycans (SLRPS) in lacrimal gland of female mice with hyperprolactinemia induced metoclopramide(2016) STAVARE, Ariadne; VERNA, Carina; SIMOES, Ricardo; NADER, Helena; SOARES- JR., Jose; BARACAT, Edmund; GOMES, ReginabookPart Câncer de endométrico: diagnóstico(2016) CARVALHO, Jesus Paula; ANTON, Cristina; SIMõES, Ricardo dos Santos; BARACAT, Edmund ChadabookPart Câncer de ovário: tumores de células germinativas, cordão sexual e estroma(2016) CARVALHO, Jesus Paula; SIMõES, Ricardo dos Santos; BARACAT, Edmund ChadabookPart Fito-hormônios na pós-menopausa(2016) JúNIOR, José Maria Soares; BARACAT, Maria Cândida Pinheiro; SIMõES, Ricardo dos Santos; SORPRESO, Isabel Cristina Esposito; BARACAT, Edmund ChadabookPart Câncer de ovário: rastreamento(2016) CARVALHO, Jesus Paula; SIMõES, Ricardo dos Santos; BARACAT, Edmund Chada- Effects of hyperprolactinemia on the tibial epiphyseal plate of mice treated with sex hormones(2016) WOLFF, Roberta B.; GOMES, Regina Celia T.; AMARAL, Vinicius C. do; SILVA, Priscilla L. da; SIMONCINI, Tommaso; PROSDOCIMI, Fabio Cesar; SIMOES, Ricardo S.; SIMOES, Manuel Jesus S.; BARACAT, Edmund C.; SOARES JR., Jose MariaThe aim of this study was to evaluate the effects of metoclopramide-induced hyperprolactinemia on the tibial epiphyseal plate of hormone-treated oophorectomized mice. For this purpose, 18 animals with intact ovaries were allocated to two groups, M (metoclopramide) and V (vehicle). One hundred and eight oophorectomized animals were allocated to 12 subgroups: Oophx/V (vehicle); Ooph/M (metoclopramide); Oophx/V+E (vehicle+estradiol); Oophx/M+E (metoclopramide+estradiol); Oophx/V+P (vehicle+progesterone); Oophx/M+P (metoclopramide+progesterone); Oophx/V+T (vehicle+testosterone); Oophx/M+T (metoclopramide+testosterone); Oophx/V+E+P (Vehicle+estradiol+progesterone); Oophx/M+E+P (metoclopramide+estradiol+progesterone); Oophx/V+E+P+T (vehicle+estradiol+progesterone+testosterone); Oophx/M+E+P+T (metoclopramide+estradiol+progesterone+testosterone). After a 50-day treatment was performed histomorphometric and immunohistochemical cell death analysis. In the epiphyseal plate of the hyperprolactinemic and/or oophorectomized animals, cell proliferation and bone formation decreased, inducing intensified cell death. In the sex steroid-treated animals, estrogen boosted cell proliferation; progesterone, bone formation and testosterone, both cell proliferation and bone formation. These findings suggest that oophorectomy and hyperprolactinemia changed epiphyseal plate morphology causing cartilage degeneration. Treatment with combined sex steroids may diminish such deleterious effects.