JACOB JEHUDA FAINTUCH
Índice h a partir de 2011
4
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
6 resultados
Resultados de Busca
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- Precision medicine: The microbiome and metabolome(2019) FAINTUCH, J.; FAINTUCH, J. J.The microbiome gap, between just data accumulation and theoretical speculations from one side and clinical benefits to the patient from the other, is being rapidly filled. The microbiome is a crucial facet of the individual response to inflammation, cancer, metabolic and degenerative diseases, immunological conditions, neuropsychiatric pathology, diet, xenobiotic processing, surgical interventions, and even environmental stress. With the determination of key microorganisms, enzymes, metabolites, and pathways, advances are rapidly accumulating. Multilayer diagnostic and therapeutical algorithms, bedside microbiomics and metabolomics, new-generation probiotics and postbiotics, phage therapy, and patient-specific fecal transplantation are the foundations of the new era. It is not a distant vision anymore. Many applications are real and ready for clinical use. © 2019 Elsevier Inc. All rights reserved.
- Microbiome and metabolome glossary(2019) FAINTUCH, J.; FAINTUCH, J. J.
- Precision medicine glossary(2019) FAINTUCH, J.; FAINTUCH, J. J.The study of the multiple disciplines involved in Precision Medicine has expanded so rapidly that the vocabulary was sometimes unable to catch up. Of course, Genetics, Genomics, Metabolomics, Proteomics, Molecular Biology, and an array of related areas were extraordinarily helpful, lending not only tools and techniques but also the essential glossary. Nevertheless, neologisms are indispensable, with the inherent criticisms and conflicts, which such words entail. A basic glossary is here presented, aiming to unify a variety of concepts and contexts. A table with helpful internet sites is added as well. © 2020 Elsevier Inc. All rights reserved.
- Systemic inflammation and carotid diameter in obese patients: pilot comparative study with flaxseed powder and cassava powder(2011) FAINTUCH, J.; BORTOLOTTO, L. A.; MARQUES, P. C.; FAINTUCH, J. J.; FRANCA, J. I.; CECCONELLO, I.Background: Botanical omega-3 fatty acid (alpha-linolenic acid/ALA) has been shown to alleviate the prothrombotic and proinflammatory profile of metabolic syndrome, however clinical protocols are still scarce. Aiming to focus an obese population, a pilot study was designed. Methods: Morbidly obese candidates for bariatric surgery (n = 29, age 463 +/- 5.2 years), 82.8% females (24/29), BMI 44.9 +/- 5.2 kg/m(2), with C-reactive protein/CRP > 5 mg/L were recruited. Twenty were randomized and after exclusions, 16 were available for analysis. Flaxseed powder (60 g/day, 10 g ALA) and isocaloric roasted cassava powder (60 g/day, fat-free) were administered in a double-blind routine for 12 weeks. Results: During flaxseed consumption neutrophil count decreased and fibrinogen, complement C4, prothrombin time and carotid diameter remained stable, whereas placebo (cassava powder) was associated with further elevation of those measurements. Conclusions: Inflammatory and coagulatory markers tended to exhibit a better outlook in the flaxseed group. Also large-artery diameter stabilized whereas further increase was noticed in controls. These findings raise the hypothesis of a less deleterious cardiovascular course in seriously obese subjects receiving a flaxseed supplement. (Nutr Hosp. 2011;26:208-213) DOI:10.3305/nh.2011.26.1.4974
- Useful Online Resources and Guideline(2022) FAINTUCH, J.; FAINTUCH, J. J.The Internet has become such an omnipresent service, that in the view of many, it has already upgraded from slave to master, and quite a tyrannical one. Whatever the feelings, scientific information would not flow worldwide without the tool, in such unlimited amounts. It is currently estimated that 4.7 billion people use its electronic resources (60% of the planet population). Just the four big names in the field (Google, Amazon, Microsoft and Facebook) store a total of 1200 petabytes of files, each petabyte corresponding to 1015 bytes. If it corresponded to text, only that would represent over 670 billion pages. The MEDLINE database is a more pertinent paradigm as it deals with indexed scientific journals. Other publications such as books, theses, congress proceedings, nonindexed journals, court minutes and press reports are with few exceptions uncovered. It still contains close to 30 million articles or over 300 million pages. Given that a human being rarely reads more than 700 pages/week (a reasonably thick book), that would signal over 8000 millennia to peruse such files, if all of them were available online. These ruminations could look rather aimless and out of focus, yet they point towards the incontrovertible need for careful curation of the key Internet addresses, so that the interested researcher will minimize wasted time and likely find helpful material. That is the objective of the chapter listing a choice of useful sites as well as general Internet resources, nearly all of them costless. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
- Useful internet sites(2019) FAINTUCH, J.; FAINTUCH, J. J.Internet reference sites for genome sequencing, microbiomics, metabolomics, transcriptomics, proteomics, bioinformatics, and other topics are provided. Some of them are layered, offering data banks and processing tools in multiple domains. Thus, the current stratification is just an initial guideline. Sites should be searched, as additions and updates, as well as occasional closures, are constantly occurring. © 2020 Elsevier Inc. All rights reserved.