SILVIA VANESSA LOURENCO
Projetos de Pesquisa
Unidades Organizacionais
ODE, FO - Docente
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina - Líder
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- In vivo confocal microscopy of dermoscopic suspicious lesions in patients with xeroderma pigmentosum: A cross-sectional study(2020) ROCHA, Lilian; FERREIRA, Paula Silva; AVANCINI, Joao; LOURENCO, Silvia; BARBOSA, Caroline de Freitas; COLACIQUE, Caroline; FESTA-NETO, CyroBackground: Xeroderma pigmentosum (XP) is a rare genetic disease characterized by extreme photosensitivity, resulting in a higher incidence of cutaneous tumors. Reflectance confocal microscopy (RCM) is a noninvasive imaging method for diagnosing cutaneous lesions. Objective: To explore the application of RCM in the follow-up of patients with XP. Methods: Patients with XP underwent RCM for suspicious lesions from January 2010 through April 2019. Lesions with malignant RCM features were excised, and the results were compared with their histopathologic features. Benign lesions on RCM were monitored every 3 months. We recorded the confocal features that were related to malignancy and specifically to melanoma. Results: A total of 61 suspicious lesions from 13 patients with XP were included. Thirty-three lesions (54%) were malignant (14 melanomas, 15 basal cell carcinomas, and 4 squamous cell carcinomas). Nonvisible papillae (OR, 11.8; 95% CI, 2.6-53.1; P = .001) and atypical cells at the dermoepidermal junction (OR, 11.7; 95% CI, 2.7-50.3; P = .001) were independent predictors of malignancy. Limitations: There were limited numbers of patients and lesions. Most cases were retrospectively included, and some did not have a histologic analysis. Conclusions: RCM is a valuable tool in the follow-up of patients with XP, reducing the need for excisions by 35%.
article 8 Citação(ões) na Scopus Melanoma in Children, Adolescents, and Young Adults: A Clinical Pathological Study in a Brazilian Population(2014) SANCHEZ, Paula C. F.; NODA, Aliene Y. I.; FRANCO, Dilcilea D. G. S.; LOURENCO, Silvia V.; SANGUEZA, Martin; NETO, Cyro F.Malignant melanoma in children, adolescents, and young adults is unusual, especially before puberty. In children (age, 0-14 years), most primary lesions are thick and atypical (amelanotic, simulating pyogenic granuloma). In the population of adolescents and young adults (age, 15-39 years), melanoma is the third most common cancer, only behind lymphoma and breast cancer. Our study investigated the records of 89 patients diagnosed with cutaneous melanoma at age 0-39 years at Hospital das Cl nicas, Medical School, University of Sao Paulo between 1992 and 2002. They were divided into group A (0-14 years of age) and group B (15-39 years of age). The histopathology of all cases was reexamined. Statistical analysis of the data presented was performed, and the obtained data were compared with the literature. The frequency of melanoma in the group aged 15-39 years was higher in women, and the most affected site was the trunk. Additionally, melanomas were more frequent at an earlier age in patients with family history of melanoma (P = 0.014). Most cases were diagnosed, at histopathology, as superficial spreading melanoma. Thick nodular melanomas with Breslow values higher than 2 mm were associated with lymph node metastasis (P < 0.05). Our study revealed that melanoma in children, adolescents, and young adults may present peculiar behavior and outcome, which might reflect the genetic and yet not fully unraveled pathogenesis of this complex disease.- Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis(2017) CHAVES, Yuri N.; TOREZAN, Luis Antonio; LOURENCO, Silvia Vanessa; NETO, Cyro FestaIntroductionActinic cheilitis (AC) is a lip intraepithelial neoplasia, whose cells present alterations similar to those presented by invasive squamous cell carcinomas (SCCs). ObjectiveTo conduct clinical and laboratory evaluation by histopathology and immunohistochemistry of the efficacy of actinic cheilitis treatment using photodynamic therapy (PDT) with methyl aminolevulinate (MAL) and noncoherent red light. Materials and methodsPatients with actinic cheilitis detected by histopathological examination were submitted to two sessions of photodynamic therapy with a two-week interval between them. They were examined immediately after the sessions, four, six, and twelve weeks after beginning treatment when a new biopsy was carried out. Clinical histopathological and immunohistochemical parameters were evaluated before and after treatment. ResultsOf the 23 patients who underwent biopsy, 16 completed two photodynamic therapy sessions and the material of one patient was insufficient for immunohistochemistry. Complete clinical response was achieved in 62.5% (10 of 16 patients) and 37.5% still remained with clinical evidence of AC. In spite of this, no case of cure by histopathological analysis was found. There was no significant statistical change among the values of Ki-67, survivin, and p53 observed before and after treatment. ConclusionPhotodynamic therapy, as carried out in this trial, was not an efficacious therapeutic option for treating patients with actinic cheilitis included in this sample.
conferenceObject Melanoma in children, adolescents, and young adults: A clinicopathologic study in a Brazilian population(2014) NODA, Aliene; NETO, Cyro; FRANCO, Dilcilea; SANGUEEZA, Martin; SANCHEZ, Paula; LOURENCO, Silvia