MARIA LUCIA BUENO GARCIA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
8 resultados
Resultados de Busca
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- The association between air pollution and blood pressure in traffic controllers in Santo Andre, Sao Paulo, Brazil(2011) CHIARELLI, Paulo Sergio; PEREIRA, Luiz Alberto Amador; SALDIVA, Paulo Hilario do Nascimento; FERREIRA FILHO, Celso; GARCIA, Maria Lucia Bueno; BRAGA, Alfesio Luis Ferreira; MARTINS, Lourdes ConceicaoBackground: Urban air pollutants are associated with cardiovascular events. Traffic controllers are at high risk for pollution exposure during outdoor work shifts. Objective: The purpose of this study was to evaluate the relationship between air pollution and systemic blood pressure in traffic controllers during their work shifts. Methods: This cross-sectional study enrolled 19 male traffic controllers from Santo Andre city (Sao Paulo, Brazil) who were 30-60 years old and exposed to ambient air during outdoor work shifts. Systolic and diastolic blood pressure readings were measured every 15 min by an Ambulatory Arterial Blood Pressure Monitoring device. Hourly measurements (lags of 0-5 h) and the moving averages (2-5 h) of particulate matter (PM(10)), ozone (O(3)) ambient concentrations and the acquired daily minimum temperature and humidity means from the Sao Paulo State Environmental Agency were correlated with both systolic and diastolic blood pressures. Statistical methods included descriptive analysis and linear mixed effect models adjusted for temperature, humidity, work periods and time of day. Results: Interquartile increases of PM(10) (33 mu g/m(3)) and O(3) (49 mu g/m(3)) levels were associated with increases in all arterial pressure parameters, ranging from 1.06 to 2.53 mmHg. PM(10) concentration was associated with early effects (lag 0), mainly on systolic blood pressure. However, O(3) was weakly associated most consistently with diastolic blood pressure and with late cumulative effects. Conclusions: Santo Andre traffic controllers presented higher blood pressure readings while working their outdoor shifts during periods of exposure to ambient pollutant fluctuations. However, PM(10) and O(3) induced cardiovascular effects demonstrated different time courses and end-point behaviors and probably acted through different mechanisms.
conferenceObject Inflammation in traffic professional from Sao Paulo after pollutants emission control implementation(2012) GARCIA, Maria Lucia Bueno; MARTINS, Lourdes Conceicao; BRAGA, Alfesio; LEMOS, Miriam; PEREIRA, Luis; AFONSO, Paulo; SALDIVA, Paulo; UBIRATAN, Paula Santos- Association between Traffic Air Pollution and Reduced Forced Vital Capacity: A Study Using Personal Monitors for Outdoor Workers(2016) SANTOS, Ubiratan Paula; GARCIA, Maria Lucia Siqueira Bueno; BRAGA, Alfesio Luis Ferreira; PEREIRA, Luiz Alberto Amador; LIN, Chin An; ANDRE, Paulo Afonso de; ANDRE, Carmen Diva Saldiva de; SINGER, Julio da Motta; SALDIVA, Paulo Hilario NascimentoBackground The effects of outdoor air pollution on lung function in adults are still controversial. Objective Evaluate the effects of exposure to different levels of traffic-generated PM2.5 on workers' lung functions in Sao Paulo, Brazil. Methods To cover a wide range of exposures, 101 non-smoking workers from three occupations (taxi drivers, traffic controllers, and forest rangers) were selected for the study. After clinical evaluation, the participants were scheduled to attend four consecutive weekly visits in which they received a 24-hour personal PM2.5 sampler and had lung function tests measured on the following day. The association between the spirometric variables and the averaged PM2.5 levels was assessed using robust regression models adjusted for age, waist circumference, time at the job, daily work hours, diabetes or hypertension and former smoking habits. Results Relative to workers in the lowest exposed group (all measures <25 mu g/m(3)), those with the highest level of exposure (all measures >39.6 mu g/m(3)) showed a reduction of predicted FVC (-12.2%; CI 95%: [-20.0% to -4.4%]), a marginal reduction of predicted FEV1 (-9.1%; CI 95%: [-19.1% to 0.9%]) and an increase of predicted FEF25-75%/FVC (14.9%; CI 95%: [2.9% to 26.8%]) without changes of FEV1/FVC. Conclusions Exposure to vehicular traffic air pollution is associated with a small but significant reduction of FVC without a reduction of FEV1/FVC.
- Lacrimal Cytokines Assessment in Subjects Exposed to Different Levels of Ambient Air Pollution in a Large Metropolitan Area(2015) MATSUDA, Monique; BONATTI, Rodolfo; MARQUEZINI, Monica V.; GARCIA, Maria L. B.; SANTOS, Ubiratan P.; BRAGA, Alfesio L. F.; ALVES, Milton R.; SALDIVA, Paulo H. N.; MONTEIRO, Mario L. R.Background Air pollution is one of the most environmental health concerns in the world and has serious impact on human health, particularly in the mucous membranes of the respiratory tract and eyes. However, ocular hazardous effects to air pollutants are scarcely found in the literature. Design Panel study to evaluate the effect of different levels of ambient air pollution on lacrimal film cytokine levels of outdoor workers from a large metropolitan area. Methods Thirty healthy male workers, among them nineteen professionals who work on streets (taxi drivers and traffic controllers, high pollutants exposure, Group 1) and eleven workers of a Forest Institute (Group 2, lower pollutants exposure compared to group 1) were evaluated twice, 15 days apart. Exposure to ambient PM2.5 (particulate matter equal or smaller than 2.5 mu m) was 24 hour individually collected and the collection of tears was performed to measure interleukins (IL) 2, 4, 5 and 10 and interferon gamma (IFN-gamma) levels. Data from both groups were compared using Student's t test or Mann-Whitney test for cytokines. Individual PM2.5 levels were categorized in tertiles (lower, middle and upper) and compared using one-way ANOVA. Relationship between PM2.5 and cytokine levels was evaluated using generalized estimating equations (GEE). Results PM2.5 levels in the three categories differed significantly (lower: <= 22 mu g/m(3); middle: 23-37.5 mu g/m(3); upper: >37.5 mu g/m(3); p<0.001). The subjects from the two groups were distributed unevenly in the lower category (Group 1 = 8%; Group 2 = 92%), the middle category (Group 1 = 89%; Group 2 = 11%) and the upper category (Group 1 = 100%). A significant relationship was found between IL-5 and IL-10 and PM2.5 levels of the group 1, with an average decrease of 1.65 pg/mL of IL-5 level and of 0.78 pg/mL of IL-10 level in tear samples for each increment of 50 mu g/m(3) of PM2.5 (p = 0.01 and p = 0.003, respectively). Conclusion High levels of PM2.5 exposure is associated with decrease of IL-5 and IL-10 levels suggesting a possible modulatory action of ambient air pollution on ocular surface immune response.
conferenceObject Exhaled nitric oxide in traffic professionals exposed to ambient urban air pollution(2012) OSHIRO, Claudia; KOGISO, Diogo; ROMANHOLO, Beatriz; MARTINS, Lourdes; BRAGA, Alfesio; SALDIVA, Paulo; GARCIA, Maria- Exposure to fine particles increases blood pressure of hypertensive outdoor workers: A panel study(2019) SANTOS, Ubiratan Paula; BRAGA, Alfesio Luis Ferreira; GARCIA, Maria Lucia Bueno; PEREIRA, Luiz Alberto Amador; LIN, Chin An; CHIARELLI, Paulo S.; ANDRE, Carmen Diva Saldiva de; ANDRE, Paulo Afonso de; SINGER, Julio M.; SALDIVA, Paulo Hilario NascimentoBackground: Hypertension and air pollution are two important risk factors for cardiovascular morbidity and mortality. Although several studies suggest that air pollution has a significant impact on blood pressure, studies on long-term effects are sparse and still controversial. Objective: To evaluate the effects of exposure of outdoor workers to different levels of traffic-generated PM2.5 on blood pressure. Design: This is an observational panel study. Participants: 88 non-smoking workers exposed to different concentrations of air pollution were evaluated weekly along four successive weeks. Measurements: In each week, personal monitoring of 24-h PM2.5 concentration and 24-h ambulatory blood pressure were measured. The association between blood pressure variables and PM2.5, adjusted for age, body mass index, time in job, daily work hours, diabetes, hypertension and cholesterol was assessed by means of multiple linear regression models fitted by least squares. Results: Exposure to PM2.5 (ranging from 8.5 to 89.7 mu g/m(3)) is significantly and consistently associated with an increase in average blood pressure. An elevation of 10 mu g/m(3) in the concentration of PM2.5 is associated with increments of 3.9 mm Hg (CI 95% = [1.5; 6.3]) in average systolic 24-h blood pressure for hypertensive and/or diabetic workers. Conclusion: Exposure to fine particles, predominantly from vehicular traffic, is associated with elevated blood pressure in hypertensive and/or diabetic workers.
article 1 Citação(ões) na Scopus Maternal mortality profile in Great ABC Region from 1997 to 2005(2011) TOGNINI, Silvana; GARCIA, Maria Lucia Bueno; BRAGA, Alfesio Luis Ferreira; MARTINS, Lourdes ConceicaoMaternal mortality profile in Great ABC Region from 1997 to 2005 Objective: To analyze the maternal mortality in the ABC Region, comparing indicators from the Committee for the Study of Maternal Mortality in the Great ABC Region (CEMM) of the II Regional Health Center of Santo Andre (DIR II), and the State Data Analysis System Foundation (SEADE). Methods: This is a cross sectional study. The information was obtained from the database of CEMM DIR II Santo Andre, which includes data from seven counties of the ABC Region. We analyzed all deaths of childbearing-age women that occurred from 1997 to 2005 in that region. The paired t test, Wilcoxon and Kruskal-Wallis tests were used for statistical analysis. Results: There were differences regarding the maternal mortality rates in the towns of Diadema, Sao Bernardo do Campo, Santo Andre and DIR 11, with the coefficients calculated by CEMM being higher than those provided by the SEADE (p < 0.001). Concerning the towns of Maua, Rio Grande da Serra, Ribeirao Pires and Sao Caetano do Sul, no significant differences were observed between these two coefficients (p > 0.05), although the coefficients provided by CEMM were higher than the coefficients obtained from SEADE. Conclusion: Our results demonstrate that the official data of maternal mortality in Brazil are still underestimated and point to the lack of healthcare quality during pregnancy, childbirth and postpartum.conferenceObject Lacrimal cytokines assessment in subjects exposed to different levels of ambient air pollution in a large metropolitan area(2014) MATSUDA, Monique; BONATTI, Rodolfo; MARQUEZINI, Monica; GARCIA, Maria L.; SANTOS, Ubiratan P.; BRAGA, Alfesio L.; KREMPEL, Paloma Gava; SALDIVA, Paulo H.; RUIZ-ALVES, Milton; MONTEIRO, Mario L. R.