ADALBERTO STUDART NETO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- From clinical phenotype to proteinopathy: molecular neuroimaging in neurodegenerative dementias(2022) STUDART-NETO, Adalberto; COUTINHO, Artur MartinsNeurodegenerative dementias are characterized by the abnormal accumulation of misfolded proteins. However, its diagnostic criteria are still based on the clinical phenotype. The development of biomarkers allowed in vivo detection of pathophysiological processes. This article aims to make a non-systematic review of the use of molecular neuroimaging as a biomarker. Molecular neuroimaging is based on the use of radiotracers for image acquisition. The radiotracer most used in PET is F-18-fluorodeoxyglucose (FDG), with which it is possible to study the regional brain glucose metabolism. The pattern of regional hypometabolism provides neuroanatomical information on the neurodegenerative process,which, in turn, has a good specificity for each type of proteinopathy. FDG is very useful in the differential diagnosis of neurodegenerative dementias through the regional pattern of involvement, including dementia with Lewy bodies and the spectrum of frontotemporal dementia. More recently, radiotracers with specific ligands to some of the pathological proteins have been developed. Pittsburgh compound B (PIB) labeled with C-11 and the ligands that use F-18 (florbetapir, florbetaben and flutemetamol) are the most used radiotracers for the detection of insoluble beta-amyloid peptide in Alzheimer's disease (AD). A first generation of ligands for tau protein has been developed, but it has some affinity for other non-tau protein aggregates. A second generation has the advantage of having a higher affinity for hyperphosphorylated tau protein, including in primary tauopathies.
conferenceObject Brain Health Signature in Superagers: A Multimodal Brain MRI Study(2022) GODOY, Laiz de; STUDART-NETO, Adalberto; NITRINI, Ricardo; JAGER, Rolf; BISDAS, Sotirios; LEITE, Claudia da CostabookPart Coma e rebaixamento do nível de consciência(2022) CALDERARO, Marcelo; STUDART NETO, Adalberto; RABELLO, Getúlio Daré (in memoriam); BRANDãO NETO, Rodrigo Antonio- Normal pressure hydrocephalus: an update(2022) PASSOS-NETO, Carlos Eduardo Borges; LOPES, Cesar Castello Branco; TEIXEIRA, Mauricio Silva; NETO, Adalberto Studart; SPERA, Raphael RibeiroNormal pressure hydrocephalus (NPH) has been a topic of debate since its introduction in publications. More frequent in the elderly population, it is characterized by gait disturbance, urinary urge incontinence and cognitive decline. Therefore, it is a clinical-radiological entity with relatively common findings for the age group, which together may have greater specificity. Therefore, its diagnosis must be careful for an adequate selection of patients for treatment with ventricular shunt, since the symptoms are potentially reversible. The tap test has a high positive predictive value as a predictor of therapeutic response, but a negative test does not exclude the possibility of treatment. Scientific efforts in recent years have been directed towards a better understanding of NPH and this narrative review aims to compile recent data from the literature in a didactic way for clinical practice.
- Translation, cross-cultural adaptation, and validity of the Brazilian version of the Cognitive Function Instrument(2022) STUDART-NETO, Adalberto; MORAES, Natália Cristina; SPERA, Raphael Ribeiro; MERLIN, Silvia Stahl; PARMERA, Jacy Bezerra; JALUUL, Omar; SANCHESYASSUDA, Mônica; BRUCKI, Sonia Maria Dozzi; NITRINI, RicardoABSTRACT. Subjective cognitive decline (SCD) is defined as a self-perception of a progressive cognitive impairment, which is not detected objectively through neuropsychological tests. The Alzheimer's Disease Cooperative Study developed the Cognitive Function Instrument (CFI) to evaluate individuals with SCD. The CFI consists of two versions, namely, a self-report and a partner report. Objective: This study aimed to translate CFI into Brazilian Portuguese, perform a cross-cultural adaptation, and validate the Brazilian version. Methods: The translation and transcultural adaptation process consisted of six stages, and the preliminary version was answered by a sample of individuals recruited among the patients’ caregivers from a cognitive neurology outpatient clinic. Finally, the final Brazilian version of the CFI was applied to a sample of nondemented older adults to validate the instrument, which was divided into with and without SCD, according to the answer “yes” for the question: “Do you feel like your memory is becoming worse?”. Results: The final version of CFI showed a high level of acceptability as an assessment tool in nondemented older adults. Participants with SCD had higher scores in the CFI self-report compared with those without complaints. In the receiver operating characteristic curve analysis, the area under the curve of the CFI self-report was 0.865 (95% confidence interval 0.779–0.951), and the cutoff score of 2.0 was the one that best distinguished the SCD group from the control group, with a sensitivity of 73.3% and a specificity of 81.5%. Conclusions: CFI proved to be an instrument with good accuracy and easy applicability to identify older adults with SCD.
- Declínio cognitivo subjetivo, comprometimento cognitivo leve e demência - diagnóstico sindrômico: recomendações do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia(2022) SMID, Jerusa; STUDART-NETO, Adalberto; CÉSAR-FREITAS, Karolina Gouveia; DOURADO, Marcia Cristina Nascimento; KOCHHANN, Renata; BARBOSA, Breno José Alencar Pires; SCHILLING, Lucas Porcello; BALTHAZAR, Márcio Luiz Figueiredo; FROTA, Norberto Anízio Ferreira; SOUZA, Leonardo Cruz de; CARAMELLI, Paulo; BERTOLUCCI, Paulo Henrique Ferreira; CHAVES, Márcia Lorena Fagundes; BRUCKI, Sonia Maria Dozzi; NITRINI, Ricardo; RESENDE, Elisa de Paula França; VALE, Francisco Assis CarvalhoABSTRACT This consensus, performed by the Brazilian Academy of Neurology (BAN) will approach practically how to evaluate patients with cognitive complaints and how to clinically and etiologically diagnose the three clinical syndromes associated with the different stages of cognitive decline: subjective cognitive decline (SCD), mild cognitive impairment (MCI), and dementia. This BAN consensus discusses SCD diagnosis for the first time, updates MCI and dementia diagnoses, recommends the adequate cognitive tests and the relevant etiological work-up and care of patients with cognitive decline at different levels of care within the Brazilian Unified Health System. We also review the main assessment instruments used in Brazil and Latin America.