SANDRA GOFINET PASOTO

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Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/03 - Laboratório de Medicina Laboratorial, Hospital das Clínicas, Faculdade de Medicina

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  • article 134 Citação(ões) na Scopus
    How immunological profile drives clinical phenotype of primary Sjogren's syndrome at diagnosis: analysis of 10,500 patients (Sjogren Big Data Project)
    (2018) BRITO-ZERON, P.; ACAR-DENIZLI, N.; NG, W. F.; ZEHER, M.; RASMUSSEN, A.; MANDL, T.; SEROR, R.; LI, X.; BALDINI, C.; GOTTENBERG, J. -E.; DANDA, D.; QUARTUCCIO, L.; PRIORI, R.; HERNANDEZ-MOLINA, G.; ARMAGAN, B.; KRUIZE, A. A.; KWOK, S. -K.; KVARNSTROM, M.; PRAPROTNIK, S.; SENE, D.; BARTOLONI, E.; SOLANS, R.; RISCHMUELLER, M.; SUZUKI, Y.; ISENBERG, D. A.; VALIM, V.; WILAND, P.; NORDMARK, G.; FRAILE, G.; BOOTSMA, H.; NAKAMURA, T.; GIACOMELLI, R.; DEVAUCHELLE-PENSEC, V.; KNOPF, A.; BOMBARDIERI, M.; TREVISANI, V. -F; HAMMENFORS, D.; PASOTO, S. G.; RETAMOZO, S.; GHEITA, T. A.; ATZENI, F.; MOREL, J.; VOLLENVEIDER, C.; HORVATH, I-F.; SIVILS, K. L.; OLSSON, P.; VITA, S. De; SANCHEZ-GUERRERO, J.; KILIC, L.; WAHREN-HERLENIUS, M.; MARIETTE, X.; RAMOS-CASALS, M.
    Objective. To evaluate the influence of the main immunological markers on the disease phenotype at diagnosis in a large international cohort of patients with primary Sjogren's syndrome (SjS). Methods. The Big Data Sjogren Project Consortium is an international, multicentre registry created in 2014. As a first step, baseline clinical information from leading centres on clinical research in SjS of the 5 continents was collected. The centres shared a harmonised data architecture and conducted cooperative online efforts in order to refine collected data under the coordination of a big data statistical team. Inclusion criteria were the fulfillment of the 2002 classification criteria. Immunological tests were carried out using standard commercial assays. Results. By January 2018, the participant centres had included 10,500 valid patients from 22 countries. The cohort included 9,806 (93%) women and 694 (7%) men, with a mean age at diagnosis of primary SjS of 53 years, mainly White (78%) and included from European countries (71%). The frequency of positive immunological markers at diagnosis was 79.3% for ANA, 73.2% for anti-Ro, 48.6% for RF, 45.1% for anti-La, 13.4% for low C3 levels, 14.5% for low C4 levels and 7.3% for cryoglobulins. Positive autoantibodies (ANA, Ro, La) correlated with a positive result in salivary gland biopsy, while hypocomplementaemia and especially cryoglobulinaemia correlated with systemic activity (mean ESSDAI score of 17.7 for ctyoglobulins, 11.3 for low C3 and 9.2 for low C4, in comparison with 3.8 for negative markers). The immunological markers with a great number of statistically-significant associations (p<0.001) in the organ-by-organ ESSDAI evaluation were cryoglobulins (9 domains), low C3 (8 domains), anti-La (7 domains) and low C4 (6 domains). Conclusion. We confirm the strong influence of immunological markers on the phenotype of primary SjS at diagnosis in the largest multi-ethnic international cohort ever analysed, with a greater influence for cryoglobulinaemic-related markers in comparison with Ro/La autoantibodies and ANA. Immunological patterns play a central role in the phenotypic expression of the disease already at the time of diagnosis, and may guide physicians to design a specific personalised management during the follow-up of patients with primary SjS.
  • conferenceObject
    PERIPHERAL NERVOUS SYSTEM DISEASE IN SYSTEMIC LUPUS ERYTHEMATOSUS: THE ROLE OF PREDISPOSING CONDITIONS
    (2018) FARGETTI, S.; BONFA, E.; SHINJO, S. K.; PASOTO, S. G.; SEGURO, L. P. C.; LOPES, M. R. U.; GONCALVES, C. R.; BORBA, E. F.
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    Salivary gland damage in Sjogren's syndrome: are endothelial and vascular alterations associated with the secretion of IL-17?
    (2018) LOURENCO, Silvia V.; BOLOGNA, Sheyla B.; CAVALCANTE, Wanessa S.; PASOTO, Sandra G.; FLOREZI, Giovanna P.
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    HOW ETHNICITY MODIFIES SYSTEMIC ACTIVITY OF PRIMARY SJOGREN SYNDROME: ANALYSIS OF BASELINE ESSDAI SCORES IN A MULTI-ETHNIC INTERNATIONAL COHORT
    (2018) RETAMOZO, Soledad; HERNANDEZ-MOLINA, Gabriela; VALIM, Valeria; TREVISANI, Virginia Fernandes Moca; PASOTO, Sandra G.; ACAR-DENIZLI, Nihan; ZEHER, Margit; SIVILS, Kathy; MANDL, Thomas; SEROR, Raphaele; LI, Xiaomei; BALDINI, Chiara; MARIETTE, Xavier; GOTTENBERG, Jacques-Ericn; DANDA, Debashish; PRIORI, Roberta; QUARTUCCIO, Luca; ARMAGAN, Berkan; KRUIZE, Aike A.; KWOK, Seung-Ki; WAHREN-HERLENIUS, Marie; PRAPROTNIK, Sonja; SENE, Damien; BARTOLONI, Elena; RISCHMUELLER, Maureen; SOLANS, Roser; SUZUKI, Yasunori; ISENBERG, David; WILAND, Piotr; NORDMARK, Gunnel; FRAILE, Guadalupe; BOOTSMA, Hendrika; NAKAMURA, Takashi; GIACOMELLI, Roberto; DEVAUCHELLE-PENSEC, Valerie; HOFAUER, Benedikt; BOMBARDIERI, Michele; HAMMENFORS, Daniel; CARSONS, Steven E.; GHEITA, Tamer A.; ATZENI, Fabiola; MOREL, Jacques; VOLLENVEIDER, Cristina; RAMOS-CASALS, Manuel; BRITO-ZERON, Pilar
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    SHORT AND LONG-TERM FOLLOW-UP OF PERIPHERAL NEUROPATHY DUE TO SYSTEMIC LUPUS ERYTHEMATOSUS: EVIDENCE OF A FAVORABLE OUTCOME
    (2018) FARGETTI, S.; BONFA, E.; SHINJO, S. K.; PASOTO, S. G.; SEGURO, L. P. C.; LOPES, M. R. U.; GONCALVES, C. R.; BORBA, E. F.
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    Ultrasonography of major salivary glands in juvenile Sjogren's syndrome: an international multicentre study
    (2018) HAMMENFORS, Daniel S.; VALIM, Valeria; BICA, Blanca E. R. G.; PASOTO, Sandra G.; LILLEBY, Vibke; NIETO-GONZALEZ, Juan Carlos; SILVA, Clovis A.; MOSSEL, Esther; PEREIRA, Rosa M. R.; COELHO, Aline; BOOTSMA, Hendrika; THATAYATIKOM, Akaluck; BRUN, Johan G.; JONSSON, Roland; JONSSON, Malin V.
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    How Immunological Profile Drives Clinical Phenotype of Primary Sjogren's Syndrome at Diagnosis: Analysis of 10.500 Patients (Sjogren Big Data Project)
    (2018) RETAMOZO, Soledad; ACAR-DENIZLI, Nihan; NG, Wan-Fai; ZEHER, Margit; RASMUSSEN, Astrid; MANDL, Thomas; SEROR, Raphaele; LI, Xiaomei; BALDINI, Chiara; GOTTENBERG, Jacques-Eric; DANDA, Debashish; QUARTUCCIO, Luca; PRIORI, Roberta; HERNANDEZ-MOLINA, Gabriela; ARMAGAN, Berkan; KRUIZE, Aike A.; KWOK, Seung-Ki; KVARNSTROM, Marika; PRAPROTNIK, Sonja; SENE, Damien; BARTOLONI, Elena; SOLANS, Roser; RISCHMUELLER, Maureen; SUZUKI, Yasunori; ISENBERG, David A.; VALIM, Valeria; WILAND, Piotr; NORDMARK, Gunnel; FRAILE, Guadalupe; BOOTSMA, Hendrika; NAKAMURA, Takashi; GIACOMELLI, Roberto; DEVAUCHELLE-PENSEC, Valerie; KNOPF, Andreas; BOMBARDIERI, Michele; TREVISANI, Virginia Fernandes; HAMMENFORS, Daniel S.; PASOTO, Sandra G.; GHEITA, Tamer A.; ATZENI, Fabiola; MOREL, Jacques; VOLLENVEIDER, Cristina; HORVATH, Ildiko-Fanny; SIVILS, Kathy L.; OLSSON, Peter; VITA, Salvatore De; SANCHEZ-GUERRERO, Jorge; KILIC, Levent; WAHREN-HERLENIUS, Marie; MARIETTE, Xavier; RAMOS-CASALS, Manuel; BRITO-ZERON, Pilar
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    Is Sjogren's syndrome sialadenitis similar to salivary gland impairment in Lupus erythematosus?
    (2018) BOLOGNA, Sheyla B.; FLOREZI, Giovanna; CAVALCANTE, Wanessa S.; PASOTO, Sandra G.; LOURENCO, Silvia V.
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    How ethnicity modifies systemic activity of primary Sjogren syndrome: analysis of baseline ESSDAI scores in a multi-ethnic international cohort
    (2018) RETAMOZO, Soledad; KOSTOV, Belchin; ZEHER, Margit; SIVILS, Kathy; MANDL, Thomas; SEROR, Raphaele; LI, Xiaomei; BALDINI, Chiara; MARIETTE, Xavier; GOTTENBERG, Jacques-Eric; DANDA, Debashish; PRIORI, Roberta; QUARTUCCIO, Luca; HERNANDEZ-MOLINA, Gabriela; ARMAGAN, Berkan; KRUIZE, Aike A.; KWOK, Seung-Ki; WAHREN-HERLENIUS, Marie; PRAPROTNIK, Sonja; SENE, Damien; BARTOLONI, Elena; RISCHMUELLER, Maureen; SOLANS, Roser; SUZUKI, Yasunori; ISENBERG, David; VALIM, Valeria; WILAND, Piotr; NORDMARK, Gunnel; FRAILE, Guadalupe; BOOTSMA, Hendrika; NAKAMURA, Takashi; GIACOMELLI, Roberto; DEVAUCHELLE-PENSEC, Valerie; HOFAUER, Benedikt; BOMBARDIERI, Michele; TREVISANI, Virginia Fernandes Moca; HAMMENFORS, Daniel; PASOTO, Sandra G.; CARSONS, Steven E.; GHEITA, Tamer A.; ATZENI, Fabiola; MOREL, Jacques; VOLLENVEIDER, Cristina; BRITO-ZERON, Pilar; RAMOS-CASALS, Manuel
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    INFLUENCE OF EPIDEMIOLOGY AND ETHNICITY ON SYSTEMIC EXPRESSION OF PRIMARY SJOGREN SYNDROME IN 9974 PATIENTS
    (2018) RETAMOZO, S.; ACAR-DENIZLI, N.; NG, W. Fai; ZEHER, M.; RASMUSSEN, A.; SEROR, R.; LI, X.; BALDINI, C.; GOTTENBERG, J. -E.; DANDA, D.; QUARTUCCIO, L.; PRIORI, R.; HERNANDEZ-MOLINA, G.; ARMAGAN, B.; KRUIZE, A. A.; KWOK, S. -K.; WAHREN-HERLENIUS, M.; PRAPROTNIK, S.; SENE, D.; BARTOLONI, E.; SOLANS, R.; RISCHMUELLER, M.; MANDL, T.; SUZUKI, Y.; ISENBERG, D.; VALIM, V.; WILAND, P.; NORDMARK, G.; FRAILE, G.; BOOTSMA, H.; NAKAMURA, T.; GIACOMELLI, R.; DEVAUCHELLE-PENSEE, V.; HOFAUER, B.; BOMBARDIERI, M.; TREVISANI, V. Fernandes Moca; HAMMENFORS, D.; PASOTO, S. G.; GHEITA, T. A.; ATZENI, F.; MOREL, J.; VOLLENVEIDER, C.; BRITO-ZERON, P.; RAMOS-CASALS, M.