SANDRA GOFINET PASOTO

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Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/03 - Laboratório de Medicina Laboratorial, Hospital das Clínicas, Faculdade de Medicina

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  • article 51 Citação(ões) na Scopus
    Systemic manifestations of primary Sjogren's syndrome out of the ESSDAI classification: prevalence and clinical relevance in a large international, multi-ethnic cohort of patients
    (2019) RETAMOZO, S.; ACAR-DENIZLI, N.; RASMUSSEN, A.; HORVATH, I. F.; BALDINI, C.; PRIORI, R.; SANDHYA, P.; HERNANDEZ-MOLINA, G.; ARMAGAN, B.; PRAPROTNIK, S.; KVARNSTROM, M.; GERLI, R.; SEBASTIAN, A.; SOLANS, R.; RISCHMUELLER, M.; PASOTO, S. G.; VALIM, V.; NORDMARK, G.; KRUIZE, A. A.; NAKAMURA, H.; HOFAUER, B.; GIACOMELLI, R.; TREVISANI, V. Fernandes Moca; DEVAUCHELLE-PENSEC, V.; ATZENI, F.; GHEITA, T. A.; CONSANI-FERNANDEZ, S.; SZANTO, A.; SIVILS, K.; GATTAMELATA, A.; DANDA, D.; KILIC, L.; BARTOLONI, E.; BOMBARDIERI, S.; SANCHEZ-GUERRERO, J.; WAHREN-HERLENIUS, M.; MARIETTE, X.; RAMOS-CASALS, M.; BRITO-ZERON, P.
    Objectives: To analyse the frequency and characterise the systemic presentation of primary Sjogren's syndrome (SS) out of the ESSDAI classification in a large international, multi-ethnic cohort of patients. Methods: The Big Data Sjogren Project Consortium is an international, multicentre registry based on world-wide data-sharing and cooperative merging of pre-existing clinical SS databases from leading centres in clinical research in SS from the five continents. A list of 26 organ-by-organ systemic features not currently included in the ESSDAI classification was defined according to previous studies; these features were retrospectively recorded. Results: Information about non-ESSDAI features was available in 6331 patients [5,917 female, mean age at diagnosis 52 years, mainly White (86.3%)]. A total of 1641 (26%) patients had at least one of the ESSDAI systemic features. Cardiovascular manifestations were the most frequent organ-specific group of non-ESSDAI features reported in our patients (17% of the total cohort), with Raynaud's phenomenon being reported in 15%. Patients with systemic disease due to non-ESSDAI features had a lower frequency of dry mouth (90.7% vs. 94.1%, p<0.001) and positive minor salivary gland biopsy (86.7% vs. 89%, p=0.033), a higher frequency of anti-Ro/SSA (74.7% vs. 68.7%, p<0.001), anti-La/SSB antibodies (44.5% vs. 40.4%, p=0.004), ANA (82.7% vs. 79.5%, p=0.006), low C3 levels (17.4% vs. 9.7%, p<0.001), low C4 levels (14.4% vs. 9.6%, p<0.001), and positive serum cryoglobulins (8.6% vs. 5.5%, p=0.001). Systemic activity measured by the ESSDAI, clinESSDAI and DAS was higher in patients with systemic disease out of the ESSDAI in comparison with those without these features (p<0.001 for all comparisons). Conclusions: More than a quarter of patients with primary SS may have systemic manifestations not currently included in the ESSDAI classification, with a wide variety of cardiovascular, digestive, pulmonary, neurological, ocular, ENT (ear, nose, and throat), cutaneous and urological features that increase the scope of the systemic phenotype of the disease. However, the individual frequency of each of these non-ESSDAI features was very low, except for Raynaud's phenomenon.
  • conferenceObject
    HOW THE AGE AT DIAGNOSIS MODIFIES THE PHENOTYPE OF PRIMARY SJOGREN SYNDROME: ANALYSIS IN 11,420 PATIENTS (BIG DATA SJOGREN PROJECT)
    (2019) RETAMOZO, Soledad; ACAR-DENIZLI, Nihan; NG, Wan Fai; HORVATH, Ildiko Fanny; RASMUSSEN, Astrid; SEROR, Raphaele; Li Xiaomei; BALDINI, Chiara; GOTTENBERG, Jacques-Eric; SANDHYA, Pulukool; QUARTUCCIO, Luca; PRIORI, Roberta; HERNANDEZ-MOLINA, Gabriela; ARMAGAN, Berkan; KRUIZE, Aike A.; KWOK, Seung-Ki; KVARNSTROM, Marika; PRAPROTNIK, Sonja; SENE, Damien; BOCCI, Elena Bartoloni; SOLANS-LAQUE, Roser; RISCHMUELLER, Maureen; MANDL, Thomas; SUZUKI, Yasunori; ISENBERG, David; VALIM, Valeria; SEBASTIAN, Agata; NORDMARK, Gunnel; BOOTSMA, Hendrika; NAKAMURA, Hideki; GIACOMELLI, Roberto; DEVAUCHELLE-PENSEC, Valerie; HOFAUER, Benedikt; BOMBARDIERI, Michele; TREVISANI, Virginia Fernandes Moca; HAMMENFORS, Daniel; PASOTO, Sandra; GHEITA, Tamer A.; ATZENI, Fabiola; MOREL, Jacques; VOLLENVEIDER, Cristina; CONSANI-FERNANDEZ, Sandra; MARIETTE, Xavier; RAMOS-CASALS, Manuel; BRITO-ZERON, Pilar
  • article 10 Citação(ões) na Scopus
    Recommendations from the Brazilian society of rheumatology for the diagnosis of Sjogren's syndrome (Part I): glandular manifestations (systematic review)
    (2019) TREVISANI, Virginia Fernandes Moca; PASOTO, Sandra Gofinet; FERNANDES, Marilena Leal Mesquita Silvestre; LOPSE, Maria Lucia Lemos; FIALHO, Sonia Cristina de Magalhaes Souza; PINHEIRO, Aysa Cesar; SANTOS, Laura Caldas dos; APPENZELLER, Simone; FIDELIX, Tania; RIBEIRO, Sandra Lucia Euzebio; BRITO, Danielle Christinne Soares Egypto de; LIBORIO, Tatiana; SANTOS, Maria Carmen Lopes Ferreira Silva; TANURE, Leandro; GENNARI, Juliana D. Agostino; CIVILE, Vinicius Tassoni; PINTO, Ana Carolina Pereira Nunes; OLIVEIRA, Fabiola Reis; SOUSA, Jaqueline Martins de; MIYAMOTO, Samira Tatiyama; VALIM, Valeria
    Background Primary Sjogren's syndrome (pSS) is a systemic immune-mediated disease whose main characteristic is exocrine gland inflammation and, subsequent reduction in tear and saliva production. A delayed diagnosis is common due to the nonspecific clinical manifestations of disease. The aim of the present study was to develop recommendations for the diagnosis of glandular manifestations of pSS based on evidence and expert opinion. Main body of the abstract We conducted a systematic literature review to retrieve the best evidence available on the accuracy of diagnostic tests for pSS. We also held two in-person meetings with experts (rheumatologists, pathologists, ophthalmologists and dentists) to establish their level of agreement using the Delphi method. Ultimately, we generated 18 recommendations that aim to facilitate the diagnosis of the glandular manifestations of pSS. Conclusion The diagnosis of glandular manifestations of pSS is complex and multidisciplinary. It requires specific knowledge in the field of ophthalmology, immunology, pathology and imaging, making it compulsory for the rheumatologist to work with professionals from these different areas in order to improve accuracy and early diagnosis. Glandular dysfunction tests, ANA, RF, Anti-Ro, protein electrophoresis, urinalysis, blood count, C-Reactive protein, complement, testing for syphilis and viruses (HCV, HIV) and SGUS should be investigated when dryness or systemic manifestation are present. Minor salivary gland biopsy is recommended for all anti-Ro negative or incomplete criteria cases.
  • conferenceObject
    LYMPHOMA ARISING AT THE TIME OF DIAGNOSIS OF PRIMARY SJOGREN SYNDROME: A HIGHLY-ACTIVE SYSTEMIC SUBSET OF THE DISEASE
    (2019) RETAMOZO, Soledad; ACAR-DENIZLI, Nihan; Wan Fai Ng; SZANTO, Antonia; RASMUSSEN, Astrid; SEROR, Raphaele; Li Xiaomei; BALDINI, Chiara; GOTTENBERG, Jacques-Eric; SANDHYA, Pulukool; QUARTUCCIO, Luca; PRIORI, Roberta; HERNANDEZ-MOLINA, Gabriela; ARMAGAN, Berkan; KRUIZE, Aike A.; KWOK, Seung-Ki; KVARNSTROM, Marika; PRAPROTNIK, Sonja; SENE, Damien; SOLANS-LAQUE, Roser; RISCHMUELLER, Maureen; MANDL, Thomas; SUZUKI, Yasunori; ISENBERG, David; VALIM, Valeria; SEBASTIAN, Agata; NORDMARK, Gunnel; BOOTSMA, Hendrika; NAKAMURA, Hideki; GIACOMELLI, Roberto; DEVAUCHELLE-PENSEC, Valerie; HOFAUER, Benedikt; BOMBARDIERI, Michele; TREVISANI, Virginia Fernandes Moca; HAMMENFORS, Daniel; PASOTO, Sandra; AGHEITA, Tamer; ATZENI, Fabiola; MOREL, Jacques; VOLLENVEIDER, Cristina; CONSANI-FERNANDEZ, Sandra; MARIETTE, Xavier; RAMOS-CASALS, Manuel; BRITO-ZERON, Pilar; BOCCI, Elena Bartoloni
  • conferenceObject
    Systemic Manifestations of Primary Sjogren Syndrome out of the ESSDAI Classification: Prevalence and Clinical Relevance in a Large International, Multi-ethnic Cohort of Patients
    (2019) RETAMOZO, Soledad; ACAR-DENIZLI, Nihan; RASMUSSEN, Astrid; HORVATH, Ildiko Fanny; BALDINI, Chiara; PRIORI, Roberta; SANDHYA, Pulukool; HERNANDEZ-MOLINA, Gabriela; ARMAGAN, Berkan; PRAPROTNIK, Sonja; KVARNSTROM, Marika; GERLI, Roberto; SEBASTIAN, Agata; SOLANS-LAQUE, Roser; RISCHMUELLER, Maureen; PASOTO, Sandra G.; VALIM, Valeria; NORDMARK, Gunnel; KRUIZE, Aike; NAKAMURA, Takashi; HOFAUER, Benedikt; GIACOMELLI, Roberto; TREVISANI, Virginia Fernandes Moca; PENSEC, Valerie Devauchelle; ATZENI, Fabiola; GHEITA, Tamer A.; CONSANI-FERNANDEZ, Sandra; SZANTO, Antonia; SIVILS, Kathy; GATTAMELATA, Angelina; DANDA, Debashish; KILIC, Levent; BARTOLONI, Elena; BOMBARDIERI, Stefano; SANCHEZ-GUERRERO, Jorge; WAHREN-HERLENIUS, Marie; MARIETTE, Xavier; RAMOS-CASALS, Manuel; BRITO-ZERON, Pilar
  • conferenceObject
    Proposition of a Novel Animal Model of Systemic Sclerosis Induced by Type V Collagen in C57BL/6 Mice Reproducing Fibrosis, Vasculopathy and Autoimmunity
    (2019) TEODORO, Walcy; VELOSA, Ana Paula; QUEIROZ, Zelita Aparecida; ARAUJO, Lais; CATANOZI, Sergio; FILHO, Antonio dos Santos; BUENO, Cleonice; VENDRAMINI, Margarete; FERNEZLIAN, Sandra Moraes; EHER, Esmeralda; MIRANDA, Jurandir Tomaz de; LOPES, Fernanda; PASOTO, Sandra G.; SAMPAIO-BARROS, Percival Degrava; CAPELOZZI, Vera Luiza
  • conferenceObject
    PHENOTYPE OF BIOPSY-PROVEN PATIENTS WITH PRIMARY SJOGREN SYNDROME LACKING RO AUTOANTIBODIES: HIGH FREQUENCY OF DRYNESS SYMPTOMS WITH LOW SYSTEMIC ACTIVITY (BIG DATA SJOGREN PROJECT)
    (2019) RETAMOZO, Soledad; ACAR-DENIZLI, Nihan; NG, Wan Fai; HORVATH, Ildiko Fanny; RASMUSSEN, Astrid; SEROR, Raphaele; Li Xiaomei; BALDINI, Chiara; GOTTENBERG, Jacques-Eric; SANDHYA, Pulukool; QUARTUCCIO, Luca; PRIORI, Roberta; HERNANDEZ-MOLINA, Gabriela; ARMAGAN, Berkan; KRUIZE, Aike A.; KWOK, Seung-Ki; KVARNSTROM, Marika; PRAPROTNIK, Sonja; SENE, Damien; GERLI, Roberto; SOLANS-LAQUE, Roser; RISCHMUELLER, Maureen; MANDL, Thomas; SUZUKI, Yasunori; ISENBERG, David; VALIM, Valeria; SEBASTIAN, Agata; NORDMARK, Gunnel; BOOTSMA, Hendrika; NAKAMURA, Hideki; GIACOMELLI, Roberto; DEVAUCHELLE-PENSEC, Valerie; HOFAUER, Benedikt; BOMBARDIERI, Michele; TREVISANI, Virginia Fernandes Moca; HAMMENFORS, Daniel; PASOTO, Sandra; GHEITA, Tamer A.; ATZENI, Fabiola; MOREL, Jacques; VOLLENVEIDER, Cristina; CONSANI-FERNANDEZ, Sandra; MARIETTE, Xavier; RAMOS-CASALS, Manuel; BRITO-ZERON, Pilar
  • article 11 Citação(ões) na Scopus
    V Brazilian consensus guidelines for detection of anti-cell autoantibodies on hep-2 cells
    (2019) CRUVINEL, Wilson de Melo; ANDRADE, Luis Eduardo Coelho; MUHLEN, Carlos Alberto von; DELLAVANCE, Alessandra; XIMENES, Antonio Carlos; BICHARA, Carlos David; BUENO, Cleonice; MANGUEIRA, Cristovao Luis Pitangueira; BONFA, Eloisa; BRITO, Fabiano de Almeida; FLUMIAN, Fernanda Bull; SILVA, Glaucielen Gomes da; REGO, Jozelia; ANJOS, Lisiane Maria Ericoni dos; SLHESSARENKO, Natasha; PASOTO, Sandra Gofinet; NEVES, Suzane Pretti Figueiredo; VALIM, Valeria; SANTOS, Wilton Silva dos; FRANCESCANTONIO, Paulo Luiz Carvalho
    Background: The V Brazilian Consensus for determination of autoantibodies against cellular constituents on HEp-2 cells, held in Brasilia (DF, Brazil) on August 27, 2016, discussed the harmonization between the Brazilian Consensus on ANA (BCA) guidelines and the International Consensus on ANA Patterns (ICAP) recommendations (www.anapatterns.org). Initial guidelines were formulated by the group of Brazilian experts with the purpose of guiding and enabling Brazilian clinical laboratories to adopt recommendations and to provide a common standard for national and international consensuses. Mainbody: Twenty Brazilian researchers and experts from universities and clinical laboratories representing the various geographical regions of the country participated in the meeting. Three main topics were discussed, namely the harmonization between the BCA guidelines and latest recommendations of the CAP initiative, the adjustment of the terminology and report on HEp-2 patterns, and a reassessment of quality assurance parameters. For the three topics, our aim was to establish specific guidelines. All recommendations were based on consensus among participants. There was concrete progress in the adjustment of the BCA guidelines to match the ICAP guidelines. To a certain extent, this derives from the fact that ICAP recommendations were largely based on the algorithm and recommendations of the IV Brazilian ANA Consensus, as consistently recognized in the ICAP publications and presentations. However, although there is great overlap between the two Consensuses, there are some point divergences. These specific items were individually and extensively discussed, and it was acknowledged that in several points ICAP improved recommendations previously issued by the Brazilian ANA Consensus and these changes were readily implemented. Regarding some specific topics, the BCA panel of experts felt that the previously issued recommendations remained relevant and possibly will require further discussion with ICAP. The term anti-cell antibodies was adopted as the recommended designation, recognizing that the assay addresses antibodies against antigens in the nucleus and in other cell compartments. However, the acronym ANA HEp-2 was maintained due to historical and regulatory reasons. It was also signalized that the latest trend in ICAP is to adopt the term Indirect Immunofluorescent Assay on HEp-2 cell substrate (HEp-2 IIFA). In addition, the quality assurance strategies previously presented were ratified and emphasized. Conclusion: The V BCA edition was successful in establishing an overall harmonization with the ICAP recommendations for interpretation of the HEp-2 IIFA test, pinpointing the perspectives in filling the remaining gaps between both initiatives.
  • conferenceObject
    ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY IN PRIMARY SJOGREN SYNDROME: A MARKER OF EROSIONS ON HIGH RESOLUTION ULTRASOUND OF HANDS AND WRISTS
    (2019) GUEDES, Lissiane; LEON, Elaine; VENDRAMINI, Margarete; BOCATE, Tamyris; BONFIGLIOLI, Karina; BONFA, Eloisa; PASOTO, Sandra
  • conferenceObject
    Prospective Evaluation of American Academy of Ophthalmology Low Dose Hydroxychloroquine Recommendation in Stable Lupus Nephritis with High-Risk Retinopathy: Lipid Profile and Flare Rates
    (2019) PEDROSA, Tatiana; PASOTO, Sandra G.; YUKI, Emily; AIKAWA, Nadia; BORBA, Eduardo; FERREIRA FILHO, Julio; CARRICONDO, Pedro; ZANETTI, Caio; CONDE, Paola; FONTOURA, Nicole; ROMANO, Paschoalina; CARVALHO, Valdemir; SILVA, Clovis; BONFA, Eloisa