KRISTOPHERSON LUSTOSA AUGUSTO
Projetos de Pesquisa
Unidades Organizacionais
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
bookPart Reumatismo de Partes Moles(2015) PONTES FILHO, Marco Antonio Gonçalves; AUGUSTO, Kristopherson Lustosa; FULLER, RicardoconferenceObject Bone Microarchitecture and Bone Strength in Patients with Primary Sjogren's Syndrome: A Case-Control Study Using HR-pQCT(2015) PASOTO, Sandra Gofinet; AUGUSTO, Kristopherson Lustosa; ALVARENGA, Jackeline Couto; TAKAYAMA, Liliam; CAPARBO, Valeria; OLIVEIRA, Ricardo M.; BONFA, Eloisa; PEREIRA, Rosa M. R.conferenceObject Metabolic Syndrome, Adipocytokines and Inflammation in Sjogren's Syndrome.(2014) AUGUSTO, Kristopherson Lustosa; BONFA, Eloisa; PEREIRA, Rosa M. R.; BUENO, Cleonice; VIANA, Vilma S. T.; PASOTO, Sandra G.bookPart Hiperidrose(2015) VASCONCELLOS, Cidia; AUGUSTO, Kristopherson Lustosa; BARROS, LenôrabookPart Osteoartrite(2015) REPIZO, Liliany; AUGUSTO, Kristopherson Lustosa; FULLER, Ricardo- Metabolic syndrome in Sjogren's syndrome patients: a relevant concern for clinical monitoring(2016) AUGUSTO, Kristopherson Lustosa; BONFA, Eloisa; PEREIRA, Rosa Maria Rodrigues; BUENO, Cleonice; LEON, Elaine Pires; VIANA, Vilma Santos Trindade; PASOTO, Sandra GofinetMetabolic syndrome (MetS) has been described in autoimmune diseases. However, there are scarce data about MetS and adipocytokine profile in primary Sjogren's syndrome (pSS). Seventy-one female pSS patients (American-European Consensus Group Criteria, 2002) aged 18-65 years and 71 age-, race-matched control women were enrolled in this case-control study. Clinical data were collected by a standardized protocol. Blood levels of glucose, cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), triglycerides, interleukin-1beta (IL-1beta)/IL-6, B-cell activating factor (BAFF), insulin, and leptin/adiponectin/visfatin/resistin were determined. Patients and controls were comparable regarding body mass index (BMI), smoking, sedentariness, and menopause (p > 0.05). MetS (39.4 vs. 16.9 %, p = 0.005), hypertension (p = 0.004), and dyslipidemia (p = 0.002) were more frequent in patients than controls. IL-1beta, IL-6, BAFF, resistin, and adiponectin levels were higher in patients than controls (p < 0.05). pSS patients with MetS (n = 28) had higher BMI, waist circumference, cholesterol, LDL-C, triglycerides, insulin, leptin and HOMA-IR values, and greater hypertension and diabetes rates than pSS patients without MetS (n = 43) (p < 0.05). Current and/or previous prednisone use (75.0 vs. 62.8 %, p = 0.313), current (3.0 +/- 4.5 vs. 1.6 +/- 3.2 mg/day, p = 0.299), and cumulative prednisone doses (p = 0.495) were similar in both groups. Otherwise, IL-1beta level was higher in MetS patients than in non-MetS patients (p = 0.012), and this finding was confirmed (p = 0.048) by multivariate analysis with adjustments for age, ethnicity, prednisone use, current and cumulative prednisone doses, and duration of use. We identified high MetS frequency and abnormal adipocytokine profile in pSS. The association of MetS with elevated IL-1beta level suggests that inflammation plays an important role in its pathogenesis.
bookPart Monoartrites(2015) REPIZO, Liliany; AUGUSTO, Kristopherson Lustosa; GARCIA, Maria Lúcia Bueno