LIVEA CARLA FIDALGO GARCEZ SANT'ANA
Projetos de Pesquisa
Unidades Organizacionais
LIM/27 - Laboratório de Neurociências, Hospital das Clínicas, Faculdade de Medicina
2 resultados
Resultados de Busca
Agora exibindo 1 - 2 de 2
bookPart Trantornos cognitivos e comportamentais relacionados ao envelhecimento da pessoa com síndrome de Down(2021) CARVALHO, Cláudia Lopes; SANT'ANA, Livea Carla Fidalgo Garcêz; MARTINEZ, Luana Dongue; RIBEIRO, Octávio Gonçalves; FORLENZA, Orestes Vicente- Balance and Gait Associations With Cognitive Impairment and Dementia in Individuals With Down Syndrome(2023) CONCEICAO, Aline S. G. G.; SANT'ANA, Livea F. G.; MATTAR, Guilherme P.; SILVA, Maria de Fatima R.; RAMOS, Andressa R.; OLIVEIRA, Alexandra M.; CARVALHO, Claudia L.; GONCALVES, Octavio R.; VAROTTO, Bruna L. R.; MARTINEZ, Luana D.; LEDUC, Vinicius; FONSECA, Luciana M.; FORLENZA, Orestes V.Background: Atypical aging in Down syndrome (DS) is associated with neuropathological characteristics consistent with Alzheimer disease. Gait abnormalities have been shown to be associated with an increased risk of dementia for the general population. The aim of this study was to determine whether gait disorders are associated with worse cognitive performance and dementia in adults with DS.Methods: We evaluated 66 individuals with DS (>= 20 y of age), divided into 3 groups: stable cognition, prodromal dementia, and dementia (presumed Alzheimer disease). Each individual was evaluated with the Performance-Oriented Mobility Assessment (POMA), Timed Up and Go test, and Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS), in addition to a comprehensive clinical protocol to ascertain the occurrence of medical or psychiatric comorbidities.Results: The score on the POMA-Gait subscale score and body mass index were found to be independent predictors of prodromal dementia and dementia (P<0.001 for both). With the exception of perception, all cognitive domains correlated with the POMA-Total score (P<0.05).Conclusion: A lower POMA-Gait score increases the chance of prodromal dementia and dementia in adults with DS. Unlike other research, in this study higher body mass index was also found to increase the chance of prodromal dementia and dementia. In those individuals, applying the POMA could facilitate the early diagnosis of dementia, help identify fall risks, and promote the adoption of geriatric interventions focused on improving functional mobility.