MAIRA OKADA DE OLIVEIRA
Projetos de Pesquisa
Unidades Organizacionais
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
6 resultados
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Agora exibindo 1 - 6 de 6
- Inference comprehension from reading in individuals with mild cognitive impairment(2021) SILAGI, Marcela Lima; ROMERO, Vivian Urbanejo; OLIVEIRA, Maira Okada de; TRES, Eduardo Sturzeneker; BRUCKI, Sonia Maria Dozzi; RADANOVIC, Marcia; MANSUR, Leticia LessaInference comprehension is a complex ability that recruits distinct cognitive domains, such as language, memory, attention, and executive functions. Therefore, it might be sensitive to identify early deficits in subjects with MCI. To compare the performance of subjects with mild cognitive impairment (MCI) in an inference reading comprehension task, and to analyze the correlations between inferential comprehension and other cognitive functions. We studied 100 individuals aged 60 and over, divided into MCI (50) [aMCI (35), naMCI (15)], and cognitively healthy individuals [controls (50)]. The Implicit Management Test (IMT) was used to assess inference in reading comprehension in five categories: explicit, logical, distractor, pragmatic, and ""others"". MCI group performed worse than controls in logical, pragmatic, distractor, and ""others"" questions (p < 0.01). The aMCI and naMCI subgroups presented a similar performance in all types of questions (p > 0.05). We observed significant correlations between the total IMT score and the TMT-A in the naMCI group (r = - 0.562, p = 0.036), and the Rey-Osterrieth Complex Figure and RAVLT tasks in the aMCI group (r = 0.474, p = 0.010 and r = 0.593, p = 0.0001, respectively). The MCI group as a whole performed worse than controls on the logical, pragmatic, other and distractor questions, and consequently on the total score. There were no differences in explicit questions, which impose lower inferential demands. The aMCI group suffered a significant impact from memory on inference comprehension, and difficulties in executive functions impacted naMCI performance. The IMT was useful to differentiate MCI patients from cognitively healthy individuals, but not MCI subgroups among themselves.
- Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration(2021) SALAMONE, Paula C.; LEGAZ, Agustina; SEDENO, Lucas; MOGUILNER, Sebastian; FRAILE-VAZQUEZ, Matias; CAMPO, Cecilia Gonzalez; FITTIPALDI, Sol; YORIS, Adrian; MIRANDA, Magdalena; BIRBA, Agustina; GALIANI, Agostina; ABREVAYA, Sofia; NEELY, Alejandra; CARO, Miguel Martorell; ALIFANO, Florencia; VILLAGRA, Roque; ANUNZIATA, Florencia; OLIVEIRA, Maira Okada de; PAUTASSI, Ricardo M.; SLACHEVSKY, Andrea; SERRANO, Cecilia; GARCIA, Adolfo M.; IBANEZ, AgustinRecent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating the priming of emotions via interoception and exploring their multimodal signatures in neurodegenerative models. Here, we designed a novel task that involves interoceptive and control-exteroceptive priming conditions followed by post-interoception and post-exteroception facial emotion recognition (FER). We recruited 114 participants, including healthy controls (HCs) as well as patients with behavioral variant frontotemporal dementia (bvFTD), Parkinson's disease (PD), and Alzheimer's disease (AD). We measured online EEG modulations of the heart-evoked potential (HEP), and associations with both brain structural and resting-state functional connectivity patterns. Behaviorally, post-interoception negative FER was enhanced in HCs but selectively disrupted in bvFTD and PD, with AD presenting generalized disruptions across emotion types. Only bvFTD presented impaired interoceptive accuracy. Increased HEP modulations during post-interoception negative FER was observed in HCs and AD, but not in bvFTD or PD patients. Across all groups, post-interoception negative FER correlated with the volume of the insula and the ACC. Also, negative FER was associated with functional connectivity along the (a) salience network in the post-interoception condition, and along the (b) executive network in the post-exteroception condition. These patterns were selectively disrupted in bvFTD (a) and PD (b), respectively. Our approach underscores the multidimensional impact of interoception on emotion, while revealing a specific pathophysiological marker of bvFTD. These findings inform a promising theoretical and clinical agenda in the fields of nteroception, emotion, allostasis, and neurodegeneration.
- Openness and age influence the progression of mild cognitive impairment(2021) MERLIN, S. S.; OLIVEIRA, M. O. de; CASSIMIRO, L.; AVOLIO, I. B.; BRUCKI, S. M. D.BACKGROUND: The characterization of risk factors for dementia and protective factors for the maintenance of healthy aging remains a relevant area for research. For this reason, the way people interact with the world around them and, therefore, some psychological and personality characteristics of individuals, seem to determine behavioral patterns that are associated with better health throughout life and, consequently, prevent the progression of early cognitive changes to dementia. METHOD: One hundred and two volunteers were evaluated clinically and for personality characteristics and neuropsychological testing. Of these, 25 subjects were classified as cognitively normal (CN), 25 as subjective cognitive decline (SCD), 28 as non-amnestic mild cognitive impairment (naMCI), and 24 as amnestic mild cognitive impairment (amMCI). Follow-up occurred over two years from the initial assessment, and participants' cognitive categories were re-analyzed every six months to observe variation in the same. RESULT: Of the 102 subjects, 65 remained at follow-up. The sample followed up longitudinally was composed predominantly of women (65%), white (74%), with a mean age of 78 (±7.5) years and 12 (±4.8) years of education. Throughout the process, 23% of CN, 15% of DCS, and 27% of CCLNA individuals worsened cognitively. In the same period, 15% of the CCLAM and 31% of the CCLNA improved in cognitive ratings. Using the contingency table to study associations of variables, it was observed that older ages present greater cognitive worsening (p=0.05), and that very low or high indices of the personality trait Openness present associations with cognitive worsening (p=0.005). Probably because the Open extremes are a product of the improper functioning of the Standard Mode Network. CONCLUSION: The factors most associated with cognitive change in this group of elderly were age and the intensity of the Openness aspects of the personality. © 2021 the Alzheimer's Association.
- The impact of COVID-19 on the well-being and cognition of older adults living in the United States and Latin America(2021) BABULAL, Ganesh M.; TORRES, Valeria L.; ACOSTA, Daisy; AGUERO, Cinthya; AGUILAR-NAVARRO, Sara; AMARIGLIO, Rebecca; USSUI, Juliana Aya; BAENA, Ana; BOCANEGRA, Yamile; BRUCKI, Sonia Maria Dozzi; BUSTIN, Julian; CABRERA, Diego M.; CUSTODIO, Nilton; DIAZ, Monica M.; PENAILILLO, Lissette Duque; FRANCO, Idalid; GATCHEL, Jennifer R.; GARZA-NAVEDA, Ana Paola; LARA, Mariana Gonzalez; GUTIERREZ-GUTIERREZ, Lidia; GUZMAN-VELEZ, Edmarie; HANSEEUW, Bernard J.; JIMENEZ-VELAZQUEZ, Ivonne Z.; RODRIGUEZ, Tomas Leon; LLIBRE-GUERRA, Jorge; MARQUINE, Maria J.; MARTINEZ, Jairo; MEDINA, Luis D.; MIRANDA-CASTILLO, Claudia; PAREDES, Alejandra Morlett; MUNERA, Diana; NUNEZ-HERRERA, Alberto; OLIVEIRA, Maira Okada de; PALMER-CANCEL, Santiago J.; PARDILLA-DELGADO, Enmanuelle; PERALES-PUCHALT, Jaime; PLUIM, Celina; RAMIREZ-GOMEZ, Liliana; RENTZ, Dorene M.; RIVERA-FERNANDEZ, Claudia; ROSSELLI, Monica; SERRANO, Cecilia M.; SUING-ORTEGA, Maria Jose; SLACHEVSKY, Andrea; SOTO-ANARI, Marcio; SPERLING, Reisa A.; TORRENTE, Fernando; THUMALA, Daniela; VANNINI, Patrizia; VILA-CASTELAR, Clara; YANEZ-ESCALANTE, Tatiana; QUIROZ, Yakeel T.Background: In the COVID-19 pandemic, older adults from vulnerable ethnoracial groups are at high risk of infection, hospitalization, and death. We aimed to explore the pandemic's impact on the well-being and cognition of older adults living in the United States (US), Argentina, Chile, Mexico, and Peru. Methods: 1,608 (646 White, 852 Latino, 77 Black, 33 Asian; 72% female) individuals from the US and four Latin American countries aged >= 55 years completed an online survey regarding well-being and cognition during the pandemic between May and September 2020. Outcome variables (pandemic impact, discrimination, loneliness, purpose of life, subjective cognitive concerns) were compared across four US ethnoracial groups and older adults living in Argentina, Chile, Mexico, and Peru. Findings: Mean age for all participants was 66.7 (SD = 7.7) years and mean education was 15.4 (SD = 2.7) years. Compared to Whites, Latinos living in the US reported greater economic impact (p < .001, eta(2)(p) = 0.031); while Blacks reported experiencing discrimination more often (p< 001, eta(2)(p) = 0.050).
- Fields of Forel Brain Stimulation Improves Levodopa-Unresponsive Gait and Balance Disorders in Parkinson's Disease(2021) ROCHA, Maria Sheila Guimaraes; FREITAS, Julian Leticia de; COSTA, Carlos Daniel Miranda; OLIVEIRA, Maira Okada de; TERZIAN, Paulo Roberto; QUEIROZ, Joao Welberthon Matos; FERRAZ, Jamana Barbosa; TATSCH, Joao Fellipe Santos; SORIANO, Diogo Coutinho; HAMANI, Clement; GODINHO, FabioBACKGROUND: Gait and balance disturbance are challenging symptoms in advanced Parkinson's disease (PD). Anatomic and clinical data suggest that the fields of Forel may be a potential surgical target to treat these symptoms. OBJECTIVE: To test whether bilateral stimulation centered at the fields of Forel improves levodopa unresponsive freezing of gait (FOG), balance problems, postural instability, and falls in PD. METHODS: A total of 13 patients with levodopa-unresponsive gait disturbance (Hoehn and Yahr stage >= 3) were included. Patients were evaluated before (on-medication condition) and 1 yr after surgery (on-medication-on-stimulation condition). Motor symptoms and quality of life were assessed with the Unified Parkinson's Disease Rating scale (UPDRS III) and Quality of Life scale (PDQ-39). Clinical and instrumented analyses assessed gait, balance, postural instability, and falls. RESULTS: Surgery improved balance by 43% (95% confidence interval [CI]: 21.2-36.4 to 35.2-47.1; P = .0012), reduced FOG by 35% (95% CI: 15.1-20.3 to 8.1-15.3; P = .0021), and the monthly number of falls by 82.2% (95% CI: 2.2-6.9 to -0.2-1.7; P = .0039). Anticipatory postural adjustments, velocity to turn, and postural sway measurements also improved 1 yr after deep brain stimulation (DBS). UPDRS III motor scores were reduced by 27.2% postoperatively (95% CI: 42.6-54.3 to 30.2-40.5; P < .0001). Quality of life improved 27.5% (95% CI: 34.6-48.8 to 22.4-37.9; P = .0100). CONCLUSION: Our results suggest that DBS of the fields of Forel improved motor symptoms in PD, as well as the FOG, falls, balance, postural instability, and quality of life.
- The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science(2021) IBANEZ, Agustin; YOKOYAMA, Jennifer S.; POSSIN, Katherine L.; MATALLANA, Diana; LOPERA, Francisco; NITRINI, Ricardo; TAKADA, Leonel T.; CUSTODIO, Nilton; ORTIZ, Ana Luisa Sosa; AVILA-FUNES, Jose Alberto; BEHRENS, Maria Isabel; SLACHEVSKY, Andrea; MYERS, Richard M.; COCHRAN, J. Nicholas; BRUSCO, Luis Ignacio; BRUNO, Martin A.; BRUCKI, Sonia M. D.; PINA-ESCUDERO, Stefanie Danielle; OLIVEIRA, Maira Okada de; KEHOE, Patricio Donnelly; GARCIA, Adolfo M.; CARDONA, Juan Felipe; SANTAMARIA-GARCIA, Hernando; MOGUILNER, Sebastian; DURAN-ANIOTZ, Claudia; TAGLIAZUCCHI, Enzo; MAITO, Marcelo; IBARROLA, Erika Mariana Longoria; PINTADO-CAIPA, Maritza; GODOY, Maria Eugenia; BAKMAN, Vera; JAVANDEL, Shireen; KOSIK, Kenneth S.; VALCOUR, Victor; MILLER, Bruce L.Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems. The challenges prove particularly pressing for conditions with highly specific diagnostic and management demands, such as frontotemporal dementia. Here we introduce a research and networking initiative designed to tackle these ensuing hurdles, the Multi-partner consortium to expand dementia research in Latin America (ReDLat). First, we present ReDLat's regional research framework, aimed at identifying the unique genetic, social, and economic factors driving the presentation of frontotemporal dementia and Alzheimer's disease in Latin America relative to the US. We describe ongoing ReDLat studies in various fields and ongoing research extensions. Then, we introduce actions coordinated by ReDLat and the Latin America and Caribbean Consortium on Dementia (LAC-CD) to develop culturally appropriate diagnostic tools, regional visibility and capacity building, diplomatic coordination in local priority areas, and a knowledge-to-action framework toward a regional action plan. Together, these research and networking initiatives will help to establish strong cross-national bonds, support the implementation of regional dementia plans, enhance health systems' infrastructure, and increase translational research collaborations across the continent.