WILLIAM OMAR CONTRERAS LOPEZ
Projetos de Pesquisa
Unidades Organizacionais
5 resultados
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- Aesthetically optimal deep brain stimulation technique in patients with alopecia(2015) FONOFF, Erich Talamoni; TEIXEIRA, Manoel Jacobsen; NASCIMENTO, Clarissa Nobrega Gambarra; LOPEZ, William Omar
- Clinical neurotransplantation protocol for Huntington's and Parkinson's disease(2013) LOPEZ, William Omar Contreras; NIKKHAH, Guido; KAHLERT, Ulf D.; MACIACZYK, Donata; BOGIEL, Tomasz; MOELLERS, Sven; SCHUELTKE, Elisabeth; DOEBROESSY, Mate; MACIACZYK, JaroslawPurpose: The concept of transplantation of neuronal cells to treat Huntington's and Parkinson's diseases is based on the proven principle that dopaminergic and GABA-ergic progenitor neurons (from the human developing ventral mesencephalon and whole ganglionic eminence) can survive, differentiate and functionally integrate into an allogenic host brain. However, several donor and host-specific variables play a major role in the safety and outcome of this procedure. In this paper, we seek to summarize an updated neural transplantation protocol, based on our institutional experience and many years of collaboration with other neurotransplantation centers. Methods: We present a detailed clinical neurotransplantation protocol for Parkinson's (PD) and Huntington's (HD) diseases with special emphasis in understanding the anatomical relationships of the human fetal tissue that are relevant for selection of the desired cell populations. Results: Two detailed step-wise neurotransplantation protocols are presented, outlining strategies facilitating the avoidance of possible procedure-related complications. Conclusions: In this paper we delineated some crucial technical factors enabling the execution of a safe and effective neural transplantation. The protocols presented here might contribute to further development of the experimental clinical neurotransplantation towards a routine therapeutic procedure.
conferenceObject Treatment of Complex Regional Pain Syndrome type II (CRPS-II) with Simultaneous Multi-Target Spinal Cord and Motor Cortex Stimulation: A Case Report(2016) VELEZ, Faddi G. Saleh; DURAN, Juanita; FONOFF, Erich T.; CONTRERAS, William O.- Embryonic stem cells in neurology - current clinical transplantation trials in Parkinson's (PD) and Huntington's (HD) disease(2014) LOPEZ, William Omar Contreras; NIKKHAH, Guido; MACIACZYK, Jaroslaw
- Listenmee (R) and Listenmee (R) smartphone application: Synchronizing walking to rhythmic auditory cues to improve gait in Parkinson's disease(2014) LOPEZ, William Omar Contreras; HIGUERA, Carlos Andres Escalante; FONOFF, Erich Talamoni; SOUZA, Carolina de Oliveira; ALBICKER, Ulrich; MARTINEZ, Jairo Alberto EspinozaEvidence supports the use of rhythmic external auditory signals to improve gait in PD patients (Arias 82 Cudeiro, 2008; Kenyon & Thaut, 2000; McIntosh, Rice & Thaut, 1994; McIntosh et al., 1997; Morris, lansek, & Matyas, 1994; Thaut, McIntosh, 82 Rice, 1997; Suteerawattananon, Morris, Etnyre, Jankovic, & Protas, 2004; Willems, Nieuwboer, Chavert, & Desloovere, 2006). However, few prototypes are available for daily use, and to our knowledge, none utilize a smartphone application allowing individualized sounds and cadence. Therefore, we analyzed the effects on gait of Listenmee (R), an intelligent glasses system with a portable auditory device, and present its smartphone application, the Listenmee app (R), offering over 100 different sounds and an adjustable metronome to individualize the cueing rate as well as its smartwatch with accelerometer to detect magnitude and direction of the proper acceleration, track calorie count, sleep patterns, steps count and daily distances. The present study included patients with idiopathic PD presented gait disturbances including freezing. Auditory rhythmic cues were delivered through Listenmee (R). Performance was analyzed in a motion and gait analysis laboratory. The results revealed significant improvements in gait performance over three major dependent variables: walking speed in 38.1%, cadence in 28.1% and stride length in 44.5%. Our findings suggest that auditory cueing through Listenmee (R) may significantly enhance gait performance. Further studies are needed to elucidate the potential role and maximize the benefits of these portable devices.