MARIA LUIZA BAGGIO GARCIA PINTO
Índice h a partir de 2011
12
Projetos de Pesquisa
Unidades Organizacionais
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
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- Country-specific HPV-related genital disease among men residing in Brazil, Mexico and The United States: The HIM study(2017) SUDENGA, Staci L.; TORRES, B. Nelson; FULP, William J.; SILVA, Roberto; VILLA, Luisa L.; LAZCANO-PONCE, Eduardo; INGLES, Donna J.; STOLER, Mark; MESSINA, Jane L.; ABRAHAMSEN, Martha; BAGGIO, Maria Luiza; SALMERON, Jorge; QUITERIO, Manuel; GIULIANO, Anna R.The purpose of this study was to assess whether the incidence of histopathologically confirmed condyloma and penile intraepithelial neoplasia (PeIN) and rates of genital HPV infection progression to these lesions differs by country (Brazil, Mexico and the U.S.). At each visit, lesions were biopsied and were categorized by pathologic diagnoses. The Linear Array genotyping method was used to identify HPV genotypes from genital swabs, while the INNO-LiPA HPV Genotyping Extra method was used for tissue specimens. Age-specific analyses were conducted for lesion incidence by country, with Kaplan-Meier estimation of cumulative incidence. The proportion of HPV infections that progressed to condyloma and PeIN, the median time to lesion development and the incidence rates were estimated by country. When comparing demographic and sexual characteristics across the three countries, sexual orientation (p = 0.008) and lifetime number of female sexual partners (p < 0.0001) were differentially associated with lesion incidence in the three countries. Condyloma incidence in Brazil and the U.S. decreased with age, while incidence remained constant across the lifespan in Mexico. There were no differences by country and age for PeIN incidence. HPV types 6 and 11 were the most common types to progress to condyloma and HPV types 16, 6 and 11 were the most common types to progress to PeIN in all three countries. The continuous risk of condyloma and PeIN across all age groups and countries in this study emphasizes the need to ensure that strong HPV immunity, such as that obtained through vaccination, is maintained across the lifespan of men.
- Dietary intake of selected nutrients and persistence of HPV infection in men(2017) LOPES, Raissa do Vale C.; TEIXEIRA, Juliana A.; MARCHIONI, Dirce; VILLA, Luisa L.; GIULIANO, Anna R.; BAGGIO, Maria Luiza; FISBERG, Regina M.Human papillomavirus (HPV) infection is a common sexually transmitted disease. Although often transitory, persistent oncogenic HPV infection may progress to a precursor lesion and, if not treated, can further increase the risk of cancer. The purpose of this study was to investigate the relation between dietary intake and HPV persistent infection in men of a Brazilian cohort. The study population consisted of 1,248 men from the Brazilian cohort of the HIM (HPV in Men) Study, ages 18 to 70 years, who completed a quantitative food frequency questionnaire. U Mann-Whitney test was used to assess differences in median nutrient intake of selected nutrients. The association of dietary intake and persistent HPV infection was assessed in multivariate logistic models. The prevalence of any HPV infection at baseline was 66.6%. Of 1,248 participants analyzed, 1,211 (97.0%) were HPV positive at one or more times during the 4 years of follow-up and 781 (62.6%) were persistently HPV positive. Men with nonpersistent oncogenic HPV infections had higher median intake of retinol (p=0.008), vitamin A (p<0.001) and folate (DFE; p=0.003) and lower median intake of energy (p=0.005) and lycopene (p=0.008) in comparison to men with persistent oncogenic infections. No significant association was found between selected nutrients and persistent oncogenic HPV infection. For nononcogenic persistent infections, only vitamin B12 intake was significantly associated (p=0.003, test for trend). No association was observed between dietary intake and persistent oncogenic-type HPV infection; however, vitamin B12 intake was inversely associated with nononcogenic HPV persistence. What's new? Can diet influence the persistence of HPV infection? Certain B vitamins, for instance, can promote viral integration, while other nutrients hinder it. This is the first study to investigate whether diet contributes to persistent oncogenic HPV-infection in men. Looking at a Brazilian cohort of men age 18-70, these authors tested the men for HPV over a period of 4 years. At each meeting, they gave them a questionnaire, asking about their diet. Persistent nononcogenic HPV infection was associated with B12 consumption, they found, but they could link none of the nutrients to persistent oncogenic HPV infection.
- Sequential acquisition of human papillomavirus infection between genital and oral anatomic sites in males(2021) DICKEY, Brittney L.; FAN, Wenyi; BETTAMPADI, Deepti; REICH, Richard R.; SIRAK, Bradley; ABRAHAMSEN, Martha; BAGGIO, Maria Luiza; GALAN, Lenice; SILVA, Roberto Carvalho; SALMERON, Jorge; VILLA, Luisa L.; LAZCANO-PONCE, Eduardo; GIULIANO, Anna R.Oral human papillomavirus (HPV) is associated with increasing rates of HPV-associated oropharyngeal cancer (OPC) in men. Sequential infection from one site to another has been demonstrated at the cervix and anus. Thus, risk of an oral HPV infection after a genital infection of the same type in the HPV infection in men study was investigated. Samples from 3140 men enrolled in a longitudinal cohort were assessed for sequential genital to oral infection with one of nine HPV types (HPV 6, 11, 16, 18, 31, 33, 45, 52 and 58); and then also sequential, same-type oral to genital infection. Incidence rate ratios (IRRs) compared rates of oral HPV among men with and without prior genital infection of the same type. Risk of sequential HPV infections were assessed using Cox proportional hazards model. Incidence of an oral HPV infection was significantly higher among men with a prior genital infection of the same type for any of the 9 HPV types (IRR: 2.3; 95% CI: 1.7-3.0). Hazard ratio of a sequential genital to oral HPV infection was 2.3 (95% CI: 1.7-3.1) and 3.5 (95% CI: 1.9-6.4) for oral to genital infection. Both changed minimally after adjustment for age, country, circumcision, alcohol use, lifetime sexual partners and recent oral sex partners. HPV infections at one site could elevate risk of a subsequent genital or oral HPV infection of the same type in men, emphasizing the importance of vaccination to prevent all HPV infections.