CAMILA NASCIMENTO MANTELLI
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
conferenceObject Brain transcriptome analysis of Japanese population living in Brazil(2019) MARIE, Suely Kazue Nagahashi; LERARIO, Antonio Marcondes; SHINJO, Sueli Mieko Oba; NASCIMENTO, Camila; LEITE, Renata; SUEMOTO, Claudia; PASQUALUCCI, Carlos Augusto; MURAYAMA, Shigeo- A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia(2019) NASCIMENTO, Camila; NUNES, Paula Villela; RODRIGUEZ, Roberta Diehl; TAKADA, Leonel; SUEMOTO, Claudia Kimie; GRINBERG, Lea Tenenholz; NITRINI, Ricardo; LAFER, BenyMental disorders are highly prevalent and important causes of medical burden worldwide. Co-occurrence of neurological and psychiatric symptoms are observed among mental disorders, representing a challenge for their differential diagnosis. Psychiatrists and neurologists have faced challenges in diagnosing old adults presenting behavioral changes. This is the case for early frontotemporal dementia (FTD) and bipolar disorder. In its initial stages, FTD is characterized by behavioral or language disturbances in the absence of cognitive symptoms. Consequently, patients with the behavioral subtype of FTD (bv-FTD) can be initially misdiagnosed as having a psychiatric disorder, typically major depression disorder (MDD) or bipolar disorder (BD). Bipolar disorder is associated with a higher risk of dementia in older adults and with cognitive impairment, with a subset of patients presents a neuroprogressive pattern during the disease course. No mendelian mutations were identified in BD, whereas three major genetic causes of FTD have been identified. Clinical similarities between BD and bv-FTD raise the question whether common molecular pathways might explain shared clinical symptoms. Here, we reviewed existing data on clinical and molecular similarities between BD and FTD to propose biological pathways that can be further investigated as common or specific markers of BD and FTD.
- Unrevealing the role of a frontotemporal dementia protein (TDP-43 protein) in bipolar disorder(2019) NASCIMENTO, C.; VILLELA, P. Nunes; KIM, H. Kyunghee; OLIVEIRA, K. De; LEITE, R. E. Paraizo; FERRETTI-REBUSTINI, R. E. D. L.; GRINBERG, L. T.; SUEMOTO, C. K.; PASQUALUCCI, C. A.; NITRINI, R.; JACOB-FILHO, W.; BRENTANI, H. P.; LAFER, B.
conferenceObject Increased levels of cortisol but not C-reactive protein in different brain regions in bipolar disorder: a post-mortem study(2019) NUNES, P. V.; NASCIMENTO, C.; SUEMOTO, C. K.; RODRIGUEZ, R. D.; LEITE, R. E. P.; FERRETTI-REBUSTINI, R. E. delucena; GRINBERG, L. T.; PASQUALUCCI, C. A.; NITRINI, R.; JACOB-FILHO, W.; BRENTANI, H. P.; LAFER, B.- Low brain-derived neurotrophic factor levels in post-mortem brains is associated with sub-syndromic neuropsychiatric symptoms(2019) NUNES, P. V.; NASCIMENTO, C. F.; KIM, H. K.; ANDREAZZA, A.; BRENTANI, H. P.; SUEMOTO, C. K.; LEITE, R. E. P.; FERRETTI-REBUSTINI, R. E. D. L.; PASQUALUCCI, C. A.; NITRINI, R.; GRINBERG, L. T.; YOUNG, L. T.; JACOB-FILHO, W.; LAFER, B.
conferenceObject Late life depression in cases without dementia is associated to vascular lesions and Lewy Body pathology but not Alzheimer pathology in a large community sample neuropathological study(2019) NUNES, P. V.; SUEMOTO, C. K.; RODRIGUEZ, R. D.; FERRETTI-REBUSTINI, E. de Lucena; LEITE, R. E. P.; NASCIMENTO, F.; SALDANHA, N. M.; PASQUALUCCI, C. A.; NITRINI, R.; GRINBERG, L. T.; JACOB-FILHO, W.; LAFER, B.conferenceObject Imbalanced levels of pro and anti-inflammatory cytokines across different brain regions in bipolar disorder: A post-mortem study(2019) NASCIMENTO, C.; NUNES, P. V.; SUEMOTO, C. K.; RODRIGUEZ, R. D.; LEITE, R. E. P.; FERRETTI-REBUSTINI, R. E. delucena; GRINBERG, L. T.; PASQUALUCCI, C. A.; NITRINI, R.; JACOB-FILHO, W.; BRENTANI, H. P.; LAFER, B.