GIULIANO BETONI GUGLIELMETTI
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina
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- Correlation of a microRNA expression profile and the prognosis of penile cancer: A prospective study using microarray data analysis(2018) FURUYA, Tatiane K.; MURTA, Claudio B.; PONTES JR., Jose; UNO, Miyuki; CARRASCO, Alexis; SICHERO, Laura C.; VILLA, Luisa L.; COELHO, Rafael F.; GUGLIELMETTI, Giuliano B.; CORDEIRO, Mauricio D.; LEITE, Katia R.; SROUGI, Miguel; CHAMMAS, Roger; NAHAS, William C.
- Predictive factors for prolonged hospital stay after retropublic radical prostatectomy in a high-volume teaching center(2018) COELHO, Rafael F.; CORDEIRO, Mauricio D.; PADOVANI, Guilherme P.; LOCALLI, Rafael; FONSECA, Limirio; PONTES JUNIOR, Jose; GUGLIELMETTI, Giuliano B.; SROUGI, Miguel; NAHAS, William CarlosObjective: To evaluate the length hospital stay and predictors of prolonged hospitalization after RRP performed in a high-surgical volume teaching institution, and analyze the rate of unplanned visits to the office, emergency care, hospital readmissions and perioperative complications rates. Materials and Methods: Retrospective analysis of prospectively collected data in a standardized database for patients with localized prostate cancer undergoing RRP in our institution between January/2010 - January/2012. A logistic regression model including preoperative variables was initially built in order to determine the factors that predict prolonged hospital stay before the surgical procedure; subsequently, a second model including both pre and intraoperative variables was analyzed. Results: 1011 patients underwent RRP at our institution were evaluated. The median hospital stay was 2 days, and 217 (21.5%) patients had prolonged hospitalization. Predictors of prolonged hospital stay among the preoperative variables were ICC (OR. 1.40 p=0.003), age (OR 1.050 p<0.001), ASA score of 3 (OR. 3.260 p<0.001), prostate volume on USG-TR (OR, 1.005 p=0.038) and African-American race (OR 2.235 p=0.004); among intra and postoperative factors, operative time (OR 1.007 p=0.022) and the presence of any complications (OR 2.013 p=0.009) or major complications (OR 2.357 p=0.01) were also correlated independently with prolonged hospital stay. The complication rate was 14.5%. Conclusions: The independent predictors of prolonged hospitalization among preoperative variables were CCI, age, ASA score of 3, prostate volume on USG-TR and African-American race; amongst intra and postoperative factors, operative time, presence of any complications and major complications were correlated independently with prolonged hospital stay.
conferenceObject Performance status (PS) in advanced germ cell tumors (aGCT): Clinical and prognostic value of an underreported important variable.(2018) VASCONCELLOS, Vitor Fiorin de; BASTOS, Diogo Assed; PEREIRA, Allan Andresson Lima; PEREIRA, Bruno Rodriguez; SILVA, Jamile Almeida; MUNIZ, David Queiroz Borges; GUGLIELMETTI, Giuliano; NAHAS, William Carlos; DZIK, Carlos- Can tumor contact length predict extracapsular extension, lymph node involvement, and biochemical recurrence?(2018) VIANA, Publio; RODRIGUES, Thiana; PACHANI, Danilo; HORVAT, Natally; CARVALHO, Arnaldo Fazoli; GUGLIELMETTI, Giuliano; COELHO, Rafael; BASTOS, Diogo Assed; NAHAS, William Carlos
conferenceObject IMPACT OF CAMERA DEVIATION ON CURVATURE ASSESSMENTS USING GONIOMETER AND 2D PHOTOGRAPHIES(2018) NASCIMENTO, Bruno; CERQUEIRA, Ivan; MIRANDA, Eduardo P.; BESSA JR., Jose; FIDELIS, Renato; GUGLIELMETTI, Giuliano; BATAGELO, Carlos; SILVA, Gabriel C.; NAHAS, William; SROUGI, Miguel; CHIESA, Giorgio; CURY, Jose- Clinical characteristics and treatment outcomes of patients (pts) with advanced germ cell tumor (aGCT) treated at a tertiary cancer center in Brazil.(2018) VASCONCELLOS, Vitor Fiorin de; BASTOS, Diogo Assed; PEREIRA, Allan Andresson Lima; PEREIRA, Bruno Rodriguez; SILVA, Jamile Almeida; MUNIZ, David Queiroz Borges; GUGLIELMETTI, Giuliano; NAHAS, William Carlos; DZIK, Carlos
- Impact of Camera Deviation on Penile Curvature Assessment Using 2D Pictures(2018) NASCIMENTO, Bruno; CERQUEIRA, Ivan; MIRANDA, Eduardo P.; BESSA JR., Jose; IVANOVIC, Renato F.; GUGLIELMETTI, Giuliano; NAHAS, William C.; SROUGI, Miguel; CHIESA, Giorgio A. E.; CURY, JoseBackground: An accurate curvature assessment (CA) is required in the decision-making process for patients with Peyronie's disease. In-office CA following induced erection is the gold standard for CA, although penile photography is commonly used due to its convenience. Camera deviations during 2D image acquisition might affect CA accuracy. Aim: To investigate the impact of camera angle deviations on CA. Methods: 2D pictures were taken from 5 models with a known uniplanar curvature (40 degrees, 45 degrees, 60 degrees, 90 degrees, and 120 degrees). The model was kept on a fixed point and the camera was rotated around it. Pictures were taken with every 10 degrees increase in camera deviation from the optimal position. The camera rotated to a maximum of 90 degrees deviation in both the vertical and horizontal planes. The pictures were analyzed by 2 different urologists using a goniometer. The expected apparent curvature (AC) and the corresponding picture assessment error (PAE = AC - real model curvature) were also calculated for each picture using trigonometry principles. Main Outcome Measure: Assessing PAE magnitude and patterns was our primary outcome. Secondary outcomes were intraobserver, interobserver, and observer-AC intraclass correlation coefficient (ICC). Results: 100 pictures were analyzed. Intraobserver reliability was high (ICC = 0.99) for both urologists. Interobserver and observer-AC correlation were also high (ICC = 0.996 and ICC = 0.992, respectively). When the camera rotated in the horizontal axis, the PAE underestimated the curvature for models with curvatures smaller than 90 degrees and overestimated the reading of the 120 degrees model. When the camera rotated in the vertical axis, PAE had an inverse effect. The PAE showed a tendency to increase exponentially with higher deviation, reaching almost 100% for a deviation of 80 degrees. Nevertheless, analyzing its magnitude regardless of the curvature, PAE was always <5% for camera deviations of 0-20 degrees. Clinical Implications: If using picture-based CA, clinicians should attempt to take a picture perpendicular to the curvature plane for the most accurate measurement in degrees. Many clinicians request that patients take 3 pictures in a standard fashion (craniocaudal, lateral, and frontal), and if this technique is to be used, an extra picture is recommended. Strength & Limitations: In our controlled environment, we were able to isolate CA errors due to camera angles from other confounders such as erection hardness. As a consequence, however, our results cannot be easily generalized. Conclusion: PAE due to non-optimal camera position is a complex phenomenon that affects CA depending on the rotation axis and the degree of penile curvature. Nevertheless, PAE is always <5% for camera deviations of 0-20 degrees
- Current concepts in multiparametric magnetic resonance imaging for active surveillance of prostate cancer(2018) CAVALCANTE, Alexandre; VIANA, Publio Cesar C.; GUGLIELMETTI, Giuliano B.; PONTES, Jose; NONEMACHER, Henrique; CORDEIRO, Mauricio D.; BEZERRA, Regis Otaviano F.; COELHO, Rafael F.; NAHAS, William Carlos
- IMPACT OF CAMERA DEVIATION ON CURVATURE ASSESSMENTS USING GONIOMETER AND 2D PHOTOGRAPHIES(2018) NASCIMENTO, B.; CERQUEIRA, I; MIRANDA, E.; BESSA, J.; FIDELIS, R.; GUGLIELMETTI, G.; BATAGELO, C.; SILVA, G.; NAHAS, W.; SROUGI, M.; CHIESA, G.; CURY, J.
- Recurrent Penile Fracture-Case Report and Alternative Surgical Approach(2018) NASCIMENTO, Bruno; GUGLIELMETTI, Giuliano B.; MIRANDA, Eduardo P.; IVANOVIC, Renato F.; BATAGELLO, Carlos A.; NAHAS, William C.; SROUGI, Miguel; CURY, JoseIntroduction: Penile refracture is an exceedingly rare event, with very few published studies. To the best of our knowledge, this is the first documented case in the literature of penile fracture with 3 same-site recurrences. Aims: To describe the case of a 25-year-old Caucasian man with recurrent penile fracture ultimately treated with resuture and patch reinforcement. Methods: Patient history (clinical and surgical) and literature review. Results: After the 3rd same-site recurrence, patch reinforcement over the sutured area was performed. The patient had an uneventful recovery and no recurrences to date. Conclusion: There is no evidence indicating the superiority of non-absorbable sutures. Bovine pericardium reinforcement over the sutured area was used to minimize the chance of another recurrence. More studies are necessary to investigate its safety and efficacy in this scenario.