LUIZ APARECIDO BORTOLOTTO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Sao Paulo call to action for the prevention and control of high blood pressure, 2020(2021) CAMPBELL, Norm R. C.; SCHUTTE, Aletta E.; VARGHESE, Cherian V.; ORDUNEZ, Pedro; ZHANG, Xin-Hua; KHAN, Taskeen; SHARMAN, James E.; WHELTON, Paul K.; PARATI, Gianfranco; WEBER, Michael A.; ORIAS, Marcelo; JAFFE, Marc G.; MORAN, Andrew E.; PLAVNIK, Frida Liane; RAM, Venkata S.; BRAININ, Michael; OWOLABI, Mayowa O.; RAMIREZ, Agustin J.; BARBOSA, Eduardo; BORTOLOTTO, Luiz Aparecido; LACKLAND, Daniel T.Cerca de ¼ dos adultos têm hipertensão arterial, que é o fator de risco isolado mais importante para morte (incluídas as mortes por cardiopatia e acidente vascular cerebral). • Existem políticas eficazes que poderiam facilitar escolhas pessoais saudáveis para evitar a elevação da pressão arterial e, se plenamente implementadas, podem prevenir a ocorrência da hipertensão arterial. • É fácil rastrear e tratar a hipertensão, MAS somente cerca de 50% dos adultos hipertensos estão cientes de sua condição, e apenas cerca de 1 em cada 7 é tratado adequadamente. • A prevenção e controle da hipertensão é o principal mecanismo de prevenção e controle das doenças não transmissíveis e um modelo para outros riscos de doenças não transmissíveis. • Tratamentos eficazes com mudanças de estilo de vida e medicamentos poderiam prevenir e controlar a hipertensão arterial na maioria das pessoas se aplicados sistematicamente à população; as intervenções simples são viáveis em todos os ambientes e podem melhorar a atenção primária. • É necessária a ação continuada e urgente a fim de obter mudanças efetivas nas políticas públicas e no sistema de saúde para prevenir e controlar a hipertensão arterial.
- 1st Brazilian Positioning on the Impact of Sleep Disorders on Cardiovascular Diseases of the Brazilian Society of Cardiology(2018) DRAGER, Luciano E.; LORENZI-FILHO, Geraldo; CINTRA, Fatima Dumas; PEDROSA, Rodrigo P.; BITTENCOURT, Lia R. A.; POYARES, Dalva; CARVALHO, Carolina Gonzaga; MOURA, Sonia Maria Guimaraes Pereira Togeiro; SANTOS-SILVA, Rogerio; BRUIN, Pedro F. C. de; GEOVANINI, Glaucylara R.; ALBUQUERQUE, Felipe N.; OLIVEIRA, Vvercules Antonio Alves de; MOREIRA, Gustavo A.; UENO, Linda Massako; NERBASS, Flavia Baggio; RONDON, Maria Urbana Pinto Brandao; BARBOSA, Fine Rozaria Ferreira; BERTOLAMI, Adriana; PAOLA, Angelo Amato Vincenzo de; MARQUES, Betania Braga Silva; RIZZI, Camila Futado; NEGRAO, Carlos Eduardo; UCHOA, Carlos Henrique Gomes; MAKI-NUNES, Cristiane; MARTINEZ, Denis; FERNANDEZ, Edmundo Arteaga; MAROJA, Fabrizio U.; ALMEIDA, Fernanda R.; TROMBETTA, Ivani C.; STORTI, Luciana J.; BORTOLOTTO, Luiz Aparecido; MELLO, Marco Tulio de; BORGES, Melania Aparecida; ANDERSEN, Monica Levy; PORTILHO, Natanael de Paula; MACEDO, Paula; ALVES, Rosana; TUFIK, Sergio; FAGONDES, Simone C.; RISSO, Thais Telles
- Sao Paulo call to action for the prevention and control of high blood pressure: 2020(2019) CAMPBELL, Norm R. C.; SCHUTTE, Aletta E.; VARGHESE, Cherian V.; ORDUNEZ, Pedro; ZHANG, Xin-Hua; KHAN, Taskeen; SHARMAN, James E.; WHELTON, Paul K.; PARATI, Gianfranco; WEBER, Michael A.; ORIAS, Marcelo; JAFFE, Marc G.; MORAN, Andrew E.; PLAVNIK, Frida Liane; RAM, Venkata S.; BRAININ, Michael; OWOLABI, Mayowa O.; RAMIREZ, Augstin J.; BARBOSA, Eduardo; BORTOLOTTO, Luiz Aparecido; LACKLAND, Daniel T.
- Obstructive Sleep Apnea The Most Common Secondary Cause of Hypertension Associated With Resistant Hypertension(2011) PEDROSA, Rodrigo P.; DRAGER, Luciano F.; GONZAGA, Carolina C.; SOUSA, Marcio G.; PAULA, Lilian K. G. de; AMARO, Aline C. S.; AMODEO, Celso; BORTOLOTTO, Luiz A.; KRIEGER, Eduardo M.; BRADLEY, T. Douglas; LORENZI-FILHO, GeraldoRecognition and treatment of secondary causes of hypertension among patients with resistant hypertension may help to control blood pressure and reduce cardiovascular risk. However, there are no studies systematically evaluating secondary causes of hypertension according to the Seventh Joint National Committee. Consecutive patients with resistant hypertension were investigated for known causes of hypertension irrespective of symptoms and signs, including aortic coarctation, Cushing syndrome, obstructive sleep apnea, drugs, pheochromocytoma, primary aldosteronism, renal parenchymal disease, renovascular hypertension, and thyroid disorders. Among 125 patients (age: 52 +/- 1 years, 43% males, systolic and diastolic blood pressure: 176 +/- 31 and 107 +/- 19 mm Hg, respectively), obstructive sleep apnea (apnea-hypopnea index: >15 events per hour) was the most common condition associated with resistant hypertension (64.0%), followed by primary aldosteronism (5.6%), renal artery stenosis (2.4%), renal parenchymal disease (1.6%), oral contraceptives (1.6%), and thyroid disorders (0.8%). In 34.4%, no secondary cause of hypertension was identified (primary hypertension). Two concomitant secondary causes of hypertension were found in 6.4% of patients. Age >50 years (odds ratio: 5.2 [95% CI: 1.9-14.2]; P < 0.01), neck circumference >= 41 cm for women and >= 43 cm for men (odds ratio: 4.7 [95% CI: 1.3-16.9]; P = 0.02), and presence of snoring (odds ratio: 3.7 [95% CI: 1.3-11]; P = 0.02) were predictors of obstructive sleep apnea. In conclusion, obstructive sleep apnea appears to be the most common condition associated with resistant hypertension. Age >50 years, large neck circumference measurement, and snoring are good predictors of obstructive sleep apnea in this population. (Hypertension. 2011;58:811-817.). Online Data Supplement
- Sao Paulo call to action for the prevention and control of high blood pressure: 2020(2021) CAMPBELL, Norm R. C.; SCHUTTE, Aletta E.; VARGHESE, Cherian V.; ORDUNEZ, Pedro; ZHANG, Xin-Hua; KHAN, Taskeen; SHARMAN, James E.; WHELTON, Paul K.; PARATI, Gianfranco; WEBER, Michael A.; ORIAS, Marcelo; JAFFE, Marc G.; MORAN, Andrew E.; PLAVNIK, Frida Liane; RAM, Venkata S.; BRAININ, Michael; OWOLABI, Mayowa O.; RAMIREZ, Agustin J.; BARBOSA, Eduardo; BORTOLOTTO, Luiz Aparecido; LACKLAND, Daniel T.About 1/4th of adults have high blood pressure which is the single most important risk for death (including heart disease and stroke). There are effective policies that could facilitate people making healthy choices to prevent raised blood pressure, and if fully implemented, could largely prevent hypertension from occurring. Hypertension is easy to screen and treat for BUT only about 50% of adults with hypertension are aware of their condition and only about 1 in 7 is adequately treated. Preventing and controlling high blood pressure is the major mechanism for NCD prevention and control and a model for other NCD risks. Effective lifestyle and drug treatments could prevent and control hypertension in most individuals if systematically applied to the population, simple interventions are feasible in all settings, and can be used to enhance primary care. Urgent sustained action is needed is needed for effective public policies and health system changes to prevent and control hypertension.
- Reference intervals for common carotid intima-media thickness measured with echotracking: relation with risk factors(2013) ENGELEN, Lian; FERREIRA, Isabel; STEHOUWER, Coen D.; BOUTOUYRIE, Pierre; LAURENT, Stephane; BOUTOUYRIE, Pierre; LAURENT, Stephane; JOUVEN, Xavier; EMPANA, Jean-Philippe; BOZEC, Erwan; SIMON, Tabassome; PANNIER, Bruno; MATTACE-RASO, Francesco U. S.; HOFMAN, Albert; FRANCO, Oscar H.; KAVOUSI, Maryam; ROOIJ, Frank J. van; WITTEMAN, Jacqueline; RIETZSCHEL, Ernst; VERMEERSCH, Sebastian; SEGERS, Patrick; BORTEL, Luc Van; BACQUER, Dirk De; DAELE, Caroline Van; BUYZERE, Marc De; BOTS, Michiel L.; SCHOUW, Yvonne T. van der; GROBBEE, Diederick E.; UITERWAAL, Cuno S.; EVELEIN, Annemieke; GRAAF, Yolanda van der; VISSEREN, Frank L. J.; STEHOUWER, Coen; FERREIRA, Isabel; DEKKER, Jacqueline; NIJPELS, Giel; TWISK, Jos; SMULDERS, Yvo; SCHALKWIJK, Casper; GREEVENBROEK, Marleen van; KALLEN, Carla van der; LAAR, Roel van de; FESKENS, Edith; STAESSEN, Jan; THIJS, Lutgarde; KOUZNETSOVA, Tatyana; JIN, Yu; LIU, Yanping; BENETOS, Athanase; LABAT, Carlos; LACOLLEY, Patrick; WANG, Jiguang; LI, Yan; FISCHER, Joachim; TERRIS, Darcey; JARCZOK, Marc; THOLE, Maren; HEUTEN, Hilde; GOOVAERTS, Inge; ENNEKENS, Guy; VRINTS, Christiaan; RYLISKYTE, Ligita; LAUCEVICIUS, Aleksandras; RYLISKIENE, Kristina; KUZMICKIENE, Jurgita; BIANCHINI, Elisabetta; GHIADONI, Lorenzo; BRUNO, Rosa Maria; CARTONI, Giulia; TADDEI, Stefano; TOLEZANI, Elaine C.; HONG, Valeria; BORTOLOTTO, Luiz; VERMEER, Cees; BRAAM, Lavienja; KNAPEN, Marjo; DRUMMEN, Nadja; RIMOLDI, Stefano F.; STUCKI, Fabian; HUTTER, Damian; REXHAJ, Emrush; FAITA, Francesco; SARTORI, Claudio; SCHERRER, Urs; ALLEMANN, Yves; DELAHOUSSE, Michel; KARRAS, Alexandre; GIANNATTASIO, Cristina; CESANA, Francesca; NAVA, Stefano; MALOBERTI, Alessandro; KOLLAI, Mark; PINTER, Alexandra; HORVATH, Tamas; NARKIEWICZ, Krzysztof; SZYNDLER, Anna; HOFFMANN, Michal; NOWAK, Robert; POLONIS, Katarzyna; THUILLEZ, Christian; JOANNIDES, Robinson; BELLIEN, Jeremy; ANGEL, Kristin; ATAR, Dan; FILIPOVSKY, Jan; AGHARAZII, Mohsen; BRIET, MarieAims Common carotid artery intima-media thickness (CCIMT) is widely used as a surrogate marker of atherosclerosis, given its predictive association with cardiovascular disease (CVD). The interpretation of CCIMT values has been hampered by the absence of reference values, however. We therefore aimed to establish reference intervals of CCIMT, obtained using the probably most accurate method at present (i.e. echotracking), to help interpretation of these measures. Methods and results We combined CCIMT data obtained by echotracking on 24 871 individuals (53 men; age range 15-101 years) from 24 research centres worldwide. Individuals without CVD, cardiovascular risk factors (CV-RFs), and BP-, lipid-, and/or glucose-lowering medication constituted a healthy sub-population (n = 4234) used to establish sex-specific equations for percentiles of CCIMT across age. With these equations, we generated CCIMT Z-scores in different reference sub-populations, thereby allowing for a standardized comparison between observed and predicted (normal) values from individuals of the same age and sex. In the sub-population without CVD and treatment (n = 14 609), and in men and women, respectively, CCIMT Z-scores were independently associated with systolic blood pressure [standardized s 0.19 (95 CI: 0.16-0.22) and 0.18 (0.15-0.21)], smoking [0.25 (0.19-0.31) and 0.11 (0.04-0.18)], diabetes [0.19 (0.05-0.33) and 0.19 (0.02-0.36)], total-to-HDL cholesterol ratio [0.07 (0.04-0.10) and 0.05 (0.02-0.09)], and body mass index [0.14 (0.12-0.17) and 0.07 (0.04-0.10)]. Conclusion We estimated age- and sex-specific percentiles of CCIMT in a healthy population and assessed the association of CV-RFs with CCIMT Z-scores, which enables comparison of IMT values for (patient) groups with different cardiovascular risk profiles, helping interpretation of such measures obtained both in research and clinical settings.