LUIZ APARECIDO BORTOLOTTO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
16 resultados
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bookPart Abordagem do paciente hipertenso na emergência(2015) BORGES, Fernanda Fatureto; BRITO, Thiago Midlej; DRAGER, Luciano F.; BORTOLOTTO, Luiz AparecidoconferenceObject Potential Underdiagnosis Of Obstructive Sleep Apnea In A Tertiary Cardiology University Hospital(2015) UCHOA, C. H. G.; COSTA, L. E.; HARMON, R. R.; BORTOLOTTO, L. A.; LORENZI-FILHO, G.; DRAGER, L. F.- Coronary events in obese hemodialysis patients before and after renal transplantation(2015) LIMA, Jose Jayme G. De; GOWDAK, Luis Henrique W.; PAULA, Flavio J. de; MUELA, Henrique Cotchi S.; DAVID-NETO, Elias; BORTOLOTTO, Luiz A.We examined the impact of obesity (BMI 30 kg/m(2), n = 357) on prognosis in 1696 hemodialysis (HD) patients before and after renal transplantation (TX). End-points were coronary events, composite cardiovascular (CV) events, and death. Obese HD patients were older (55.9 +/- 9.2 vs. 54.2 +/- 11), had more diabetes (54% vs. 40%), dyslipidemia (49% vs. 30%), altered myocardial scan (38% vs. 31%), myocardial infarction (MI) (16% vs. 10%), coronary intervention (11% vs. 7%), higher total cholesterol (186 +/- 52 vs. 169 +/- 47), and triglycerides (219 +/- 167 vs. 144 +/- 91). Obese undergoing TX had more dyslipidemia (46% vs. 31%), angina (23% vs. 14%), MI (18% vs. 5%), increased total cholesterol (185 +/- 56 vs. 172 +/- 48), and triglycerides (237 +/- 190 vs. 149 +/- 100). Obesity was independently associated with coronary events (log-rank = 0.008, HR 2.55% CI 1.27-5.11) and death (log-rank 0.046, HR 1.52, % CI 1.007-2.30) in TX but not in HD. Obese HD patients had more risk factors and ischemic heart disease, but these characteristics did not interfere with prognosis. In TX patients, obesity predicts coronary events and death.
bookPart Alterações cardíacas associadas ao envelhecimento(2015) SERRO-AZUL, João Batista de; DRAGER, Luciano Ferreira; BORTOLOTTO, Luiz Aparecido; NUSSBACHER, Amit- INTERMITTENT CLAUDICATION IS COMMON AND INDEPENDENTLY ASSOCIATED WITH RENAL ARTERY STENOSIS IN HYPERTENSIVE PATIENTS REFERRED FOR RENAL ARTERIOGRAPHY(2015) BORTOLOTTO, L.; MACEDO, T. A.; PEDROSA, R.; GIORGI, D. M. A.; BRITO, T. M.; DRAGER, L. F.
- Glycemic control and arterial stiffness in a Brazilian rural population: Baependi Heart Study(2015) ALVIM, Rafael de Oliveira; MOURAO-JUNIOR, Carlos Alberto; OLIVEIRA, Camila Maciel de; LIMA, Rerisson de Faria; HORIMOTO, Andrea Roseli Vancan Russo; HONG, Valeria Aparecida Costa; BORTOLOTTO, Luiz Aparecido; KRIEGER, Jose Eduardo; PEREIRA, Alexandre CostaBackground: Increased arterial stiffness predicts morbidity and mortality, independently of other cardiovascular risk factors, and glycemic control impairments are related to higher vascular stiffness. The aim of this study was to evaluate the association between HbA1c levels and increased arterial stiffness in a Brazilian rural population. Methods: For this study were selected 1675 individuals (both genders and aged over 18 years) resident in the municipality of Baependi, a city located in the Southeast of Brazil. HbA1c levels were determined by HPLC. Pulse wave velocity (PWV) was measured with a non-invasive automatic device (Complior). Results: HbA1c levels were associated with an increased PWV. This was more relevant for the third tertile of age. In addition, logistic regression multivariate model including age, blood pressure, gender, BMI and fasting glucose showed that the elevation of a single unit percentage of HbA1c represented an increase of 54 % in the odds of increased arterial stiffness [OR 1.54 (95 % CI 1.01-2.17)]. Both, HbA1c and fasting glucose showed higher discriminatory power in the risk assessment for increased arterial stiffness in the non-diabetic when compared to the diabetic group (AUC of HbA1c = 0.71 vs 0.57, p = 0.02; AUC of fasting glucose = 0.66 vs 0.45, p = 0.0007, respectively). Conclusion: Our findings indicate that a increase in HbA1c levels is associated with increased arterial stiffness and that both, HbA1c and fasting glucose, presented higher discriminatory power in the risk assessment for increased arterial stiffness in the non-diabetic group as compared to diabetic individuals.
conferenceObject Insulin Resistance Impairs Arterial Stiffness and Peripheral Vascular Resistance in Metabolic Syndrome Patients(2015) RODRIGUES, Sara; CEPEDA, Felipe; DUTRA-MARQUES, Akothirene; CARVALHO, Jefferson; TOSCHI-DIAS, Edgar; MAKI-NUNES, Cristiane; BORTOLOTTO, Luiz; COSTA-HONG, Valeria; RONDON, Maria; ALVES, Maria; NEGRAO, Carlos; TOMBETTA, Ivani- Potential underdiagnosis of obstructive sleep apnoea in the cardiology outpatient setting(2015) COSTA, Lucas E.; UCHOA, Carlos Henrique G.; HARMON, Rebeca R.; BORTOLOTTO, Luiz A.; LORENZI-FILHO, Geraldo; DRAGER, Luciano F.Introduction Consistent evidence suggests that obstructive sleep apnoea (OSA) is associated with increased cardiovascular risk. However, it is unclear whether OSA is underdiagnosed in the cardiology outpatient setting. In the present study, we prospectively evaluated the potential underdiagnosis of OSA in several subspecialties from a tertiary cardiology university hospital. Methods Consecutive outpatients from five subspecialties (hypertension, coronary, arrhythmia, heart failure (HF), valvular heart disease) were studied. We performed anthropometric measurements, assessed the risk of OSA using the Berlin Questionnaire and evaluated the prior diagnosis and treatment for OSA. In a subset of patients randomly selected, we performed portable sleep monitoring to objectively evaluate the presence of OSA (defined by an apnoea-hypopnoea index = 15 events/h of sleep). Results We evaluated 500 patients (100 from each subspecialty). The mean age and body mass index (BMI) were 59 +/- 13 years and 28.2 +/- 5.3 kg/m(2), respectively. We found that 51.6% (258 patients) had a high risk for OSA (Berlin Questionnaire). However, only 13 (3.1%) of these patients had a previous diagnosis of OSA. Of those, only six patients were receiving specific OSA treatment. Fifty patients (10 from each specialty) participated in sleep studies. No differences were found in patients who underwent sleep monitoring and those who did not. We found a high frequency of OSA (66%), varying from 50% (hypertension group) to 80% (HF group). Conclusions Despite significant scientific evidence pointing to OSA as an emerging cardiovascular risk factor, OSA is still underdiagnosed in several cardiology subspecialties.
conferenceObject LARGE ARTERIES IMPAIRMENT ARE CORRELATED TO AGEING AND DIABETES IN PATIENTS WITH STAGE 3 HYPERTENSION(2015) BORTOLOTTO, L.; SOUZA, M. G.; HONG, V. C.; GIORGI, D. M. A.; LOPES, H. F.; DRAGER, L. F.; CONSOLIM-COLOMBO, F. M.; KRIEGER, E. M.conferenceObject Hypertension Severity is Associated With Impaired Cognitive Performance(2015) MUELA, Henrique C.; COSTA-HONG, Valeria A.; MACHADO, Michel F.; MORAES, Natalia C.; MEMORIA, Claudia M.; YASSUDA, Monica S.; SHU, Edson B.; NOGUEIRA, Ricardo C.; MASSARO, Ayrton R.; FEITOSA, Raul R.; MERLIN, Silvia; TRES, Eduardo S.; NITRINI, Ricardo; MANSUR, Alfredo J.; BORTOLOTTO, Luiz A.