BRENO JOSE ALENCAR PIRES BARBOSA
Projetos de Pesquisa
Unidades Organizacionais
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina
4 resultados
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- Current clinical and research practices on frontotemporal dementia in Brazil: a national survey(2023) SOUZA, Leonardo Cruz de; BRUCKI, Sonia Maria Dozzi; SCHILLING, Lucas Porcello; SILVA, Leticia Costa da; TAKADA, Leonel Tadao; BAHIA, Valeria Santoro; BARBOSA, Breno Jose Alencar Pires; BALTHAZAR, Marcio Luiz Figueredo; FROTA, Norberto Anizio Ferreira; NITRINI, Ricardo; CARAMELLI, Paulo; SMID, JerusaBackground Frontotemporal dementia (FTD) is a frequent cause of young-onset dementia and represents a major challenge for the diagnosis and clinical management. It is essential to evaluate the difficulties faced by physicians on the diagnostic workup and on patient care.Objective The aim of this study was to investigate the current practices and the local limits on the diagnosis and management of FTD in Brazil.Methods We elaborated an online survey, composed of 29 questions and divided in four parts, comprising questions about existing health facilities, clinical practices related to FTD, and suggestions to increment the national research on FTD. The invitation to participate was sent by email to all neurologists affiliated to the Brazilian Academy of Neurology ( n = 3658), and to all physicians who attended the XII Meeting of Researchers on Alzheimer's disease, in 2019 ( n = 187). The invitation was also diffused through social media.Results 256 Brazilian physicians answered the questionnaire. The three most relevant disorders for the differential diagnosis of FTD were Alzheimer's disease (AD) ( n = 211), bipolar disorder ( n = 117) and dementia with Lewy bodies ( n = 92). Most respondents (125/256) reported the difficulty in performing genetic testing as the main limit in the diagnostic of FTD. 93% and 63% of participants considered that the assessment of social cognition and AD CSF biomarkers are useful for the diagnosis of FTD, respectively.Conclusions The present study may provide valuable insights for the medical education and clinical training of physicians, and to foster future research on FTD in Brazil.
- Current perspectives in stem cell therapy for spinal cord repair in humans: a review of work from the past 10 years(2014) MARIANO, Eric Domingos; BATISTA, Chary Marquez; BARBOSA, Breno Jose Alencar Pires; MARIE, Suely Kazue Nagahashi; TEIXEIRA, Manoel Jacobsen; MORGALLA, Matthias; TATAGIBA, Marcos; LI, Jun; LEPSKI, GuilhermeSpinal cord injury (SCI) and amyotrophic laterals sclerosis (ALS) are devastating neurological conditions that affect individuals worldwide, significantly reducing quality of life, both for patients and their relatives. Objective: The present review aims to summarize the multiple restorative approaches being developed for spinal cord repair, the use of different stem cell types and the current knowledge regarding stem cell therapy. Method: Review of the literature from the past 10 years of human studies using stem cell transplantation as the main therapy, with or without adjuvant therapies. Conclusion: The current review offers an overview of the state of the art regarding spinal cord restoration, and serves as a starting point for future studies.
- Physical exercise as a non-pharmacological strategy for reducing behavioral and psychological symptoms in elderly with mild cognitive impairment and dementia: a systematic review of randomized clinical trials(2021) RODRIGUES, Susana Ligia da Silva; SILVA, Jamily Matias da; OLIVEIRA, Maria Clara Cordeiro de; SANTANA, Charleny Mary Ferreira de; CARVALHO, Kaliandra Meneses; BARBOSA, Breno Jose Alencar PiresBackground: Elderly people with dementia may exhibit behavioral and psychological symptoms throughout the course of disease. Nonpharmacological therapies, such as regular physical activity, are considered strategies for managing these symptoms. Objective: The aim of this study was to investigate whether participation in physical exercise programs is effective in reducing behavioral and neuropsychiatric symptoms in elderly people with Mild Cognitive Impairment (MCI) and dementia. Methods: A literature review was carried out in MEDLINE (PubMed), SciELO, Web of Science, Scopus and SPORTDiscus databases from 2010 to 2020. The eligible studies were randomized clinical trials involving elderly people with mild cognitive impairment or dementia and assessing changes in neuropsychiatric and psychological symptoms as primary or secondary outcomes. The studies had a group with only physical exercise as an intervention compared to a control group. Results: Of 175 publications identified in the initial survey, only 7 studies met the eligibility criteria. Four out of 7 studies demonstrated positive effects in reducing behavioral symptoms, while the others did not report differences between gains according to the type of protocol. Conclusions: Moderate to intense aerobic and muscle strengthening exercises may have a potential benefit in the management of behavioral and psychological symptoms in dementia, but studies varied in their conclusions. This review indicates the need for further intervention studies to investigate, as a primary outcome, the absolute effect of physical exercise and its impact on behavioral and psychological symptoms in elderly people with MCI dementia, especially in the early stages of the disease.
- Posterior cortical ribboning in the Heidenhain variant of Creutzfeldt-Jakob Disease(2020) FREITAS, Camila Silva; PINHEIRO, Marilia Goncalves Maciel; FONTE, Eduardo Jorge da; HAZIN, Adriano Nassri; SMID, Jerusa; BARBOSA, Breno Jose Alencar Pires