THAIS FERNANDA DE ALMEIDA GALATRO
Projetos de Pesquisa
Unidades Organizacionais
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair(2019) MA, Jianhui; BENITE, Jorge A.; LI, Jie; MIKI, Shunichiro; ALBUQUERQU, Claudio Ponte de; GALATRO, Thais; ORELLANA, Laura; ZANCA, Ciro; REED, Rachel; BOYER, Antonia; KOGA, Tomoyuki; VARKI, Nissi M.; FENTON, Tim R.; MARIE, Suely Kazue Nagahashi; LINDAHL, Erik; GAHMAN, Timothy C.; SHIAU, Andrew K.; ZHOU, Huilin; DEGROOT, John; SULMAN, Erik P.; CAVENEE, Webster K.; KOLODNER, Richard D.; CHEN, Clark C.; FURNARI, Frank B.Ionizing radiation (IR) and chemotherapy are standard-of-care treatments for glioblastoma (GBM) patients and both result in DNA damage, however, the clinical efficacy is limited due to therapeutic resistance. We identified a mechanism of such resistance mediated by phosphorylation of PTEN on tyrosine 240 (pY240-PTEN) by FGFR2. pY240-PTEN is rapidly elevated and bound to chromatin through interaction with Ki-67 in response to IR treatment and facilitates the recruitment of RAD51 to promote DNA repair. Blocking Y240 phosphorylation confers radiation sensitivity to tumors and extends survival in GBM preclinical models. Y240F-Pten knockin mice showed radiation sensitivity. These results suggest that FGFR-mediated pY240-PTEN is a key mechanism of radiation resistance and is an actionable target for improving radiotherapy efficacy.
- Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair (vol 35, pg 504, 2019)(2019) MA, Jianhui; BENITEZ, Jorge A.; LI, Jie; MIKI, Shunichiro; ALBUQUERQUE, Claudio Ponte de; GALATRO, Thais; ORELLANA, Laura; ZANCA, Ciro; REED, Rachel; BOYER, Antonia; KOGA, Tomoyuki; VARKI, Nissi M.; FENTON, Tim R.; MARIE, Suely Kazue Nagahashi; LINDAHL, Erik; GAHMAN, Timothy C.; SHIAU, Andrew K.; ZHOU, Huilin; DEGROOT, John; SULMAN, Erik P.; CAVENEE, Webster K.; KOLODNER, Richard D.; CHEN, Clark C.; FURNARI, Frank B.
- Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair (vol 35, pg 504, 2019)(2019) MA, Jianhui; BENITEZ, Jorge A.; LI, Jie; MIKI, Shunichiro; ALBUQUERQUE, Claudio Ponte de; GALATRO, Thais; ORELLANA, Laura; ZANCA, Ciro; REED, Rachel; BOYER, Antonia; KOGA, Tomoyuki; VARKI, Nissi M.; FENTON, Tim R.; MARIE, Suely Kazue Nagahashi; LINDAHL, Erik; GAHMAN, Timothy C.; SHIAU, Andrew K.; ZHOU, Huilin; DEGROOT, John; SULMAN, Erik P.; CAVENEE, Webster K.; KOLODNER, Richard D.; CHEN, Clark C.; FURNARI, Frank B.