GIOVANA SANTOS CALEIRO
Projetos de Pesquisa
Unidades Organizacionais
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
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- Expression of human endogenous retrovirus K and W in babies(2017) NALI, L. H. S.; OLIVEIRA, A. C. S.; ALVES, D. O.; CALEIRO, G. S.; NUNES, C. F.; GERHARDT, D.; SUCCI, R. C. M.; ROMANO, Camila M.; MACHADO, D. M.Here we determined the relative expression of HERV-K and W proviruses in HIV infected and non-infected mothers as well as their respective babies up to 1 year-old. HIV-infected mothers, their babies and uninfected control groups presented expression of both HERV-K and HERV-W with relatively high frequency. While the level of HERV-K expression was similar among groups, the level of HERV-W expression in HIV-infected mothers was four-fold higher than the uninfected mothers from the control group (p < 0.01). HERV-W was down regulated in HIV-exposed babies in comparison to non-exposed babies. To our knowledge, this is the first report of HERV transcriptional activity in babies from 0-1 year-old.