CLARICE GORENSTEIN
Projetos de Pesquisa
Unidades Organizacionais
BMF, ICB - Docente
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina - Líder
4 resultados
Resultados de Busca
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conferenceObject Increased Insula Activity Is Associated with Improved Mood in Healthy Subjects on Clomipramine(2015) BUSATTO, Geraldo; PHILLIPS, Mary L.; CERQUEIRA, Carlos T.; ZILBERMAN, Monica; LOBO, Daniela; HENNA, Elaine; TAVARES, Hermano; AMARO, Edson; LEITE, Claudia C.; GORENSTEIN, Clarice; GENTIL, Valentim; ALMEIDA, Jorge R. C.- Mapping brain volumetric abnormalities in never-treated pathological gamblers(2015) FUENTES, Daniel; RZEZAK, Patricia; PEREIRA, Fabricio R.; MALLOY-DINIZ, Leandro F.; SANTOS, Luciana C.; DURAN, Fabio L. S.; BARREIROS, Maria A.; CASTRO, Claudio C.; BUSATTO, Geraldo F.; TAVARES, Hermano; GORENSTEIN, ClariceSeveral magnetic resonance imaging (MRI) studies to date have investigated brain abnormalities in association with the diagnosis of pathological gambling (PG), but very few of these have specifically searched for brain volume differences between PG patients and healthy volunteers (HV). To investigate brain volume differences between PG patients and HV, 30 male never treated PG patients (DSM-IV-TR criteria) and 30 closely matched HV without history of psychiatric disorders in the past 2 years underwent structural magnetic resonance imaging with a 1.5-T instrument. Using Freesurfer software, we performed an exploratory whole brain voxelwise volume comparison between the PG group and the HV group, with false discovery rate correction for multiple comparisons (p <0.05), Using a more flexible statistical threshold (p < 0.01, uncorrected for multiple comparisons), we also measured absolute and regional volumes of several brain structures separately. The voxelwise analysis showed no clusters of significant regional differences between the PG and HV groups. The additional analyses of absolute and regional brain volumes showed increased absolute global gray matter volumes in PG patients relative to the HV group, as well as relatively decreased volumes specifically in the left putamen, right thalamus and right hippocampus (corrected for total gray matter). Our findings indicate that structural brain abnormalities may contribute to the functional changes associated with the symptoms of PG, and they highlight the relevance of the brain reward system to the pathophysiology of this disorder.
- Learning and memory and its relationship with the lateralization of epileptic focus in subjects with temporal lobe epilepsy(2014) FUENTES, Daniel; MALLOY-DINIZ, Leandro Fernandes; GORENSTEIN, Clarice; CHRISTE, Blaise; BUSATTO, Geraldo F.Background : In medial temporal lobe epilepsy (MTLE), previous studies addressing the hemispheric laterality of epileptogenic focus and its relationship with learning and memory processes have reported controversial findings. Objective : To compare the performance of MTLE patients according to the location of the epileptogenic focus on the left (MTLEL) or right temporal lobe (MTLER) on tasks of episodic learning and memory for verbal and visual content. Methods : One hundred patients with MTLEL and one hundred patients with MTLER were tested with the following tasks: the Rey Auditory Verbal Learning Test (RAVLT) and the Logical Memory-WMS-R to evaluate verbal learning and memory; and the Rey Visual Design Learning Test (RVDLT) and the Visual Reproduction-WMS-R to evaluate visual learning and memory. Results : The MTLEL sample showed significantly worse performance on the RAVLT (p < 0.005) and on the Logical Memory tests (p < 0.01) than MTLER subjects. However, there were no significant between-group differences in regard to the visual memory tests. Discussion : Our findings suggest that verbal learning and memory abilities are dependent on the structural and functional integrity of the left temporal lobe, while visual abilities are less dependent on the right temporal lobe.
- Healthy individuals treated with clomipramine: an fMRI study of brain activity during autobiographical recall of emotions(2014) CERQUEIRA, C. T.; SATO, J. R.; ALMEIDA, J. R. C. de; AMARO JR., E.; LEITE, C. C.; GORENSTEIN, C.; GENTIL, V.; BUSATTO, G. F.Various functional magnetic resonance imaging studies addressed the effects of antidepressant drugs on brain functioning in healthy subjects; however, none specifically investigated positive mood changes to antidepressant drug. Sixteen subjects with no personal or family history of psychiatric disorders were selected from an ongoing 4-week open trial of small doses of clomipramine. Follow-up interviews documented clear positive treatment effects in six subjects, with reduced irritability and tension in social interactions, improved decision making, higher self-confidence and brighter mood. These subjects were then included in a placebo-controlled confirmatory trial and were scanned immediately after 4 weeks of clomipramine use and again 4 weeks after the last dose of clomipramine. The functional magnetic resonance imaging (fMRI) scans were run during emotion-eliciting stimuli. Repeated-measures analysis of variance of brain activity patterns showed significant interactions between group and treatment status during induced irritability (P < 0.005 cluster-based) but not during happiness. Individuals displaying a positive subjective response do clomipramine had higher frontoparietal cortex activity during irritability than during happiness and neutral emotion, and higher temporo-parieto-occipital cortex activity during irritability than during happiness. We conclude that antidepressants not only induce positive mood responses but also act upon autobiographical recall of negative emotions.