BENY LAFER
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Psiquiatria, Faculdade de Medicina - Docente
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Líder
19 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 19
conferenceObject Impact of comorbid anxiety disorders in prospective suicide attempts(2015) ABREU, L. N.; LAFER, B.; BURKE, A.; GRUNEBAUM, M. F.; SHER, L.; SULLIVAN, G. M.; SUBLETTE, M. E.; PIETROBON, R.; VISSOCI, J. R.; MANN, J. J.; OQUENDO, M. A.conferenceObject A comparison of caregivers of patients with bipolar disorder and Alzheimer's disease: similar levels of burden and greater distress in bipolar disorder(2015) SANTOS, G. D.; LADEIRA, R. B.; ALMEIDA, J. G.; APRAHAMIAN, I.; FORLENZA, O. V.; LAFER, B.; NUNES, P.- Influence of birth cohort on age of onset cluster analysis in bipolar I disorder(2015) BAUER, M.; GLENN, T.; ALDA, M.; ANDREASSEN, O. A.; ANGELOPOULOS, E.; ARDAU, R.; BAETHGE, C.; BAUER, R.; BELLIVIER, F.; BELMAKER, R. H.; BERK, M.; BJELLA, T. D.; BOSSINI, L.; BERSUDSKY, Y.; CHEUNG, E. Y. W.; CONELL, J.; ZOMPO, M. Del; DODD, S.; ETAIN, B.; FAGIOLINI, A.; FRYE, M. A.; FOUNTOULAKIS, K. N.; GARNEAU-FOURNIER, J.; GONZALEZ-PINTO, A.; HARIMA, H.; HASSEL, S.; HENRY, C.; IACOVIDES, A.; ISOMETSA, E. T.; KAPCZINSKI, F.; KLIWICKI, S.; KOENIG, B.; KROGH, R.; KUNZ, M.; LAFER, B.; LARSEN, E. R.; LEWITZKA, U.; LOPEZ-JARAMILLO, C.; MACQUEEN, G.; MANCHIA, M.; MARSH, W.; MARTINEZ-CENGOTITABENGOA, M.; MELLE, I.; MONTEITH, S.; MORKEN, G.; MUNOZ, R.; NERY, F. G.; O'DONOVAN, C.; OSHER, Y.; PFENNIG, A.; QUIROZ, D.; RAMESAR, R.; RASGON, N.; REIF, A.; RITTER, P.; RYBAKOWSKI, J. K.; SAGDUYU, K.; SCIPPA, A. M.; SEVERUS, E.; SIMHANDL, C.; STEIN, D. J.; STREJILEVICH, S.; SULAIMAN, A. Hatim; SUOMINEN, K.; TAGATA, H.; TATEBAYASHI, Y.; TORRENT, C.; VIETA, E.; VISWANATH, B.; WANCHOO, M. J.; ZETIN, M.; WHYBROW, P. C.Purpose: Two common approaches to identify subgroups of patients with bipolar disorder are clustering methodology (mixture analysis) based on the age of onset, and a birth cohort analysis. This study investigates if a birth cohort effect will influence the results of clustering on the age of onset, using a large, international database. Methods: The database includes 4037 patients with a diagnosis of bipolar I disorder, previously collected at 36 collection sites in 23 countries. Generalized estimating equations (GEE) were used to adjust the data for country median age, and in some models, birth cohort. Model-based clustering (mixture analysis) was then performed on the age of onset data using the residuals. Clinical variables in subgroups were compared. Results: There was a strong birth cohort effect. Without adjusting for the birth cohort, three subgroups were found by clustering. After adjusting for the birth cohort or when considering only those born after 1959, two subgroups were found. With results of either two or three subgroups, the youngest subgroup was more likely to have a family history of mood disorders and a first episode with depressed polarity. However, without adjusting for birth cohort (three subgroups), family history and polarity of the first episode could not be distinguished between the middle and oldest subgroups. Conclusion: These results using international data confirm prior findings using single country data, that there are subgroups of bipolar I disorder based on the age of onset, and that there is a birth cohort effect. Including the birth cohort adjustment altered the number and characteristics of subgroups detected when clustering by age of onset. Further investigation is needed to determine if combining both approaches will identify subgroups that are more useful for research.
conferenceObject Factors associated with greater burden of caregivers of elderly bipolar patients: the importance of functionality and neuropsychiatric symptoms(2015) SANTOS, G. D.; ALMEIDA, J. G.; APRAHAMIAN, I.; FORLENZA, O. V.; LAFER, B.; NUNES, P.conferenceObject Implications and impressions of the ISBD Task Force DSM5 on mixed depression in bipolar disorder(2015) FRYE, M. A.; SWANN, A. C.; LAFER, B.; PERUGI, G.; BAUER, M.; BAHK, W. M.; SCOTT, J.; HA, K.; SUPPES, T.- Influence of light exposure during early life on the age of onset of bipolar disorder(2015) BAUER, Michael; GLENN, Tasha; ALDA, Martin; ANDREASSEN, Ole A.; ANGELOPOULOS, Elias; ARDAU, Raffaella; BAETHGE, Christopher; BAUER, Rita; BAUNE, Bernhard T.; BELLIVIER, Frank; BELMAKER, Robert H.; BERK, Michael; BJELLA, Thomas D.; BOSSINI, Letizia; BERSUDSKY, Yuly; CHEUNG, Eric Yat Wo; CONELL, Joern; ZOMPO, Maria Del; DODD, Seetal; ETAIN, Bruno; FAGIOLINI, Andrea; FRYE, Mark A.; FOUNTOULAKIS, Kostas N.; GARNEAU-FOURNIER, Jade; GONZALEZ-PINTO, Ana; GOTTLIEB, John F.; HARIMA, Hirohiko; HASSEL, Stefanie; HENRY, Chantal; IACOVIDES, Apostolos; ISOMETSA, Erkki T.; KAPCZINSKI, Flavio; KLIWICKI, Sebastian; KOENIG, Barbara; KROGH, Rikke; KUNZ, Mauricio; LAFER, Beny; LARSEN, Erik R.; LEWITZKA, Ute; LOPEZ-JARAMILLO, Carlos; MACQUEEN, Glenda; MANCHIA, Mirko; MARSH, Wendy; MARTINEZ-CENGOTITABENGO, Monica; MELLE, Ingrid; MONTEITH, Scott; MORKEN, Gunnar; MUNOZ, Rodrigo; NERY, Fabiano G.; O'DONOVAN, Claire; OSHER, Yamima; PFENNIG, Andrea; QUIROZ, Danilo; RAMESAR, Raj; RASGON, Natalie; REIF, Andreas; RITTER, Philipp; RYBAKOWSKI, Janusz K.; SAGDUYU, Kemal; MIRANDA-SCIPPA, Angela; SEVERUS, Emanuel; SIMHANDL, Christian; STEIN, Dan J.; STREJILEVICH, Sergio; SULAIMAN, Ahmad Hatim; SUOMINEN, Kirsi; TAGATA, Hiromi; TATEBAYASHI, Yoshitaka; TORRENT, Carla; VIETA, Eduard; VISWANATH, Biju; WANCHOO, Mihir J.; ZETIN, Mark; WHYBROW, Peter C.Background: Environmental conditions early in life may imprint the circadian system and influence response to environmental signals later in life. We previously determined that a large springtime increase in solar insolation at the onset location was associated with a younger age of onset of bipolar disorder, especially with a family history of mood disorders. This study investigated whether the hours of daylight at the birth location affected this association. Methods: Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4 N and 70.7 N, and 1.2 S and 413 S. Hours of daylight variables for the birth location were added to a base model to assess. the relation between the age of onset and solar insolation. Results: More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model. Conclusions: Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life.
- Gray matter volumes in patients with bipolar disorder and their first-degree relatives(2015) NERY, Fabiano G.; GIGANTE, Alexandre Duarte; AMARAL, Jose A.; FERNANDES, Francy B. F.; BERUTTI, Mariangeles; ALMEIDA, Karla M.; CARNEIROC, Camila de Godoi; DURAN, Fabio Luis Souza; OTADUY, Maria G.; LEITE, Claudia Costa; BUSATTO, Geraldo; LAFER, BenyBipolar disorder (BD) is highly heritable. First-degree relatives of BD patient have an increased risk to develop the disease. We investigated abnormalities in gray matter (GM) volumes in healthy first-degree relatives of BD patients to identify possible brain structural endophenotypes for the disorder. 3D T1-weighted magnetic resonance images were obtained from 25 DSM-IV BD type I patients, 23 unaffected relatives, and 27 healthy controls (HC). A voxel-based morphometry protocol was used to compare differences in GM volumes between groups. BD patients presented reduced GM volumes bilaterally in the thalamus compared with HC. Relatives presented no global or regional GM differences compared with HC. Our negative results do not support the role of GM volume abnormalities as endophenotypes for BD. Thalamic volume abnormalities may be associated the pathophysiology of the disease.
- The Bipolar Depression Electrical Treatment Trial (BETTER): Design, Rationale, and Objectives of a Randomized, Sham-Controlled Trial and Data from the Pilot Study Phase(2015) PEREIRA JUNIOR, Bernardo de Sampaio; TORTELLA, Gabriel; LAFER, Beny; NUNES, Paula; BENSENOR, Isabela Martins; LOTUFO, Paulo Andrade; MACHADO-VIEIRA, Rodrigo; BRUNONI, Andre R.Background. Bipolar depression (BD) is a prevalent condition, with poor therapeutic options and a high degree of refractoriness. This justifies the development of novel treatment strategies, such as transcranial direct current stimulation (tDCS) that showed promising results in unipolar depression. Methods. We describe a randomized, sham-controlled, double-blinded trial using tDCS for refractory, acutely symptomatic BD (the bipolar depression electrical treatment trial, BETTER). Sixty patients will be enrolled and assessed with clinical and neuropsychological tests. The primary outcome is change (over time and across groups) in the scores of the Hamilton Depression Rating Scale (17 items). Biological markers such as blood neurotrophins and interleukins, genetic polymorphisms, heart rate variability, and motor cortical excitability will be assessed. Twelve anodal-left/cathodal-right 2 mA tDCS sessions over the dorsolateral prefrontal cortex will be performed in 6 weeks. Results. In the pilot phase, five patients received active tDCS and were double-blindly assessed, two presenting clinical response. TDCS was well-tolerated, with no changes in cognitive scores. Conclusion. This upcoming clinical trial will address the efficacy of tDCS for BD on different degrees of refractoriness. The evaluation of biological markers will also help in understanding the pathophysiology of BD and the mechanisms of action of tDCS.
conferenceObject THE RELATIONSHIP BETWEEN SOCIAL SKILLS AND EPISODIC MEMORY IN PATIENTS WITH SCHIZOPHRENIA(2015) OLIVEIRA, Graca M. R.; ROCCA, Cristiana C. A.; SCEMES, Silvia; LAFER, Beny; ELKIS, Helio- Attention-based classification pattern, a research domain criteria framework, in youths with bipolar disorder and attention-deficit/hyperactivity disorder(2015) KLEINMAN, Ana; CAETANO, Sheila Cavalcante; BRENTANI, Helena; ROCCA, Cristiana Castanho de Almeida; SANTOS, Bernardo dos; ANDRADE, Enio Roberto; ZENI, Cristian Patrick; TRAMONTINA, Silza; ROHDE, Luis Augusto Paim; LAFER, BenyObjective: The National Institute of Mental Health has initiated the Research Domain Criteria (RDoC) project. Instead of using disorder categories as the basis for grouping individuals, the RDoC suggests finding relevant dimensions that can cut across traditional disorders. Our aim was to use the RDoC's framework to study patterns of attention deficit based on results of Conners' Continuous Performance Test (CPT II) in youths diagnosed with bipolar disorder (BD), attention-deficit/hyperactivity disorder (ADHD), BD+ADHD and controls. Method: Eighteen healthy controls, 23 patients with ADHD, 10 with BD and 33 BD+ADHD aged 12-17 years old were assessed. Pattern recognition was used to partition subjects into clusters based simultaneously on their performance in all CPT II variables. A Fisher's linear discriminant analysis was used to build a classifier. Results: Using cluster analysis, the entire sample set was best clustered into two new groups, A and B, independently of the original diagnoses. ADHD and BD+ADHD were divided almost 50% in each subgroup, and there was an agglomeration of controls and BD in group B. Group A presented a greater impairment with higher means in all CPT II variables and lower Children's Global Assessment Scale. We found a high cross-validated classification accuracy for groups A and B: 95.2%. Variability of response time was the strongest CPT II measure in the discriminative pattern between groups A and B. Conclusion: Our classificatory exercise supports the concept behind new approaches, such as the RDoC framework, for child and adolescent psychiatry. Our approach was able to define clinical subgroups that could be used in future pathophysiological and treatment studies.